Home > Name List By n > N-[3-[(4-amino-6, 7-dimethoxyquinazolin-2-yl)-methylamino]propyl]oxolane-2-carboxamide

CAS No 81403-80-7 , N-[3-[(4-amino-6,
7-dimethoxyquinazolin-2-yl)-methylamino]propyl]oxolane-2-carboxamide

  • Name: N-[3-[(4-amino-6,
    7-dimethoxyquinazolin-2-yl)-methylamino]propyl]oxolane-2-carboxamide
  • Synonyms: Alfuzosine; Alfuzosina [Spanish];Alfuzosinum; Alfuzosina; Alfuzosine [French]; Alfuzosinum [Latin]; Alfusosine;N-[3-[(4-amino-6,
    7-dimethoxyquinazolin-2-yl)-methylamino]propyl]oxolane-2-carboxamide; 81403-80-7; alphuzosine;
  • CAS Registry Number:
  • Flash Point: °C
  • Boiling Point: °Cat760mmHg
  • Density: 1.272g/cm3
  • Refractive index: 1.62
  • Safety Statements: R20/21/22
  • Flash Point: °C
  • Molecular Weight: 389.44878
  • InchiKey: WNMJYKCGWZFFKR-UHFFFAOYSA-N
  • InChI: InChI=1S/C19H27N5O4/c1-24(8-5-7-21-18(25)14-6-4-9-28-14)19-22-13-11-16
    (27-3)15(26-2)10-12(13)17(20)23-19/h10-11,14H,4-9H2,1-3H3,(H,21,25)(H2,
    20,22,23)
  • Risk Statements: S36/37
  • Molecular Formula: C19H27N5O4
  • Molecular Structure:CAS No:81403-80-7 N-[3-[(4-amino-6,<br />7-dimethoxyquinazolin-2-yl)-methylamino]propyl]oxolane-2-carboxamide

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References of N-[3-[(4-amino-6,
7-dimethoxyquinazolin-2-yl)-methylamino]propyl]oxolane-2-carboxamide
Title: Alfuzosin
CAS Registry Number: 81403-80-7
CAS Name: N-[3-[(4-Amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydro-2-furancarboxamide
Synonyms: N1-(4-amino-6,7-dimethoxyquinazol-2-yl)-N1-methyl-N2-(tetrahydrofuroyl-2)-propylenediamine
Manufacturers' Codes: SL-77.499
Molecular Formula: C19H27N5O4
Molecular Weight: 389.45
Percent Composition: C 58.60%, H 6.99%, N 17.98%, O 16.43%
Literature References: a1-Adrenoceptor antagonist structurally similar to prazosin, q.v. Prepn: P. M. J. Manoury, DE 2904445; idem, US 4315007 (1979, 1982 both to Synthelabo); and antihypertensive activity in rats: P. M. Manoury et al., J. Med. Chem. 29, 19 (1986). Pharmacology: A. G. Ramage, Eur. J. Pharmacol. 129, 307 (1986). HPLC determn in biological fluids: P. Guinebault et al., J. Chromatogr. 353, 361 (1986). Pharmacology in humans: A. H. Deering, Br. J. Clin. Pharmacol. 25, 417 (1988). Clinical evaluation in essential hypertension: S. Leto Di Priolo et al., Eur. J. Clin. Pharmacol. 35, 25 (1988); A. K. Ghosh, S. Ghosh, Ger. Cardiovasc. Med. 1, 81 (1988). Clinical trial in benign prostatic hyperplasia (BPH): C. G. Roehrborn et al., BJU Int. 92, 257 (2003). Review of clinical experience in BPH: D. M. Weiner, F. C. Lowe, Expert Opin. Pharmacother. 4, 2057-2063 (2003).
 
Derivative Type: Hydrochloride
CAS Registry Number: 81403-68-1
Manufacturers' Codes: SL-77.499-10
Trademarks: Mittoval (Schering AG); Urion (Zambon); UroXatral (Sanofi-Synthelabo); Xatral (Sanofi-Synthelabo)
Molecular Formula: C19H27N5O4.HCl
Molecular Weight: 425.91
Percent Composition: C 53.58%, H 6.63%, N 16.44%, O 15.03%, Cl 8.32%
Properties: Crystals from ethanol + ether, mp 225° (Manoury, 1986), also reported earlier as mp 235° (dec) (Manoury, 1982). pKa 8.13.
Melting point: mp 225° (Manoury, 1986); mp 235° (dec) (Manoury, 1982)
pKa: pKa 8.13
 
Therap-Cat: Antihypertensive. In treatment of benign prostatic hypertrophy.
Keywords: Antihypertensive; Quinazoline Derivatives; Antiprostatic Hypertrophy; a-Adrenergic Blocker.