CAS No 79778-41-9 , Phosphonic acid,P,P'-(6-amino-1-hydroxyhexylidene)bis- Search by region : Canada

Name: Phosphonic acid,P,P'-(6-amino-1-hydroxyhexylidene)bis-
Synonyms: 6-Amino-1-hydroxyhexylidene-1,1-bis(phosphonic acid);6-Amino-1-hydroxyhexane-1,1-diphosphonic acid;Nerixia;6-Amino-1-hydroxyhexylidenediphosphonic acid; Neridronate;Phosphonic acid,P,P'-(6-amino-1-hydroxyhexylidene)bis-;Phosphonicacid, (6-amino-1-hydroxyhexylidene)bis- (9CI); Neridronic acid;
CAS Registry Number:79778-41-9
Density: 1.658 g/cm³
Refractive index: 1.569
Hazard Symbols: Xn: Harmful;
Molecular Weight: 318.15
InChI: InChI=1/C6H17NO7P2/c7-5-3-1-2-4-6(8,15(9,10)11)16(12,13)14/h8H,1-5,7H2,(H2,9,10,11)(H2,12,13,14)
Risk Statements: 22
Molecular Formula: C6H19NNaO8P2+
Molecular Structure:

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79778-41-9 Phosphonic acid,P,P'-(6-amino-1-hydroxyhexylidene)bis-

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References of Phosphonic acid,P,P'-(6-amino-1-hydroxyhexylidene)bis-

Title: Neridronic Acid
CAS Registry Number: 79778-41-9
CAS Name: (6-Amino-1-hydroxyhexylidene)bisphosphonic acid
Molecular Formula: C6H17NO7P2
Molecular Weight: 277.15
Percent Composition: C 26.00%, H 6.18%, N 5.05%, O 40.41%, P 22.35%
Literature References: Bisphosphonate antiresorptive agent. Prepn: J. Jary et al., BE 885139; eidem, US 4304734 (both 1981 to Vysoka Skola Chem.-Tech.); and characterization of monosodium salt: M. Neves et al., Nucl. Med. Biol. 29, 329 (2002). Crystal structure: V. M. Coiro, D. Lamba, Acta Crystallogr. C45, 446 (1989). Clinical study in Paget's disease: S. Adami et al., Clin. Exp. Rheumatol. 20, 55 (2002); in osteogenesis imperfecta: idem et al., J. Bone Miner. Res. 18, 126 (2003); in osteoporosis: V. Braga et al., Bone 33, 342 (2003).
Properties: mp 245°.
Melting point: mp 245°

Derivative Type: Monosodium salt
CAS Registry Number: 80729-79-9
Synonyms: Neridronate sodium
Trademarks: Nerixia (Abiogen)
Molecular Formula: C6H16NNaO7P2
Molecular Weight: 299.13
Percent Composition: C 24.09%, H 5.39%, N 4.68%, Na 7.69%, O 37.44%, P 20.71%
Properties: White solid, mp 263-266° (hemihydrate).
Melting point: mp 263-266° (hemihydrate)

Therap-Cat: Bone resorption inhibitor.
Keywords: Bone Resorption Inhibitor; Antiosteoporotic; Antipagetic.