Title: Diazolidinyl Urea
CAS Registry Number: 78491-02-8
CAS Name: N-[1,3-Bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-
N,N￠-bis(hydroxymethyl)urea
Synonyms: N-(hydroxymethyl)-
N-(1,3-dihydroxymethyl-2,5-dioxo-4-imidazolidinyl)-
N￠-(hydroxymethyl)urea
Trademarks: Germall II (Sutton)
Molecular Formula: C8H14N4O7
Molecular Weight: 278.22
Percent Composition: C 34.54%, H 5.07%, N 20.14%, O 40.25%
Literature References: Member of a family of heterocyclic substituted urea compounds with formaldehyde releasing activity. Prepn: P. A. Berke, W. E. Rosen,
WO 8100566;
eidem, US 4271176 (both 1981 to Sutton). Chemistry, toxicity and antimicrobial activity:
eidem, Cosmet. Toiletries 97, 49 (1982). Determn in cosmetic products: R. J. Geise
et al., J. Soc. Cosmet. Chem. 45, 173 (1994). Review of use and safety assessment:
J. Am. Coll. Toxicol. 9, 229-245 (1990).
Properties: Fine, white, free-flowing powder. Sol in water as a 30% soln. Insol in fats. LD50 orally in rats: 2.57 g/kg; dermally in rabbits: >2.0 g/kg (Berke, Rosen).
Toxicity data: LD50 orally in rats: 2.57 g/kg; dermally in rabbits: >2.0 g/kg (Berke, Rosen)
Use: Antimicrobial preservative in cosmetics and toiletries.
