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CAS No 77521-29-0 , 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid Search by region : Switzerland

  • Name: 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid
  • Synonyms: 77521-29-0;2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid;ampa; (+/-)-AMPA; (R,S)-AMPA; AMPA (pharmaceutical); 74341-63-2; alpha-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID;
  • CAS Registry Number:
  • Melting Point: 240 °C
  • Density: 1.386 g/cm3
  • Refractive index: 1.541
  • Water Solubility: H2O: 1.2 mg/mL
  • Molecular Weight: 186.1653
  • InchiKey: UUDAMDVQRQNNHZ-UHFFFAOYSA-N
  • InChI: InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,
    10)(H,11,12)
  • Molecular Formula: C7H10N2O4
  • Molecular Structure:CAS No:77521-29-0 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid

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77521-29-0 (RS)-AMPA HYDROBROMIDE

  • Switzerland BIOTREND Chemicals AG [Manufacturer]
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77521-29-0 4-Isoxazolepropanoicacid, a-amino-2,3-dihydro-5-methyl-3-oxo-

  • Switzerland Biotrend Chemicals AG [Importer/Exporter]
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References of 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid
Title: AMPA
CAS Registry Number: 77521-29-0
CAS Name: a-Amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolepropanoic acid
Synonyms: a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
Molecular Formula: C7H10N2O4
Molecular Weight: 186.17
Percent Composition: C 45.16%, H 5.41%, N 15.05%, O 34.38%
Literature References: Synthetic excitatory amino acid that characterizes a specific subset of ionotropic glutamate receptors in the CNS, consequently known as AMPA-receptors. The activity resides primarily in the L-isomer. Prepn: J. J. Hansen, P. Krogsgaard-Larsen, J. Chem. Soc. Perkin Trans. 1 1980, 1826; M. Begtrup, F. A. Slok, Synthesis 1993, 861. Characterization of neuroexcitatory activity: P. Krogsgaard-Larsen et al., Nature 284, 64 (1980). Resolution of enantiomers and stereospecific activity: J. J. Hansen et al., J. Med. Chem. 26, 901 (1983). Review of AMPA receptors: K. Borges, R. Dingledine, Prog. Brain Res. 116, 153-170 (1998); and potential for pharmacological intervention: G. J. Lees, Drugs 59, 33-78 (2000).
Properties: Crystals from water as the monohydrate, mp 252° (dec).
Melting point: mp 252° (dec)
 
Derivative Type: L-AMPA
CAS Registry Number: 83643-88-3
Synonyms: S-AMPA
Properties: Crystals from water + ethanol as the hydrate, gradual decomp above ~200°. [a]D28 -21 ±2° (c = 0.19 in water).
Optical Rotation: [a]D28 -21 ±2° (c = 0.19 in water)