Home > Name List By l > Lisinopril

CAS No 83915-83-7 , Lisinopril

  • Name: Lisinopril
  • Synonyms: Lisinopril;(S)-1-(N2-(1-Carboxy-3-phenylpropyl)-L-lysyl)-L-proline dihydrate;
  • CAS Registry Number:
  • Melting Point: 148 °C
  • Density: 1.251 g/cm3
  • Refractive index: -45 ° (C=1, 0.25mol/L Zinc Acetate Buffer)
  • Safety Statements: S22;S24/25
  • Hazard Symbols: Xi,Xn
  • EINECS: 278-488-1
  • Molecular Weight: 441.52
  • InChI: InChI=1S/C21H31N3O5/c22-13-5-4-9-16(19(25)24-14-6-10-18(24)21(28)29)23-17(20(26)27)12-11-15-7-2-1-3-8-15/h1-3,7-8,16-18,23H,4-6,9-14,22H2,(H,26,27)(H,28,29)/t16-,17-,18-/m0/s1
  • Risk Statements: S22;S24/25
  • Molecular Formula: C21H31O5N3.2(H2O)
  • Molecular Structure:CAS No:83915-83-7 Lisinopril

Related products

Search by region :

Select to

83915-83-7 LISINOPRIL

  • China SINOCHEM NINGBO LTD. [Manufacturer]
  • Tel: +86-574-87260209/ +86-574-87348868
  • Fax: +86-574-87342797, 87262630
  • Address: 21 Jiangxia St., Ningbo 315000
    Zhejiang China null,nullChina
Contact Supplier

83915-83-7 Lisinopril

  • India THEMADRASPHARMACEUTICALS [Manufacturers]
  • Tel: 91 - 44 - 23452030- 34
  • Fax: 91-44-823-4013
  • Address: #137- B Old Mahabalipuram Road, Karapakkam,Chennai - 600 096, India null,nullIndia
Contact Supplier

83915-83-7 Lisinopril

  • Taiwan TAIWANPANBIOTICLABORATORIESCO.,LTD. [Manufacturers]
  • Tel: 886-7-7317861
  • Fax: 886-7-7316002
  • Address: No.5-1, Ta Tong Rd, Niao Sung Hsiang, Kaohsiung Hsieng, Taiwan. R.O.C. null,HsiengTaiwan
Contact Supplier

83915-83-7 Lisinopril Dihydrate

  • China Yingkou Sanzheng Organic Chemical Co. Ltd. [Manufacturers]
  • Tel: +86-(417)-3635156
  • Fax: +86-(417)-3635157
  • Address: 25 Gengxinli Village, Daqing Road, Zhanqian District, Yingkou City, Liaoning Province 115001, null,LiaoningChina
Contact Supplier

83915-83-7 Lisinopril

Contact Supplier

83915-83-7 Lisinopril

  • Spain FARMHISPANIA, S. A. [Manufacturers]
  • Tel: +34 93 451 18 37
  • Fax: +34 93 451 81 26
  • Address: Balmes 85, 3rd floor 08008 Barcelona Barcelona,BarcelonaSpain
Contact Supplier

83915-83-7 Lisinopril

Contact Supplier

83915-83-7 Lisinopril

  • China Tai zhou world Pharm & Chem Co., Ltd_ [Manufacturers]
  • Tel: 0576-85301198
  • Fax: 0576-85308398
  • Address: Rome 1001,wangjiang plaza,unti 2,jinshan east Road linhai,zhejiang,china linhai,zhejiangChina
Contact Supplier

83915-83-7 Lisinopril

  • China Shanxi Haitai Electronic Material Co., Ltd. [Manufacturers]
  • Tel: +86-359-338 8400
  • Fax: +86-359-338 8418
  • Address: East side of Gongyedadao(south), Fenglingdu development zone, Yuncheng, Shanxi, China Yuncheng,ShanxiChina
Contact Supplier

83915-83-7 Lisinopril

Contact Supplier

Select to

8/9
Previous 1 2 3 4 5 6 7 8 9 Next
References of Lisinopril
Title: Lisinopril
CAS Registry Number: 83915-83-7
CAS Name: (S)-1-[N2-(1-Carboxy-3-phenylpropyl)-L-lysyl]-L-proline dihydrate
Manufacturers' Codes: MK-521
Trademarks: Acerbon (AstraZeneca); Alapril (Mediolanum); Carace (BMS); Coric (BMS); Novatec (Merck & Co.); Prinil (Merck & Co.); Prinivil (Merck & Co.); Vivatec (Merck & Co.); Zestril (AstraZeneca)
Molecular Formula: C21H31N3O5.2H2O
Molecular Weight: 441.52
Percent Composition: C 57.13%, H 7.99%, N 9.52%, O 25.37%
Literature References: Orally active angiotensin-converting enzyme (ACE) inhibitor. Prepn: A. A. Patchett et al., EP 12401; E. E. Harris et al., US 4374829 (1980, 1983 both to Merck & Co.); M. T. Wu et al., J. Pharm. Sci. 74, 352 (1985). Comprehensive description: D. P. Ip et al., Anal. Profiles Drug Subs. Excip. 21, 233-276 (1992). HPLC determn in urine: Y. C. Wong, B. G. Charles, J. Chromatogr. B 673, 306 (1995). Series of articles in hypertension and congestive heart failure: Am. J. Med. 85, Suppl. 3B, 1-59 (1988). Review of clinical efficacy in myocardial infarction: K. L. Goa et al., Drugs 52, 564-588 (1996). Clinical trial in diabetic retinopathy: N. Chaturvedi et al., Lancet 351, 28 (1998).
Properties: White to off-white crystalline, odorless powder. pKa1 (25°) 2.5; pKa2 4.0; pKa3 6.7; pKa4 10.1. Approx uv max (0.1N NaOH): 246, 254, 258, 261, 267 nm (A1%1cm 4.0, 4.5, 5.1, 5.1, 3.7); (0.1N HCl): 246, 253, 258, 264, 267 nm (A1%1cm 3.2, 3.9, 4.5, 3.0, 2.8). [a]25405 -120° (c = 1 in 0.25M pH 6.4 zinc acetate); [a]25436 -96° (c = 1 in 0.25M pH 6.4 zinc acetate). Partition coefficient at room temp (n-octanol/0.1M pH 7 phosphate buffer): 10.2 ±0.5. Soly (mg/ml): water 97; methanol 14; ethanol <0.1; acetone <0.1; acetonitrile <0.1; chloroform <0.1; DMF <0.1.
pKa: pKa1 (25°) 2.5; pKa2 4.0; pKa3 6.7; pKa4 10.1
Optical Rotation: [a]25405 -120° (c = 1 in 0.25M pH 6.4 zinc acetate); [a]25436 -96° (c = 1 in 0.25M pH 6.4 zinc acetate)
Log P: Partition coefficient at room temp (n-octanol/0.1M pH 7 phosphate buffer): 10.2 ±0.5
Absorption maximum: uv max (0.1N NaOH): 246, 254, 258, 261, 267 nm (A1%1cm 4.0, 4.5, 5.1, 5.1, 3.7)
 
Derivative Type: Mixture with hydrochlorothiazide
Trademarks: Prinzide (Merck & Co.); Zestoretic (AstraZeneca)
 
Therap-Cat: Antihypertensive.
Keywords: ACE-Inhibitor; Antihypertensive; N-Carboxyalkyl (peptide/lactam) Derivatives.