Home > Name List By 7 > 7-chloro-3-hydroxy-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one

CAS No 846-50-4 , 7-chloro-3-hydroxy-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one

  • Name: 7-chloro-3-hydroxy-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one
  • Synonyms: Signopam; Restoril;7-chloro-3-hydroxy-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one; Euhypnos; Methyloxazepam;Crisonar; Oxydiazepam; Hydroxydiazepam; Levanxol; Levanxene;
  • CAS Registry Number:
  • Transport: UN 1230 3/PG 2
  • Flash Point: 11 °C
  • Boiling Point: 549.9°C at 760 mmHg
  • Density: 1.34g/cm3
  • Refractive index: 1.653
  • Safety Statements: Poison by ingestion and intraperitoneal routes. Human systemic effects by ingestion: muscle weakness and changes in the structure or function of the salivary glands. A tranquilizer. When heated to decomposition it emits toxic fumes of Cl and NOx. See also DIAZEPAM.
  • Hazard Symbols: Xn,T,F
  • Flash Point: 11 °C
  • EINECS: 212-688-1
  • Molecular Weight: 300.73962
  • InChI: InChI=1S/C16H13ClN2O2/c1-19-13-8-7-11(17)9-12(13)14(18-15(20)16(19)21)
  • Risk Statements: 22-39/23/24/25-23/24/25-11
  • Molecular Formula: C16H13ClN2O2
  • Molecular Structure:CAS No:846-50-4 7-chloro-3-hydroxy-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one
References of 7-chloro-3-hydroxy-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one
Title: Temazepam
CAS Registry Number: 846-50-4
CAS Name: 7-Chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one
Synonyms: 3-hydroxydiazepam; N-methyloxazepam; oxydiazepam
Manufacturers' Codes: ER-115; K-3917; Ro-5-5345; Wy-3917
Trademarks: Euhypnos (Sigma); Euipnos (Farmitalia); Gelthix (Kerfoot); Levanxene (Montedison); Levanxol (Montedison); Normison (Wyeth); Perdorm (Lagap); Planum (Farmitalia); Remestan (Wyeth); Restoril (Novartis)
Molecular Formula: C16H13ClN2O2
Molecular Weight: 300.74
Percent Composition: C 63.90%, H 4.36%, Cl 11.79%, N 9.31%, O 10.64%
Literature References: Pharmacologically active metabolite of diazepam, q.v. Prepn: S. C. Bell, S. J. Childress, J. Org. Chem. 27, 1691 (1962); S. C. Bell, US 3197467 (1965 to Am. Home. Prod.). See also: E. Reeder et al., US 3340253 and US 3374225 (1967, 1968, both to Hoffmann-La Roche). Metabolism: H. J. Schwandt et al., Xenobiotica 4, 733 (1974); S. H. Curry et al., Br. J. Pharmacol. 57, 427P (1976). Pharmacology: L. O. Randall et al., Arch. Int. Pharmacodyn. 185, 135 (1970); S. Garattini et al., "Metabolic Studies on Benzodiazepines in Various Animal Species" in Benzodiazepines, S. Garattini, Ed. (Raven Press, New York, 1973) pp 73-97. Pharmacology and toxicity study: L. O. Randall et al., Curr. Ther. Res. 7, 590 (1965). Clinical study: P. Sarteschi et al., Arzneim.-Forsch. 22, 93 (1972). Review of pharmacology and therapeutic efficacy: R. C. Heel et al., Drugs 21, 321-340 (1981).
Properties: Crystals from cyclohexane, mp 119-121°.
Melting point: mp 119-121°
NOTE: This is a controlled substance (depressant): 21 CFR, 1308.14.
Therap-Cat: Sedative, hypnotic.
Keywords: Sedative/Hypnotic; Benzodiazepine Derivatives.