Home > Name List By other > (4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4, 12-methanobenzofuro[3,2-e]isoquinoline-7-ol

CAS No 76-57-3 , (4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,
12-methanobenzofuro[3,2-e]isoquinoline-7-ol

  • Name: (4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,
    12-methanobenzofuro[3,2-e]isoquinoline-7-ol
  • Synonyms: Morphine monomethyl ether; Codicept; Norcodine; Codeine anhydrous; Norcodeine; l-Codeine; N-methyl; Coducept;Methylmorphine;(4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,
    12-methanobenzofuro[3,2-e]isoquinoline-7-ol;
  • CAS Registry Number:
  • Transport: UN 1230 3/PG 2
  • Melting Point: 154 - 156 C
  • Flash Point: 75 C
  • Boiling Point: 462°C at 760 mmHg
  • Density: 1.34g/cm3
  • Refractive index: 1.666
  • Safety Statements: 7-16-36/37-45
  • Hazard Symbols: F,T
  • Flash Point: 75 C
  • EINECS: 200-969-1
  • Molecular Weight: 299.36424
  • InchiKey: OROGSEYTTFOCAN-DNJOTXNNSA-N
  • InChI: InChI=1S/C18H21NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10
    (15(16)18)9-12(11)19/h3-6,11-13,17,20H,7-9H2,1-2H3/t11-,12+,13-,17-,
    18-/m0/s1
  • Risk Statements: 11-23/24/25-39/23/24/25
  • Molecular Formula: C18H21NO3
  • Molecular Structure:CAS No:76-57-3 (4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,<br />12-methanobenzofuro[3,2-e]isoquinoline-7-ol
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76-57-3 CODEINE

  • Hong kong Advanced Technology & Industrial Co., Ltd. [Manufacturer]
  • Tel: (852) 2390 2293/ (852) 2394 5546
  • Fax: (852) 2789 8314
  • Address: Unit B, 1/F., Cheong Shing Bldg.,
    17 Walnut St., Tai Kok Tsui, Kln,
    Hong Kong ,Hong kong
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76-57-3 Codeine

  • Codeine
  • China Shanghai Synnad Chemical Co., Ltd. [Importer/Exporter]
  • Tel: 86 21 5109 7911
  • Fax: 86 21 5109 7955
  • Address: B-5 Ecust Science Park, No. 18, Lane 1305, Hua Jing Road, Shanghai 200231 China Shanghai,ShanghaiChina
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76-57-3 Codeine

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76-57-3 CODEINE (FREE BASE)

  • Norway Chiron AS [Manufacturer]
  • Tel: +47 73 87 44 90
  • Fax: +47 73 87 44 99
  • Address: Chiron AS
    Stiklestadveien 1
    N-7041 Trondheim
    Norway ,Norway
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76-57-3 Codeine base

  • India Manus Aktteva []
  • Tel: +91-(79)-65123395
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  • Address: 303, 3rd Floor, Royale Manor, Law Garden, Dhulia Kot Road, Ellisbridge, Ahmedabad, Gujarat 380006, ,India
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76-57-3 Codeine (free base)

  • Codeine (free base)
  • Norway Chiron AS [Manufacturer]
  • Tel: +47-73 87 44 90
  • Fax: +47-73 87 44 99
  • Address: Stiklestadveien 1N-7041 TrondheimNORWAY Trondheim,Norway
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76-57-3 CODEINE

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76-57-3 1562.18-100MG CODEINE (FREE BASE)

  • Germany Campro Scientific GmbH [Manufacturer]
  • Tel: +49.(0)30.629.01.89.0 (Germany)/ +31.(0)318.529.437 (Netherlands)
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  • Address: Campro Scientific GmbH
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76-57-3 CODEINE)

