Home > Name List By other > [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1- ylethoxy)phenyl]methanone

CAS No 84449-90-1 , [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-
ylethoxy)phenyl]methanone

  • Name: [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-
    ylethoxy)phenyl]methanone
  • Synonyms: 84449-90-1;Keoxifene; Raloxifeno [Spanish]; Raloxifene Hcl;[6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-
    ylethoxy)phenyl]methanone; Raloxifeno; Raloxifenum; LY 139481; Raloxifenum [Latin];
  • CAS Registry Number:
  • Density: 1.289 g/cm3
  • Water Solubility: DMSO: 28 mg/mL, soluble
  • Molecular Weight: 473.58328
  • InchiKey: GZUITABIAKMVPG-UHFFFAOYSA-N
  • InChI: InChI=1S/C28H27NO4S/c30-21-8-4-20(5-9-21)28-26(24-13-10-22(31)18-25(24)
    34-28)27(32)19-6-11-23(12-7-19)33-17-16-29-14-2-1-3-15-29/h4-13,18,
    30-31H,1-3,14-17H2
  • Molecular Formula: C28H27NO4S
  • Molecular Structure:CAS No:84449-90-1 [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-<br />ylethoxy)phenyl]methanone

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References of [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-
ylethoxy)phenyl]methanone
Title: Raloxifene
CAS Registry Number: 84449-90-1
CAS Name: [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone
Synonyms: keoxifene
Manufacturers' Codes: LY-139481
Molecular Formula: C28H27NO4S
Molecular Weight: 473.58
Percent Composition: C 71.01%, H 5.75%, N 2.96%, O 13.51%, S 6.77%
Literature References: Nonsteroidal, selective estrogen receptor modulator (SERM). Prepn: C. D. Jones, EP 62503; idem, US 4418068 (1982, 1983 both to Lilly); idem et al., J. Med. Chem. 27, 1057 (1984). Review of pharmacology and toxicology: J. Buelke-Sam et al., Reprod. Toxicol. 12, 217-221 (1998); of clinical pharmacology and pharmacokinetics: D. Hochner-Celnikier, Eur. J. Obstet. Gynecol. Reprod. Biol. 85, 23-29 (1999); of clinical efficacy in osteoporosis: D. Agnusdei, ibid. 43-46. Clinical effect on risk of breast cancer: S. R. Cummings et al., J. Am. Med. Assoc. 281, 2189 (1999); on reduction of fracture risk: B. Ettinger et al., ibid. 282, 637 (1999).
Properties: Crystals from acetone, mp 143-147°. uv max (ethanol): 290 nm (e 34000).
Melting point: mp 143-147°
Absorption maximum: uv max (ethanol): 290 nm (e 34000)
 
Derivative Type: Hydrochloride
CAS Registry Number: 82640-04-8
Manufacturers' Codes: LY-156758
Trademarks: Evista (Lilly)
Molecular Formula: C28H27NO4S.HCl
Molecular Weight: 510.04
Percent Composition: C 65.94%, H 5.53%, N 2.75%, O 12.55%, S 6.29%, Cl 6.95%
Properties: Crystals from methanol/water, mp 258°. uv max (ethanol): 286 nm (e 32800).
Melting point: mp 258°
Absorption maximum: uv max (ethanol): 286 nm (e 32800)
 
Therap-Cat: Antiosteoporotic.
Keywords: Antiosteoporotic; Selective Estrogen Receptor Modulator (SERM).