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CAS No 77-20-3 , (1,3-dimethyl-4-phenylpiperidin-4-yl) propanoate

  • Name: (1,3-dimethyl-4-phenylpiperidin-4-yl) propanoate
  • Synonyms: Alphaprodine [INN:BAN]; Betaprodine; ALPHAPRODINE; alpha-Prodinol; Prisilidene;(1,3-dimethyl-4-phenylpiperidin-4-yl) propanoate; beta-Prodine; Prodine;Alphaprodin;
  • CAS Registry Number:
  • Flash Point: 110.3°C
  • Boiling Point: 338.4°C at 760 mmHg
  • Density: 1.06g/cm3
  • Refractive index: 1.535
  • Safety Statements: Experimental poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Human teratogenic effects by intravenous route: developmental abnormalities of the cardiovascular system. A narcotic analgesic. When heated to decomposition it emits toxic fumes of NOx.
  • Flash Point: 110.3°C
  • EINECS: 201-011-5
  • Molecular Weight: 261.35932
  • InchiKey: UVAZQQHAVMNMHE-UHFFFAOYSA-N
  • InChI: InChI=1S/C16H23NO2/c1-4-15(18)19-16(14-8-6-5-7-9-14)10-11-17(3)12-13(16)
    2/h5-9,13H,4,10-12H2,1-3H3
  • Molecular Formula: C16H23NO2
  • Molecular Structure:CAS No:77-20-3 (1,3-dimethyl-4-phenylpiperidin-4-yl) propanoate

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77-20-3 APRODINE

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
    No. 217 Zhongshan Rd.
    (N)Nanjing 210009,China ,China
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77-20-3 Alphaprodine

  • Alphaprodine, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,China
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77-20-3 Alphaprodine

  • Alphaprodine, 99%
  • China Facus Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-(0)574-62378411
  • Fax: +86-(0)574-62378410
  • Address: 24Fl,Yuanjing Building,Beilun District, Zhejiang 315800 NingboCHINA Ningbo,China
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77-20-3 Alphaprodine

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77-20-3 Alphaprodine

  • Alphaprodine, 99%
  • China Tianjin Pharmacn Science Co., Ltd. [Manufacturer]
  • Tel: 86-22-23359620/ 86-13612042162 (mobile)
  • Fax: 86-22-23359620
  • Address: 1006 Sinochem Building, 707 Lianmeng RD, Shijiazhuang 050061, Hebei, China ,China
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77-20-3 Alphaprodine

  • Alphaprodine
  • China Hallopharma [Manufacturer]
  • Tel: 0086-23-67030808
  • Fax: 0086-23-67030818
  • Address: 17F,Venus Science Incubate Center,No.60 Xingguang Road,New North Zone,401121 ChongqingCHINA Chongqing,China
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77-20-3 Alphaprodine

  • Alphaprodine
  • China Inter-Chemical [Manufacturer]
  • Tel: 0086-23-67030808
  • Fax: 0086-23-67030818
  • Address: 17F,Venus Science Incubate Center,No.60 Xingguang Road,New North Zone,401121 ChongqingCHINA Chongqing,China
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77-20-3 4-Piperidinol,1,3-dimethyl-4-phenyl-, 4-propanoate, (3R,4S)-rel-

  • China TYSChemical Co.,Ltd [Manufacturers]
  • Tel: +8613564162653
  • Fax: 024-23984145
  • Address: Room 602 , NO. 7, Lane 1111, Lijin Road Shanghai CHINA Shanghai,ShanghaiChina
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References of (1,3-dimethyl-4-phenylpiperidin-4-yl) propanoate
Title: Alphaprodine
CAS Registry Number: 77-20-3
CAS Name: (cis)-1,3-Dimethyl-4-phenyl-4-piperidinol propanoate
Synonyms: (±)-a-1,3-dimethyl-4-phenyl-4-piperidinyl propionate; dl-a-1,3-dimethyl-4-phenyl-4-propionoxypiperidine; (±)-a-prodine
Molecular Formula: C16H23NO2
Molecular Weight: 261.36
Percent Composition: C 73.53%, H 8.87%, N 5.36%, O 12.24%
Literature References: Mixture of the two cis isomers of prodine; betaprodine is the mixture of trans isomers. Prepn: J. Lee, A. Ziering, US 2498433 (1950 to Hoffmann-La Roche); A. H. Beckett et al., J. Pharm. Pharmacol. 9, 939 (1957); A. Ziering et al., J. Org. Chem. 22, 1521 (1957). Configurational studies: F. R. Ahmed et al., Chem. Ind. (London) 1959, 485; eidem, ibid. 1962, 97. Stereostructure-activity studies: M. M. Abdel-Monem et al., J. Med. Chem. 15, 494 (1972). Pharmacology and toxicology: G. M. Gruber et al., J. Pharmacol. Exp. Ther. 99, 312 (1950). Review of clinical experience: R. C. Lunt, H. E. Howard, Pediatr. Dent. 10, 121-126 (1988).
 
Derivative Type: Hydrochloride
CAS Registry Number: 561-78-4
Manufacturers' Codes: Nu-1196
Trademarks: Nisentil (Roche)
Molecular Formula: C16H23NO2.HCl
Molecular Weight: 297.82
Percent Composition: C 64.53%, H 8.12%, N 4.70%, O 10.74%, Cl 11.90%
Properties: Crystals from acetone, mp 220-221°. Slightly saline taste. Freely sol in water, alc, chloroform. Practically insol in ether. pH of 1% aq soln 4.5-5.2. LD50 in mice: 54 mg/kg i.v., 73 mg/kg i.p.; in rats: 22 mg/kg i.p. (Gruber).
Melting point: mp 220-221°
Toxicity data: LD50 in mice: 54 mg/kg i.v., 73 mg/kg i.p.; in rats: 22 mg/kg i.p. (Gruber)
 
Derivative Type: Betaprodine hydrochloride
CAS Registry Number: 49638-23-5
Synonyms: (±)-b-Prodine hydrochloride
Manufacturers' Codes: Nu-1779
Properties: Crystals from methyl ethyl ketone, mp 195-196° (Beckett); from acetone + methanol, mp 199-200° (Ziering).
Melting point: mp 195-196° (Beckett); mp 199-200° (Ziering)
 
NOTE: These are controlled substances (opiates): 21 CFR, 1308.11 (betaprodine) and 1308.12 (alphaprodine).
Therap-Cat: Analgesic (narcotic).
Keywords: Analgesic (Narcotic).