CAS No 80060-09-9 , 1-tert-butyl-3-[4-phenoxy-2,6-di(propan-2-yl)phenyl]thiourea

Title: Diafenthiuron
CAS Registry Number: 80060-09-9
CAS Name: N-[2,6-Bis(1-methylethyl)-4-phenoxyphenyl]-N￠-(1,1-dimethylethyl)thiourea
Synonyms: 1-tert-butyl-3-(2,6-diisopropyl-4-phenoxyphenyl)thiourea
Manufacturers' Codes: CGA-106630
Trademarks: Pegasus (Novartis Agro); Polo (Novartis Agro)
Molecular Formula: C23H32N2OS
Molecular Weight: 384.58
Percent Composition: C 71.83%, H 8.39%, N 7.28%, O 4.16%, S 8.34%
Literature References: Thiourea proinsecticide that acts via its carbodiimide metabolite to inhibit mitochondrial ATPase. Prepn: J. Drabek, M. B?ger, FR 2465720; eidem, US 4939257 (1981, 1990 both to Ciba-Geigy). Properties and insecticidal activity: H. P. Streibert et al., Brighton Crop Prot. Conf. - Pests Dis. 1988, 25. Field trials: H. P. Streibert, D. Kaeding, ibid. 1994, 743. Mechanism of action studies: F. J. Ruder et al., Pestic. Biochem. Physiol. 41, 207 (1991); E. Petroske, J. E. Casida, ibid. 53, 60 (1995).
Properties: Colorless crystals, mp 149.6°. Vapor pressure: 1.8 ′ 10-8 Pa. Soly at 20° (g/100ml): water 0.00005; cyclohexanone 38; xylene 21; hexane 0.8. LD50 in rats (mg/kg): 2068 orally; >2000 dermally; LC50 (14 hr) in rats: 558 mg/m3 by inhalation (Streibert, 1988).
Melting point: mp 149.6°
Toxicity data: LD50 in rats (mg/kg): 2068 orally; >2000 dermally; LC50 (14 hr) in rats: 558 mg/m3 by inhalation (Streibert, 1988)
Use: Insecticide.