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CAS No 85622-93-1 , 3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide

  • Name: 3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide
  • Synonyms: Temozolamide; 85622-93-1; Temodar;Methazolastone; Temozolomidum [Latin];3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide; Temozolodida [Spanish]; CCRG-81045; Temodal;
  • CAS Registry Number:
  • Density: 1.97 g/cm3
  • Safety Statements: 24/25-45-36/37-26-53
  • Hazard Symbols: T: Toxic;Xi: Irritant;
  • Molecular Weight: 194.15084
  • InchiKey: BPEGJWRSRHCHSN-UHFFFAOYSA-N
  • InChI: InChI=1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,
    13)
  • Risk Statements: 45-46-60-61-22-36/37/38
  • Molecular Formula: C6H6N6O2
  • Molecular Structure:CAS No:85622-93-1 3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide

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References of 3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide
Title: Temozolomide
CAS Registry Number: 85622-93-1
CAS Name: 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide
Synonyms: 8-carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one; methazolastone
Manufacturers' Codes: M & B 39831; CCRG-81045; NSC-362856
Trademarks: Temodal (Schering-Plough); Temodar (Schering-Plough)
Molecular Formula: C6H6N6O2
Molecular Weight: 194.15
Percent Composition: C 37.12%, H 3.11%, N 43.29%, O 16.48%
Literature References: Imidazotetrazine alkylating agent. Prepn: E. Lunt et al., DE 3231255 (1983 to May & Baker); eidem, US 5260921 (1993 to Cancer Res. Campaign Technol.); M. F. G. Stevens et al., J. Med. Chem. 27, 196 (1984). Crystal structure and structure-activity study: P. R. Lowe et al., ibid. 35, 3377 (1992). Synthesis: Y. Wang et al., J. Org. Chem. 62, 7288 (1997). HPLC determn in plasma and urine: F. Shen et al., J. Chromatogr. B 667, 291 (1995). Review of pharmacology and clinical efficacy in melanoma and brain tumor: E. S. Newlands et al., Cancer Treat. Rev. 23, 35-61 (1997); S. J. Danson, M. R. Middleton, Expert Rev. Anticancer Ther. 1, 13-19 (2001).
Properties: Crystals from dichloromethane, mp 212° (dec). uv max (95% ethanol): 327 nm.
Melting point: mp 212° (dec)
Absorption maximum: uv max (95% ethanol): 327 nm
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Alkylating Agents.