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CAS No 76-03-9 , Trichloroacetic acid

  • Name: Trichloroacetic acid
  • Synonyms: Trichloroacetic acid solution; fpia precipitation;TCA;Trichloroacetic acid;
  • CAS Registry Number:
  • Transport: UN 1839/2564
  • Melting Point: 52-58 ºC
  • Flash Point: Not considered to be a fire hazard
  • Boiling Point: 196 ºC
  • Density: 1.6298
  • Refractive index: n20/D 1.62(lit.)
  • Water Solubility: 120 G/100 ML (20 ºC)
  • Safety Statements: R35;R50/53
  • Hazard Symbols: C: Corrosive;N: Dangerous for the environment;
  • HS Code: 29154000
  • Flash Point: Not considered to be a fire hazard
  • EINECS: 200-927-2
  • Molecular Weight: 163.39
  • InChI: InChI=1/C2HCl3O2/c3-2(4,5)1(6)7/h(H,6,7)
  • Risk Statements: S26;S36/37/39;S45;S60;S61
  • Molecular Formula: C2HCl3O2
  • Molecular Structure:CAS No:76-03-9 Trichloroacetic acid
References of Trichloroacetic acid
Title: Trichloroacetic Acid
CAS Registry Number: 76-03-9
Synonyms: TCA
Molecular Formula: C2HCl3O2
Molecular Weight: 163.39
Percent Composition: C 14.70%, H 0.62%, Cl 65.10%, O 19.58%
Line Formula: CCl3COOH
Literature References: Prepd by oxidation of chloral hydrate with nitric acid: Parkes, Hollingshead, Chem. Ind. (London) 1954, 222. Manuf by chlorination of acetic acid: Eaker, US 2832803 (1958 to Monsanto). Toxicity study: G. W. Bailey, J. L. White, Residue Rev. 10, 97 (1965).
Properties: Very deliquesc crystals; slight characteristic odor. d461 1.629; mp 57-58°; bp 196-197°. Sol in 0.1 part water; very sol in alcohol, ether; dec by heating with caustic alkalies into chloroform and alkali carbonate. Its aq soln is very acid. pH of 0.1 molar aq soln 1.2. Keep tightly closed in a cool place. Storage of trichloroacetic acid solns in water of less than 30% strength is not recommended. Decompn products are chloroform, hydrochloric acid, carbon dioxide and carbon monoxide. LD50 orally in rats: 5000 mg/kg (Bailey, White).
Melting point: mp 57-58°
Boiling point: bp 196-197°
Density: d461 1.629
Toxicity data: LD50 orally in rats: 5000 mg/kg (Bailey, White)
 
Derivative Type: Ethyl ester
CAS Registry Number: 515-84-4
Synonyms: Ethyl trichloroacetate
Molecular Formula: C4H5Cl3O2
Molecular Weight: 191.44
Percent Composition: C 25.10%, H 2.63%, Cl 55.56%, O 16.71%
Properties: Clear liq; odor resembling menthol. d420 1.383. bp 168°. nD20 1.4507. Insol in water. Misc with alcohol, ether.
Boiling point: bp 168°
Index of refraction: nD20 1.4507
Density: d420 1.383
 
Derivative Type: Sodium salt
CAS Registry Number: 650-51-1
Synonyms: Sodium trichloroacetate
Trademarks: Konesta (Akzo); Varitox (M & B)
Molecular Formula: C2Cl3NaO2
Molecular Weight: 185.37
Percent Composition: C 12.96%, Cl 57.38%, Na 12.40%, O 17.26%
Properties: Yellow deliquesc powder, mp >300°. Soly in water at 25°: 1.2 kg/l. Sol in ethanol.
Melting point: mp >300°
 
CAUTION: Potential symptoms of overexposure are irritation of eyes, skin, nose, throat, respiratory system; cough, dyspnea, delayed pulmonary edema; eye and skin burns; dermatitis; salivation, vomiting, diarrhea. See NIOSH Pocket Guide to Chemical Hazards (DHHS/NIOSH 97-140, 1997) p 314.
Use: As a decalcifier and fixative in microscopy; also as a precipitant of protein. As herbicide.
Therap-Cat: Caustic.
Therap-Cat-Vet: Caustic, vesicant.