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CAS No 86386-73-4 , 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol

  • Name: 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol
  • Synonyms: Biocanol; Triflucan; Flucostat; Biozolene;2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol;Diflucan; Flukezol; Elazor; Flunizol; Flucazol;
  • CAS Registry Number:
  • Melting Point: 138-140 ºC
  • Flash Point: 304.4 ºC
  • Boiling Point: 579.8 ºC at 760 mmHg
  • Density: 1.49 g/cm3
  • Water Solubility: DMSO: 5 mg/mL
  • Safety Statements: 26-36/37/39-24/25
  • Hazard Symbols: Xn: Harmful;
  • Flash Point: 304.4 ºC
  • Molecular Weight: 306.270786
  • InchiKey: RFHAOTPXVQNOHP-UHFFFAOYSA-N
  • InChI: InChI=1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,
    4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2
  • Risk Statements: 36/37/38-20/21/22
  • Molecular Formula: C13H12F2N6O
  • Molecular Structure:CAS No:86386-73-4 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol

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References of 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol
Title: Fluconazole
CAS Registry Number: 86386-73-4
CAS Name: a-(2,4-Difluorophenyl)-a-(1H-1,2,4-triazol-1-ylmethyl)-1H-1,2,4-triazole-1-ethanol
Synonyms: 2,4-difluoro-a,a-bis(1H-1,2,4-triazol-1-ylmethyl)benzyl alcohol; 2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol
Manufacturers' Codes: UK-49858
Trademarks: Biozolene (Bioindustria); Diflucan (Pfizer); Elazor (Sigma-Tau); Triflucan (Pfizer)
Molecular Formula: C13H12F2N6O
Molecular Weight: 306.27
Percent Composition: C 50.98%, H 3.95%, F 12.41%, N 27.44%, O 5.22%
Literature References: Orally active bistriazole antifungal agent. Prepn: K. Richardson, GB 2099818; idem, US 4404216 (1982, 1983 both to Pfizer). Antifungal activity in vivo: K. Richardson et al., Antimicrob. Agents Chemother. 27, 832 (1985); and in vitro: T. E. Rogers, J. N. Galgiani, ibid. 30, 418 (1986). Pharmacokinetics: M. J. Humphrey et al., ibid. 28, 648 (1985). GC determn in human plasma and urine: P. R. Wood, M. H. Tarbit, J. Chromatogr. 383, 179 (1986). Evaluation as maintenance therapy for cryptococcal meningitis in AIDS patients: S. A. Bozzette et al., N. Engl. J. Med. 324, 580 (1991). Symposium on mode of action, toxicology, animal models and clinical studies: International Telesymposium on Recent Trends in the Discovery, Development and Evaluation of Antifungal Agents Section 2, R. A. Fromtling, Ed. (J. R. Prous Science Publ., Barcelona, 1987) pp 77-174. Infection prophylaxis in bone marrow transplantation patients: M. L. MacMillan et al., Am. J. Med. 112, 369 (2002).
Properties: Crystals from ethyl acetate/hexane, mp 138-140°.
Melting point: mp 138-140°
 
Derivative Type: Dihydrogen phosphate ester
CAS Registry Number: 194798-83-9
Synonyms: Fosfluconazole; 2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propyl dihydrogen phosphate
Trademarks: Prodif (Pfizer)
Molecular Formula: C13H13F2N6O4P
Molecular Weight: 386.25
Percent Composition: C 40.42%, H 3.39%, F 9.84%, N 21.76%, O 16.57%, P 8.02%
Literature References: Prepn: C. W. Murtiashaw et al., WO 9728169; S. Green et al., US 6790957 (1997, 2004 both to Pfizer). Review of discovery and commercial process development: A. Bentley et al., Org. Process Res. Dev. 6, 109-112 (2002).
Properties: Water-soluble prodrug. White powder, mp 223-224°.
Melting point: mp 223-224°
 
Therap-Cat: Antifungal.
Keywords: Antifungal (Synthetic); Triazoles.