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
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References of (4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,
12-methanobenzofuro[3,2-e]isoquinoline-7-ol
Title: Codeine
CAS Registry Number: 76-57-3
CAS Name: (5a,6a)-7,8-Didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-ol
Synonyms: methylmorphine; morphine monomethyl ether; morphine 3-methyl ether
Trademarks: Codicept (Sanol)
Molecular Formula: C18H21NO3
Molecular Weight: 299.36
Percent Composition: C 72.22%, H 7.07%, N 4.68%, O 16.03%
Literature References: Present in opium from 0.7 to 2.5%, depending on the source, but mostly prepd by methylation of morphine, q.v. Discussion of structure and bibliography: Small, Lutz, "Chemistry of the Opium Alkaloids," in U.S. Public Health Reports Suppl. No. 103 (Washington, 1932). Prepn of (+)-codeine and racemate: Goto, Yamamoto, Proc. Jpn. Acad. 30, 769 (1954), C.A. 50, 1052h (1956); of (-)-form: E. J. Bijsterveld, H. J. Sinnige, Rec. Trav. Chim. 95, 24 (1976); H. C. Beyerman et al., ibid. 97, 127 (1978). Manuf from morphine: W. R. Heumann, Bull. Narc. X, 15 (1958). Facile synthesis from thebaine, q.v.: W. G. Dauben et al., J. Org. Chem. 44, 1567 (1979). Toxicity of the hydrochloride: Eddy, Sumwalt, J. Pharmacol. Exp. Ther. 67, 127 (1939). Comprehensive description of codeine and codeine phosphate, q.v.: F. J. Muhtadi, M. M. A. Hassan, Anal. Profiles Drug Subs. 10, 93-138 (1981).
 
Derivative Type: Monohydrate
Properties: Orthorhombic sphenoidal rods or tablets (octahedra) from water or dil alcohol, mp 154-156° (after drying at 80°). Sublimes (when anhydr) at 140-145° under 1.5 mm pressure. Melts to oily drops when heated in an amount of water insufficient for complete soln, crystallizes on cooling. d420 1.32. [a]D15 -136° (c = 2 in alcohol), [a]D15 -112° (c = 2 in chloroform). pK (15°) 6.05; pH of satd aq soln 9.8. One gram dissolves in 120 ml water, 60 ml water at 80°, 2 ml alcohol, 1.2 ml hot alcohol, 13 ml benzene, 18 ml ether, 0.5 ml chloroform; freely sol in amyl alcohol, methanol, dil acids. Almost insol in petr ether or in solns of alkali hydroxides.
Melting point: mp 154-156° (after drying at 80°)
pKa: pK (15°) 6.05; pH of satd aq soln 9.8
Optical Rotation: [a]D15 -136° (c = 2 in alcohol); [a]D15 -112° (c = 2 in chloroform)
Density: d420 1.32
 
Derivative Type: Hydrochloride
CAS Registry Number: 1422-07-7
Molecular Formula: C18H21NO3.HCl
Molecular Weight: 335.83
Percent Composition: C 64.38%, H 6.60%, N 4.17%, O 14.29%, Cl 10.56%
Properties: Dihydrate, small needles, mp ~280° with some decompn. [a]D22 -108°. One gram dissolves in 20 ml water, 1 ml boiling water, 180 ml alcohol. pH about 5. LD50 s.c. in mice: 300 mg/kg (Eddy, Sumwalt).
Melting point: mp ~280° with some decompn
Optical Rotation: [a]D22 -108°
Toxicity data: LD50 s.c. in mice: 300 mg/kg (Eddy, Sumwalt)
 
Derivative Type: Sulfate
CAS Registry Number: 1420-53-7
Molecular Formula: (C18H21NO3)2.H2SO4
Molecular Weight: 696.81
Percent Composition: C 62.05%, H 6.36%, N 4.02%, O 22.96%, S 4.60%
Properties: Trihydrate, crystals or cryst powder. One gram dissolves in 30 ml water, 6.5 ml water at 80°, 1300 ml alc. Insol in chloroform or ether. pH: 5.0. Store in airtight containers; protect from light.
 
NOTE: This is a controlled substance (opiate): 21 CFR, 1308.12.
Therap-Cat: Analgesic (narcotic); antitussive.
Therap-Cat-Vet: Analgesic (narcotic); antitussive.
Keywords: Analgesic (Narcotic); Antitussive.