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CAS No 78919-13-8 , Iloprost

  • Name: Iloprost
  • Synonyms: Iloprost;5-(Hexahydro-5-hydroxy-4-(3-hydroxy-4-methyl-1-octen-6-ynyl)-2(1H)-pentalenylidene)pentanoic acid;
  • CAS Registry Number:
  • Melting Point: 115.7 DEG C
  • Flash Point: 294°C
  • Boiling Point: 539.2°C at 760 mmHg
  • Density: 1.21g/cm3
  • Refractive index: 1.629
  • Flash Point: 294°C
  • Molecular Weight: 360.49
  • InChI: InChI=1/C22H32O4/c1-3-4-7-15(2)20(23)11-10-18-19-13-16(8-5-6-9-22(25)26)12-17(19)14-21(18)24/h8,10-11,15,17-21,23-24H,5-7,9,12-14H2,1-2H3,(H,25,26)/b11-10+,16-8+/t15?,17-,18+,19-,20+,21+/m0/s1
  • Molecular Formula: C22H32O4
  • Molecular Structure:CAS No:78919-13-8 Iloprost

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78919-13-8 ILOPROST

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78919-13-8 Iloprost

  • Iloprost
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  • Fax: 0049 9402/9336 13
  • Address: CHEMOS GmbH
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References of Iloprost
Title: Iloprost
CAS Registry Number: 78919-13-8
CAS Name: 5-[Hexahydro-5-hydroxy-4-(3-hydroxy-4-methyl-1-octen-6-ynyl)-2(1H)-pentalenylidene]pentanoic acid
Synonyms: 5-(E)-(1S,5S,6R,7R)-7-hydroxy-6-[(E)-(3S,4RS)-3-hydroxy-4-methyl-1-octenyl]bicyclo[3.3.0]octan-3-ylidenepentanoic acid; (E)-(3aS,4R,5R,6aS)-hexahydro-5-hydroxy-4-[(E)-(3S,4RS)-3-hydroxy-4-methyl-1-octen-6-ynyl]-D2(1H),d-pentalenevaleric acid; ciloprost
Manufacturers' Codes: ZK-36374
Molecular Formula: C22H32O4
Molecular Weight: 360.49
Percent Composition: C 73.30%, H 8.95%, O 17.75%
Literature References: Prostacyclin analog; 1:1 mixture of 16a- and 16b-methyl diastereomers. Prepn: W. Skuballa et al., DE 2845770; eidem, US 4692464 (1980, 1987 both to Schering AG); W. Skuballa, H. Vorbrüggen, Adv. Prostaglandin Thromboxane Leukotriene Res. 11, 299 (1983). Antithrombotic and cardiovascular pharmacology: K. Schr?r et al., Arch. Pharmacol. 316, 252 (1981). Review of clinical pharmacology and pharmacokinetics: S. M. Grant, K. L. Goa, Drugs 43, 889-924 (1992). Clinical study in limb ischemia: J. Dormandy, Therapie 46, 319 (1991); in Raynaud phenomenon: F. M. Wigley et al., Ann. Intern. Med. 120, 199 (1994); in pulmonary hypertension: H. Olschewski et al., N. Engl. J. Med. 347, 322 (2002).
Properties: Colorless oil.
 
Derivative Type: Tromethamine
Trademarks: Endoprost (Italfarmaco); Ilomedin (Schering AG); Ventavis (Schering AG)
Molecular Formula: C22H32O4.C4H11NO3
Molecular Weight: 481.62
Percent Composition: C 64.84%, H 9.00%, O 23.25%, N 2.91%
 
Therap-Cat: Vasodilator (peripheral). In treatment of pulmonary hypertension.
Keywords: Antithrombotic; Vasodilator (Peripheral).