Home > Name List By other > (8S,11R,13S,14S, 17S)-11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-17-prop-1-ynyl-1, 2,6,7,8,11,12,14,15,16-decahydrocyc...

CAS No 84371-65-3 , (8S,11R,13S,14S,
17S)-11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-17-prop-1-ynyl-1,
2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one

  • Name: (8S,11R,13S,14S,
    17S)-11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-17-prop-1-ynyl-1,
    2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
  • Synonyms: RU-486;Mifeprex; Mifepriston; RU486; Corlux; Mifepristonum [Latin]; 84371-65-3; Mifepristona [Spanish]; Mifegyne;(8S,11R,13S,14S,
    17S)-11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-17-prop-1-ynyl-1,
    2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one;
  • CAS Registry Number:
  • Density: 1.18 g/cm3
  • Refractive index: 1.623
  • Water Solubility: Soluble to 100 mM in DMSO and to 50 mM in Ethanol
  • Safety Statements: 53-22-36/37/39-45
  • Hazard Symbols: T: Toxic;
  • Molecular Weight: 429.5937
  • InchiKey: VKHAHZOOUSRJNA-GCNJZUOMSA-N
  • InChI: InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23
    (20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,
    32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
  • Risk Statements: 60-61
  • Molecular Formula: C29H35NO2
  • Molecular Structure:CAS No:84371-65-3 (8S,11R,13S,14S,<br />17S)-11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-17-prop-1-ynyl-1,<br />2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one

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References of (8S,11R,13S,14S,
17S)-11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-17-prop-1-ynyl-1,
2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
Title: Mifepristone
CAS Registry Number: 84371-65-3
CAS Name: (11b,17b)-11-[4-(Dimethylamino)phenyl]-17-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one
Synonyms: 11b-[4-(N,N-dimethylamino)phenyl]-17a-(prop-1-ynyl)-D4,9-estradiene-17b-ol-3-one
Manufacturers' Codes: RU-486; RU-38486
Trademarks: Mifegyne (HMR)
Molecular Formula: C29H35NO2
Molecular Weight: 429.59
Percent Composition: C 81.08%, H 8.21%, N 3.26%, O 7.45%
Literature References: Progesterone receptor antagonist with partial agonist activity. Prepn: J. G. Teutsch et al., EP 57115; eidem, US 4386085 (1982, 1983 both to Roussel-UCLAF). Pharmacology: W. Herrmann et al., C.R. Seances Acad. Sci. Ser. 3 294, 933 (1982). Pituitary and adrenal responses in primates: D. L. Healy et al., J. Clin. Endocrinol. Metab. 57, 863 (1983). Mechanism of action study: M. Rauch et al., Eur. J. Biochem. 148, 213 (1985). Clinical study as abortifacient: B. Couzinet et al., N. Engl. J. Med. 315, 1565 (1986); as postcoital contraceptive: A. Glasier et al., ibid. 327, 1041 (1992). Review of mechanism of action and clinical applications: E. E. Baulieu, Science 245, 1351-1357 (1989). Reviews: I. M. Spitz, C. W. Bardin, N. Engl. J. Med. 329, 404-412 (1993); R. N. Brogden et al., Drugs 45, 384-409 (1993).
Properties: mp 150°. [a]D20 +138.5° (c = 0.5 in chloroform).
Melting point: mp 150°
Optical Rotation: [a]D20 +138.5° (c = 0.5 in chloroform)
Therap-Cat: Abortifacient.
Keywords: Abortifacient/Interceptive.