Home > Name List By l > L-Lysine,N-(N-acetylmuramoyl)-L-alanyl-D-a-glutaminyl-N6-(1-oxooctadecyl)- Germany

CAS No 78113-36-7 , L-Lysine,N-(N-acetylmuramoyl)-L-alanyl-D-a-glutaminyl-N6-(1-oxooctadecyl)- Search by region : Germany

  • Name: L-Lysine,N-(N-acetylmuramoyl)-L-alanyl-D-a-glutaminyl-N6-(1-oxooctadecyl)-
  • Synonyms: Nopia; MDP-Lys(L 18); Muroctasine;L-Lysine,N-(N-acetylmuramoyl)-L-alanyl-D-a-glutaminyl-N6-(1-oxooctadecyl)-; 1: PN: WO2009033811PAGE: 103 claimed sequence; Na-Acetylmuramyl-L-alanyl-D-isoglutaminyl-Ne-stearoyl-L-lysine;L-Lysine,N2-[N2-[N-(N-acetylmuramoyl)-L-alanyl]-D-a-glutaminyl]-N6-(1-oxooctadecyl)-; DJ 7041; Muroctasin; Romurtide;
  • CAS Registry Number:
  • Flash Point: 678.6°C
  • Boiling Point: 1198.5°C at 760 mmHg
  • Density: 1.21g/cm3
  • Refractive index: 1.544
  • Safety Statements: WGK Germany 3 RTECS OL5545000
  • Flash Point: 678.6°C
  • Molecular Weight: 887.11
  • InChI: InChI=1/C43H78N6O13/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23-34(52)45-26-21-20-22-32(42(58)59)48-35(53)25-24-31(39(44)55)49-40(56)28(2)46-41(57)29(3)61-38-36(47-30(4)51)43(60)62-33(27-50)37(38)54/h28-29,31-33,36-38,43,50,54,60H,5-27H2,1-4H3,(H2,44,55)(H,45,52)(H,46,57)(H,47,51)(H,48,53)(H,49,56)(H,58,59)/t28-,29+,31+,32+,33+,36+,37+,38+,43?/m0/s1
  • Molecular Formula: C43H78 N6 O13
  • Molecular Structure:CAS No:78113-36-7 L-Lysine,N-(N-acetylmuramoyl)-L-alanyl-D-a-glutaminyl-N6-(1-oxooctadecyl)-

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78113-36-7 romurtide

  • romurtide
  • Germany CHEMOS GmbH [Manufacturer]
  • Tel: 0049 9402/9336 0
  • Fax: 0049 9402/9336 13
  • Address: CHEMOS GmbH
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References of L-Lysine,N-(N-acetylmuramoyl)-L-alanyl-D-a-glutaminyl-N6-(1-oxooctadecyl)-
Title: Romurtide
CAS Registry Number: 78113-36-7
CAS Name: N2-[N2-[N-(N-Acetylmuramoyl)-L-alanyl]-D-a-glutaminyl]-N6-(1-oxooctadecyl)-L-lysine
Synonyms: N2-(N-acetylmuramoyl-L-alanyl-D-isoglutaminyl)-N6-stearoyl-L-lysine; MDP-Lys (L18); muroctasin
Manufacturers' Codes: DJ-7041
Trademarks: Nopia (Daiichi)
Molecular Formula: C43H78N6O13
Molecular Weight: 887.11
Percent Composition: C 58.22%, H 8.86%, N 9.47%, O 23.45%
Literature References: Derivative of muramyl dipeptide, q.v., with immunostimulating activity. Prepn: T. Shiba et al., EP 21367; eidem, US 4317771 (1981, 1982 both to Daiichi Seiyaku). Immunopotentiating effect in vitro: Y. Osada et al., Infect. Immun. 38, 848 (1982); in vivo: K. Matsumoto et al., ibid. 39, 1029 (1983); M. Akasaki et al., Agents Actions 22, 144 (1987). Enzyme immunoassay in plasma: H. Masayasu et al., Chem. Pharm. Bull. 33, 5522 (1985). Supplement on pharmacology, toxicology and clinical studies: Arzneim.-Forsch. 38, Suppl. 7A, 951-1074 (1988). Acute toxicity: Y. Ono et al., ibid. 1022.
Properties: Odorless, tasteless white powder, mp 176-178°. [a]D20 +24.9° (c = 1 in methanol). pKa 5.70. Soly at 20°: DMF 1 g/72 ml; methanol 1 g/190 ml; ethanol 1 g/330 ml. Practically insol in acetone, acetonitrile, chloroform, water. LD50 in male, female mice, male, female rats, dogs (mg/kg): 436, 625, 761, 801, >200 s.c. (Ono).
Melting point: mp 176-178°
pKa: pKa 5.70
Optical Rotation: [a]D20 +24.9° (c = 1 in methanol)
Toxicity data: LD50 in male, female mice, male, female rats, dogs (mg/kg): 436, 625, 761, 801, >200 s.c. (Ono)
Therap-Cat: Immunostimulant.
Keywords: Immunomodulator.