Home > Name List By other > (2S,3aS, 6aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl] -3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]py...

CAS No 87333-19-5 , (2S,3aS,
6aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]
-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole-2-carboxylic acid

  • Name: (2S,3aS,
    6aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]
    -3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole-2-carboxylic acid
  • Synonyms: Acovil; Vesdil; Delix; Carasel;Tritace; Altace;(2S,3aS,
    6aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]
    -3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole-2-carboxylic acid; Triatec; Ramace; Cardace;
  • CAS Registry Number:
  • Density: 1.2 g/cm3
  • Safety Statements: S26;S37/39;
  • Hazard Symbols: Xi
  • Molecular Weight: 416.51058
  • InchiKey: HDACQVRGBOVJII-JBDAPHQKSA-N
  • InChI: InChI=1S/C23H32N2O5/c1-3-30-23(29)18(13-12-16-8-5-4-6-9-16)24-15(2)21
    (26)25-19-11-7-10-17(19)14-20(25)22(27)28/h4-6,8-9,15,17-20,24H,3,7,
    10-14H2,1-2H3,(H,27,28)/t15-,17-,18-,19-,20-/m0/s1
  • Risk Statements: 36/38
  • Molecular Formula: C23H32N2O5
  • Molecular Structure:CAS No:87333-19-5 (2S,3aS,<br />6aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]<br />-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole-2-carboxylic acid

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References of (2S,3aS,
6aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]
-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole-2-carboxylic acid
Title: Ramipril
CAS Registry Number: 87333-19-5
CAS Name: [2S,3aS,6aS]-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid
Synonyms: N-(1S-carboethoxy-3-phenylpropyl)-S-alanyl-cis,endo-2-azabicyclo[3.3.0]octane-3S-carboxylic acid; (2S,3aS,6aS)-1-[(S)-N-[(S)-1-carboxy-3-phenylpropyl]alanyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid 1-ethyl ester
Manufacturers' Codes: HOE-498
Trademarks: Altace (Aventis); Cardace (Aventis); Delix (Aventis); Pramace (AstraZeneca); Quark (Polifarma); Ramace (AstraZeneca); Triatec (Aventis); Tritace (Aventis); Unipril (Zambon); Vesdil (AstraZeneca)
Molecular Formula: C23H32N2O5
Molecular Weight: 416.51
Percent Composition: C 66.32%, H 7.74%, N 6.73%, O 19.21%
Literature References: Angiotensin converting enzyme (ACE) inhibitor; converted to active, diacid metabolite, ramiprilat. Prepn: V. Teetz et al, EP 79022 (1983 to Hoechst A.G.), C.A. 100, 52012h (1984); E. H. Gold et al., US 4587258 (1986 to Schering Corp.); V. Teetz et al., Arzneim.-Forsch. 34, 1399 (1984). Radioimmunoassay determn in human serum and plasma: H. G. Eckert et al., ibid. 35, 1251 (1985). Toxicology: H. H. Donaubauer, D. Mayer, ibid. 38, 14 (1988). Symposium on pharmacology and clinical efficacy: Am. J. Cardiol. 59, 1D-177D (1987). Clinical trial in chronic nephropathy: P. Ruggenenti et al., Lancet 352, 1252 (1998). Clinical prevention of cardiovascular events in high-risk patients: HOPE Study Investigators, N. Engl. J. Med. 342, 145 (2000). Clinical trial in prevention of stroke: J. Bosch et al., Br. Med. J. 324, 1 (2002).
Properties: Felty needles from ether, mp 109°. [a]D24 +33.2° (c = 1 in 0.1N ethanolic HCl). LD50 (14 day) in male, female mice, male, female rats (mg/kg): 1194, 1158, 687, 608 i.v.; 10933, 10048, >10000, >10000 orally (Donaubauer, Mayer).
Melting point: mp 109°
Optical Rotation: [a]D24 +33.2° (c = 1 in 0.1N ethanolic HCl)
Toxicity data: LD50 (14 day) in male, female mice, male, female rats (mg/kg): 1194, 1158, 687, 608 i.v.; 10933, 10048, >10000, >10000 orally (Donaubauer, Mayer)
Therap-Cat: Antihypertensive.
Keywords: ACE-Inhibitor; Antihypertensive; N-Carboxyalkyl (peptide/lactam) Derivatives.