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CAS No 848-75-9 , 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-3H-1,
4-benzodiazepin-2-one

  • Name: 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-3H-1,
    4-benzodiazepin-2-one
  • Synonyms: Methyllorazepam; Noctamid; CHEBI:52993; Ro 5-5516; Loramet; WY 4082; Lormetazepamum [INN-Latin];7-chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-3H-1,
    4-benzodiazepin-2-one; N-Methyllorazepam;
  • CAS Registry Number:
  • Transport: 3249
  • Density: 1.44 g/cm3
  • Refractive index: 1.665
  • Safety Statements: Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Cl− and NOx. Note: This is a controlled substance (depressant) listed in the U.S. Code of Federal Regulations, Title 21 Part 1308.14 (1985).
  • EINECS: 212-700-5
  • Molecular Weight: 335.18468
  • InchiKey: FJIKWRGCXUCUIG-UHFFFAOYSA-N
  • InChI: InChI=1S/C16H12Cl2N2O2/c1-20-13-7-6-9(17)8-11(13)14(19-15(21)16(20)22)
    10-4-2-3-5-12(10)18/h2-8,15,21H,1H3
  • Molecular Formula: C16H12Cl2N2O2
  • Molecular Structure:CAS No:848-75-9 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-3H-1,<br />4-benzodiazepin-2-one
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848-75-9 LORMETAZEPAM

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
    No. 217 Zhongshan Rd.
    (N)Nanjing 210009,China ,China
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848-75-9 LORMETAZEPAM

  • India JAI RADHE SALES []
  • Fax: 0091-79-26569884
  • Address: 309/310 HARIKRUPA TOWER,NR.OLD SHARDA MANDIR CHAR RASTA,ELLISBRIDGE ,AHMEDABAD,GUJRAT , INDIA. ,India
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848-75-9 Lormetazepam

  • India Shreeji Pharma International [Manufacturers]
  • Tel: +91-265-3019110
  • Fax: +91-265-2465036
  • Address: FF/10, Narsinghdham Complex, Sangam Chararasta, Harni Road, Vadodara, Gujarat 390018, Vadodara,GujaratIndia
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848-75-9 LORMETAZEPAM (HYPNOTIC)

  • United States Cambrex Corporation [Manufacturer]
  • Tel: 866-286-9133/ 201-804-3031
  • Address: Cambrex Corporation
    One Meadowlands Plaza
    East Rutherford, New Jersey 07073 ,United States
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References of 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-3H-1,
4-benzodiazepin-2-one
Title: Lormetazepam
CAS Registry Number: 848-75-9
CAS Name: 7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one
Synonyms: N-methyllorazepam
Manufacturers' Codes: Wy-4082
Trademarks: Ergocalm (Teofarma); Loramet (Wyeth); Noctamid (Schering AG)
Molecular Formula: C16H12Cl2N2O2
Molecular Weight: 335.18
Percent Composition: C 57.33%, H 3.61%, Cl 21.15%, N 8.36%, O 9.55%
Literature References: Analog of lorazepam, q.v. Prepn: S. C. Bell, BE 621819 C.A. 60, 2993b (1964); idem, US 3296249 (1963, 1967 both to Am. Home Products); idem, J. Med. Chem. 11, 457 (1968); A. Nudelman et al., J. Pharm. Sci. 63, 1886 (1974). Pharmacokinetics and biotransformation in humans: M. Hümpel et al., Eur. J. Drug Metab. Pharmacokinet. 4, 237 (1979). Hypnotic effect: A. Doenicke et al., Anaesthesist 28, 578 (1979). Comparative study: H. Ott et al., ibid. 29. Absorption, distribution, excretion of 14C-lormetazepam: R. Girkin et al., Xenobiotica 10, 401 (1980). Radioimmunologic study: M. Hümpel et al., Clin. Pharmacol. Ther. 28, 673 (1980).
Properties: Crystals from ethanol/THF, mp 205-207°.
Melting point: mp 205-207°
NOTE: This is a controlled substance (depressant): 21 CFR, 1308.14.
Therap-Cat: Sedative, hypnotic.
Keywords: Sedative/Hypnotic; Benzodiazepine Derivatives.