Home > Name List By e > ethyl 4-(8-chloro-5,6-dihydrobenzo[1,2]cyclohepta[2, 4-b]pyridin-11-ylidene)piperidine-1-carboxylate

CAS No 79794-75-5 , ethyl
4-(8-chloro-5,6-dihydrobenzo[1,2]cyclohepta[2,
4-b]pyridin-11-ylidene)piperidine-1-carboxylate

  • Name: ethyl
    4-(8-chloro-5,6-dihydrobenzo[1,2]cyclohepta[2,
    4-b]pyridin-11-ylidene)piperidine-1-carboxylate
  • Synonyms: Claritine; Alavert; Clarityne; Lisino; Bonalerg; Loratidine;ethyl
    4-(8-chloro-5,6-dihydrobenzo[1,2]cyclohepta[2,
    4-b]pyridin-11-ylidene)piperidine-1-carboxylate;Claritin; Clarityn; Fristamin;
  • CAS Registry Number:
  • Transport: 25kgs
  • Flash Point: 275.1ºC
  • Boiling Point: 531.3 ºCat 760 mmHg
  • Density: 1.261 g/cm3
  • Water Solubility: Insoluble
  • Safety Statements: S22;S24/25
  • Hazard Symbols: Xi
  • Flash Point: 275.1ºC
  • Molecular Weight: 382.88322
  • InchiKey: JCCNYMKQOSZNPW-UHFFFAOYSA-N
  • InChI: InChI=1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)
    14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,
    1H3
  • Risk Statements: S22;S24/25
  • Molecular Formula: C22H23ClN2O2
  • Molecular Structure:CAS No:79794-75-5 ethyl<br />4-(8-chloro-5,6-dihydrobenzo[1,2]cyclohepta[2,<br />4-b]pyridin-11-ylidene)piperidine-1-carboxylate

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References of ethyl
4-(8-chloro-5,6-dihydrobenzo[1,2]cyclohepta[2,
4-b]pyridin-11-ylidene)piperidine-1-carboxylate
Title: Loratadine
CAS Registry Number: 79794-75-5
CAS Name: 4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic acid ethyl ester
Synonyms: 11-[N-(ethoxycarbonyl)-4-piperidylidene]-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
Manufacturers' Codes: Sch-29851
Trademarks: Alavert (Wyeth); Claritin (Schering-Plough); Clarityn (Schering-Plough); Clarytin (Schering-Plough); Lisino (Essex)
Molecular Formula: C22H23ClN2O2
Molecular Weight: 382.88
Percent Composition: C 69.01%, H 6.05%, Cl 9.26%, N 7.32%, O 8.36%
Literature References: Nonsedating-type histamine H1-receptor antagonist. Prepn: F. J. Villani, US 4282233 (1981 to Schering); F. J. Villani et al., Arzneim.-Forsch. 36, 1311 (1986). Pharmacology: A. Barnett et al., Agents Actions 14, 590 (1984). Evaluation of CNS effects in humans: C. M. Bradley, A. N. Nicholson, Eur. J. Clin. Pharmacol. 32, 419 (1987). Clinical pharmacokinetics: E. Radwanski et al., J. Clin. Pharmacol. 27, 530 (1987). Clinical trial in allergic rhinitis: R. J. Dockhorn et al., Ann. Allergy 58, 407 (1987); in comparison with terfenadine, q.v.: F. Horak et al., Arzneim.-Forsch. 38, 124 (1988); G. Bruttmann et al., J. Allergy Clin. Immunol. 83, 411 (1989). HPLC determn in plasma: O. Q. P. Yin et al., J. Chromatogr. B 796, 165 (2003). Review of pharmacology and therapeutic efficacy: M. Haria et al., Drugs 48, 617-637 (1994).
Properties: Crystals from acetonitrile, mp 134-136°.
Melting point: mp 134-136°
Therap-Cat: Antihistaminic.
Keywords: Antihistaminic; Tricyclics; Other Tricyclics.