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CAS No 74011-58-8 , 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,8-naphthyridine-3-carboxylic
acid

  • Name: 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,8-naphthyridine-3-carboxylic
    acid
  • Synonyms: Penetrex; Enoxacinum; Enoxacino; 74011-58-8; Flumark; Enoxacine; Bactidan; Enoxor;1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,8-naphthyridine-3-carboxylic
    acid; Comprecin;
  • CAS Registry Number:
  • Melting Point: 220-224 ºC
  • Flash Point: 298.4 ºC
  • Boiling Point: 569.9 ºC at 760 mmHg
  • Density: 1.388 g/cm3
  • Water Solubility: Insoluble
  • Safety Statements: Poison by intravenous route. Moderately toxic by subcutaneous route. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of F− and NOx.
  • Hazard Symbols: Xi: Irritant;
  • Flash Point: 298.4 ºC
  • Molecular Weight: 320.318883
  • InchiKey: IDYZIJYBMGIQMJ-UHFFFAOYSA-N
  • InChI: InChI=1S/C15H17FN4O3/c1-2-19-8-10(15(22)23)12(21)9-7-11(16)14(18-13(9)
    19)20-5-3-17-4-6-20/h7-8,17H,2-6H2,1H3,(H,22,23)
  • Risk Statements: R36/37/38
  • Molecular Formula: C15H17FN4O3
  • Molecular Structure:CAS No:74011-58-8 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,8-naphthyridine-3-carboxylic<br />acid

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References of 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,8-naphthyridine-3-carboxylic
acid
Title: Enoxacin
CAS Registry Number: 74011-58-8
CAS Name: 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid
Manufacturers' Codes: AT-2266; CI-919; PD-107779
Trademarks: Comprecin (Parke-Davis); Flumark (Dainippon)
Molecular Formula: C15H17FN4O3
Molecular Weight: 320.32
Percent Composition: C 56.24%, H 5.35%, F 5.93%, N 17.49%, O 14.98%
Literature References: Fluorinated quinolone antibacterial; nalidixic acid analog. Prepn and antibacterial activity: J. Matsumoto et al., EP 9425; eidem, US 4352803; eidem, US 4359578 (1980, 1982, 1982 all to Dainippon and Roger Bellon); J. Matsumoto et al., J. Med. Chem. 27, 292 (1984). HPLC determn in plasma, urine: T. B. Vree et al., J. Chromatogr. 343, 449 (1985). In vitro comparison with other quinolones and azaquinolones: S. Selwyn, M. Bakhtiar, Drugs Exp. Clin. Res. 10, 653 (1984). Pharmacokinetics, therapeutic efficacy: K. G. Naber et al., Infection 13, 219 (1985). Efficacy in treatment of urinary tract infections: R. R. Bailey, B. A. Peddie, N. Z. Med. J. 98, 286 (1985). Toxicology studies: H. Senda et al., Chemotherapy (Tokyo) 32, Suppl. 3, 192 (1984). Series of articles on activity, pharmacology, metabolism, early clinical studies: ibid. 1-1093; J. Antimicrob. Chemother. 14, Suppl. C, 1-96 (1984); on activity, pharmacokinetics, clinical safety and efficacy: Infection 14, Suppl. 3, S183-S220 (1986).
Properties: Crystals from ethanol/methylene chloride, mp 220-224°. LD50 in male, female mice, male, female rats (mg/kg): 327, 391, 236, 294 i.v.; 1237, 1320, >2000, >2000 s.c.; all >5000 orally (Senda).
Melting point: mp 220-224°
Toxicity data: LD50 in male, female mice, male, female rats (mg/kg): 327, 391, 236, 294 i.v.; 1237, 1320, >2000, >2000 s.c.; all >5000 orally (Senda)
 
Derivative Type: Sesquihydrate
CAS Registry Number: 84294-96-2
Trademarks: Bactidan (Fabre); Enoxen (Dainippon); Enoxor (Fabre); Gyramid (Warner-Lambert)
Molecular Formula: C15H17FN4O3.1?H2O
Molecular Weight: 329.33
Percent Composition: C 54.71%, H 5.51%, F 5.77%, N 17.01%, O 17.00%
 
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Synthetic); Quinolones and Analogs.