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CAS No 745-65-3 , Prostaglandin E1

  • Name: Prostaglandin E1
  • Synonyms: PGE1; 3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxo-cyclopentaneheptanoic acid;11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid;ALPROSTADIL;Prostaglandin E1; Prostaglandin E1 or AIPROSTADIL; Alprostadil (prostandin E1);
  • CAS Registry Number:
  • Transport: UN 2811
  • Melting Point: 115-116 ºC
  • Density: 1.131 g/cm3
  • Alpha: -64 º (C=1.0, C2H5OH)
  • Safety Statements: R22
  • Hazard Symbols: Xn: Harmful;
  • EINECS: 212-017-2
  • Molecular Weight: 354.48
  • InChI: InChI=1/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17?,19+/m0/s1
  • Risk Statements: S36
  • Molecular Formula: C20H34O5
  • Molecular Structure:CAS No:745-65-3 Prostaglandin E1
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745-65-3 Alprostadil

  • China Watson International Ltd. null
  • Tel: +86-(512)-55117610
  • Fax: +86-(512)-55117630
  • Address: Room 1209, Asia Pacific Plaza, Huaqiao International Business Park, Kunshan, Jiangsu 215332, null,nullChina
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745-65-3 Alprostadil

  • China China Langchem Inc. null
  • Tel: +86-(21)-58956006
  • Fax: +86-(21)-58956100
  • Address: 514 Room, 1# Building, 88# Cailun Road, Zhangjiang High Tech Park, Shanghai 201203, null,nullChina
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745-65-3 Alprostadil

  • China Haihang Industry Co., Ltd. null
  • Tel: +86-(531)-88032799
  • Fax: +86-(531)-85821093
  • Address: 2/F, East Tower, Bldg 12, No. 2 Qilihe Road, Jinan 250100, null,nullChina
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745-65-3 Alprostadil

  • Alprostadil
  • United Kingdom Molekula Ltd [Manufacturer]
  • Tel: +44 1202 863000
  • Fax: +44 1202 863003
  • Address: Technology House Old Forge Road Ferndown Industrial Estate Wimborne Dorset Bh21 7RR null,nullUnited Kingdom
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745-65-3 Prostaglandin E1

  • China Shanghai chemrole co.,ltd [Manufacturers]
  • Tel: 021-50278900
  • Fax: 021-50278968
  • Address: No.6,bisheng road ,shanghai ,china null,ShanghaiChina
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745-65-3 Prostaglandin E1

  • Hong kong Achemo Sientific cooperation [Manufacturers]
  • Tel: 00852-39711547
  • Fax: 00852-39711547
  • Address: 38 Plaza,38 Shantung street,MongKoK,kowloon,Hongkong Kowloon,KowloonHong kong
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745-65-3 Alprostadil

  • Alprostadil, > 98%
  • Switzerland BIOTREND Chemicals AG [Manufacturer]
  • Tel: +41 44 805 76 76
  • Fax: +41 44 805 76 77
  • Address: BIOTREND Chemicals AG
    Unterdorfstr. 21b
    CH-8602 Wangen/Zuerich
    Switzerland null,nullSwitzerland
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745-65-3 Prostaglandin E1

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745-65-3 Alprostadil

  • China Xilin Chemical Group Co., Ltd null
  • Tel: +86-(0)-15527136576
  • Fax: +86-(27)-83820093
  • Address: 16# Luojiashan, Wuchang District, Wuhan, Hubei 430071, null,nullChina
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745-65-3 Alprostadil

  • China Laiwu Hehui Chemical Co.,Ltd. null
  • Tel: +86-(531)-88772589
  • Fax: +86-(531)-88772589
  • Address: Huashan Rd., Jinan City, Shandong 250000, null,nullChina
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References of Prostaglandin E1
Title: Prostaglandin E1
CAS Registry Number: 745-65-3
CAS Name: (11a,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid
Synonyms: 3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentaneheptanoic acid; alprostadil; PGE1
Manufacturers' Codes: U-10136
Trademarks: Caverject (Pharmacia & Upjohn); Edex (Schwarz); Liple (Mitsubishi); Liprostin (Endovasc); Minprog (Pharmacia); Muse (Meda); Palux (Taisho); Prostandin (Ono); Prostin VR (Pharmacia & Upjohn); Prostivas (Pharmacia & Upjohn)
Molecular Formula: C20H34O5
Molecular Weight: 354.48
Percent Composition: C 67.77%, H 9.67%, O 22.57%
Literature References: A primary prostaglandin; easily crystallized from purified biological extracts. Isoln from sheep seminal vesicle tissue, and structure: Bergstrom et al., Acta Chem. Scand. 16, 501 (1962); eidem, J. Biol. Chem. 238, 3555 (1963). Enzymic conversion from 8,11,14-eicosatrienoic acid: Nugteren et al., Rec. Trav. Chim. 85, 405 (1966). Synthesis of the dl-form: Corey et al., J. Am. Chem. Soc. 90, 3245, 3247 (1968); Schneider et al., ibid. 5895; 91, 5372 (1969); Axen et al., Chem. Commun. 1969, 303; Taub et al., ibid. 1970, 1258; Slates et al., ibid. 1972, 304; Kuo et al., Tetrahedron Lett. 1972, 5317; Taub et al., Tetrahedron 29, 1447 (1973); Miyano, Stealey, Chem. Commun. 1973, 180; Finch et al., J. Org. Chem. 38, 4412 (1973). Synthesis of natural form: Corey et al., J. Am. Chem. Soc. 91, 535 (1969); 92, 2586 (1970); Sih et al., ibid. 94, 3643 (1972); 95, 1676 (1973); Schaaf, Corey, J. Org. Chem. 37, 2921 (1974); Slates et al., Tetrahedron 30, 819 (1974). Metabolism in guinea pigs: Anggard, Samuelsson, J. Biol. Chem. 239, 4097 (1964). Metabolism in humans: Hamberg, Samuelsson, ibid. 246, 6713 (1971). Review of biological activities: Berti et al., Prog. Biochem. Pharmacol. 3, 110 (1967). Comparative pharmacology with respect to other prostaglandins: Weeks, Annu. Rev. Pharmacol. 12, 317 (1972). Clinical use in neonates with cyanotic congenital heart disease: P. M. Olley et al., Adv. Prostaglandin Thromboxane Res. 7, 913 (1980). Use in non-atherosclerotic vasculopathy: D. L. Wooster et al., J. Am. Med. Assoc. 245, 1846 (1981). Clinical trials in impotence: O. I. Linet, F. G. Ogrinc, N. Engl. J. Med. 334, 873 (1996); H. Padma-Nathan et al., ibid. 336, 1 (1997).
Properties: Crystals from ethyl acetate + heptane, mp 115-116°. [a]578 -61.6° (c = 0.56 in tetrahydrofuran). Soly at 35°: 8000 mg/100 ml double distilled water. Easily dehydrated in soln at pHs <4 or >8.
Melting point: mp 115-116°
Optical Rotation: [a]578 -61.6° (c = 0.56 in tetrahydrofuran)
Therap-Cat: Vasodilator (peripheral). In treatment of male erectile dysfunction.
Keywords: Prostaglandin/Prostaglandin Analog; Vasodilator (Peripheral).