Home > Name List By 2 > 2-[4-[1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butyl] phenyl]-2-methylpropanoic acid

CAS No 83799-24-0 , 2-[4-[1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butyl]
phenyl]-2-methylpropanoic acid

  • Name: 2-[4-[1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butyl]
    phenyl]-2-methylpropanoic acid
  • Synonyms: Terfenadine-COOH; Allegra;Carboxyterfenadine; Fexofenadine [INN:BAN]; Fexofendine; Terfenadine acid metabolite;2-[4-[1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butyl]
    phenyl]-2-methylpropanoic acid; Terfenadine carboxylate;
  • CAS Registry Number:
  • Melting Point: 218-220 °C
  • Flash Point: 375.5 °C
  • Boiling Point: 697.3 °C at 760 mmHg
  • Density: 1.171 g/cm3
  • Refractive index: 1.596
  • Flash Point: 375.5 °C
  • Molecular Weight: 501.65636
  • InchiKey: RWTNPBWLLIMQHL-UHFFFAOYSA-N
  • InChI: InChI=1S/C32H39NO4/c1-31(2,
    30(35)36)25-17-15-24(16-18-25)29(34)14-9-21-33-22-19-28(20-23-33)32(37,
    26-10-5-3-6-11-26)27-12-7-4-8-13-27/h3-8,10-13,15-18,28-29,34,37H,9,14,
    19-23H2,1-2H3,(H,35,36)
  • Molecular Formula: C32H39NO4
  • Molecular Structure:CAS No:83799-24-0 2-[4-[1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butyl]<br />phenyl]-2-methylpropanoic acid

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References of 2-[4-[1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butyl]
phenyl]-2-methylpropanoic acid
Title: Fexofenadine
CAS Registry Number: 83799-24-0
CAS Name: a,a-Dimethyl-4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]benzeneacetic acid
Synonyms: carboxyterfenadine; terfenadine carboxylate
Manufacturers' Codes: MDL-16455
Molecular Formula: C32H39NO4
Molecular Weight: 501.66
Percent Composition: C 76.61%, H 7.84%, N 2.79%, O 12.76%
Literature References: Nonsedating-type histamine H1-receptor antagonist. Prepn: A.A. Carr et al., DE 3007498; eidem, US 4254129 (1980, 1981 both to Richardson-Merrell). Identification as active metabolite of terfenadine, q.v.: D. A. Garteiz et al., Arzneim.-Forsch. 32, 1185 (1982). Synthesis: S. H. Kawai et al., J. Org. Chem. 59, 2620 (1994). HPLC separation from terfenadine: K. Y. Chan et al., J. Chromatogr. 571, 291 (1991); determn in biological fluids: A. Terhechte, G. Blaschke, ibid. A 694, 219 (1995). Effects on cardiac K+ channels: D. Rampe et al., Mol. Pharmacol. 44, 1240 (1993). Comparative analysis of cardiotoxic potential: J. A. Hey et al., Arzneim.-Forsch. 46, 153 (1996). Clinical pharmacology in children: F. E. R. Simons et al., J. Allergy Clin. Immunol. 98, 1062 (1996).
Properties: Crystals from methanol-butanone, mp 195-197° (Carr); also reported as white crystals from methanol, mp 142-143° (Kawai).
Melting point: mp 195-197° (Carr); mp 142-143° (Kawai)
 
Derivative Type: Hydrochloride
CAS Registry Number: 153439-40-8
Trademarks: Allegra (Aventis); Telfast (Aventis)
Molecular Formula: C32H39NO4.HCl
Molecular Weight: 538.12
Percent Composition: C 71.42%, H 7.49%, N 2.60%, O 11.89%, Cl 6.59%
 
Therap-Cat: Antihistaminic.
Keywords: Antihistaminic.