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CAS No 81655-41-6 , 3,3,3-trifluoro-2-methoxy-2-phenylpropanoic acid Search by region : Germany

  • Name: 3,3,3-trifluoro-2-methoxy-2-phenylpropanoic acid
  • Synonyms: 3,3,3-trifluoro-2-methoxy-2-phenylpropanoic acid; SBB000723; 3,3,3-Trifluoro-2-methoxy-2-phenylpropanoic acid;MTPA; alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid;
  • CAS Registry Number:
  • Melting Point: 41-46 °C(lit.)
  • Flash Point: >230 °F
  • Boiling Point: 95-98 °C0.05 mm Hg(lit.)
  • Density: 1.345g/cm3
  • Refractive index: n20/D 1.476(lit.)
  • Safety Statements: R36/37/38:Irritatingtoeyes,respiratorysystemandskin.;
  • Hazard Symbols: Xi
  • Flash Point: >230 °F
  • Molecular Weight: 234.17187
  • InchiKey: JJYKJUXBWFATTE-UHFFFAOYSA-N
  • InChI: InChI=1S/C10H9F3O3/c1-16-9(8(14)15,10(11,12)13)7-5-3-2-4-6-7/h2-6H,1H3,
    (H,14,15)
  • Risk Statements: S26:Incaseofcontactwitheyes,rinseimmediatelywithplentyofwaterandseekmedicaladvice.;S36:Wearsuitableprotectiveclothing.;
  • Molecular Formula: C10H9F3O3
  • Molecular Structure:CAS No:81655-41-6 3,3,3-trifluoro-2-methoxy-2-phenylpropanoic acid

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81655-41-6 (+/-)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)PHENYLACETIC ACID; 97%

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References of 3,3,3-trifluoro-2-methoxy-2-phenylpropanoic acid
Title: Mosher's Reagent
CAS Registry Number: 81655-41-6
CAS Name: a-Methoxy-a-(trifluoromethyl)benzeneacetic acid
Synonyms: (±)-Mosher's acid; MTPA; 2-methoxy-2-(trifluoromethyl)phenylacetic acid
Molecular Formula: C10H9F3O3
Molecular Weight: 234.17
Percent Composition: C 51.29%, H 3.87%, F 24.34%, O 20.50%
Literature References: Chiral derivatizing reagent. Prepn: D. L. Dull, H. S. Mosher, J. Am. Chem. Soc. 89, 4230 (1967); J. A. Dale et al., J. Org. Chem. 34, 2543 (1969). Microscale prepn: D. E. Ward, C. K. Rhee, Tetrahedron Lett. 32, 7165 (1991). Absolute configuration: S. S. Oh et al., J. Org. Chem. 54, 4499 (1989); of the acid chloride: B. S. Joshi, S. W. Pelletier, Heterocycles 51, 183 (1999). Enantiomeric purity of commerical samples: W. A. K?nig et al., Tetrahedron Lett. 31, 6867 (1990). Use in determn of abs config: T. R. Hoye, M. K. Renner, J. Org. Chem. 61, 2056 (1996); A. Ichikawa, Enantiomer 3, 255 (1998); L. F. Tietze et al., Eur. J. Org. Chem. 2000, 2247.
 
Derivative Type: (R)-(+)-Form
CAS Registry Number: 20445-31-2
Properties: bp1.5 mm 116-118°. [a]D25 +68.5 ± 1.3° (c = 1.49 in CH3OH).
Boiling point: bp1.5 mm 116-118°
Optical Rotation: [a]D25 +68.5 ± 1.3° (c = 1.49 in CH3OH)
 
Derivative Type: (S)-(-)-Form
CAS Registry Number: 17257-71-5
Properties: bp1.5 mm 115-117°. [a]D24 -71.8± 0.6° (c = 3.28 in CH3OH).
Boiling point: bp1.5 mm 115-117°
Optical Rotation: [a]D24 -71.8± 0.6° (c = 3.28 in CH3OH)
 
Derivative Type: (R)-(-)-Acid chloride
CAS Registry Number: 39637-99-5
Synonyms: (R)-MTPA-chloride
Properties: bp1 mm 54-56°. [a]D25 -10.0± 0.1° (neat, l = 1).
Boiling point: bp1 mm 54-56°
Optical Rotation: [a]D25 -10.0± 0.1° (neat, l = 1)
 
Derivative Type: (S)-(+)-Acid chloride
CAS Registry Number: 20445-33-4
Properties: bp1 mm 54-56°. [a]D24 +129.0± 0.2° (c = 5.17 in CCl4).
Boiling point: bp1 mm 54-56°
Optical Rotation: [a]D24 +129.0± 0.2° (c = 5.17 in CCl4)
 
Use: Resolution of enantiomers primarily of alcohols and amines.