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CAS No 89-57-6 , 5-amino-2-hydroxybenzoic acid

  • Name: 5-amino-2-hydroxybenzoic acid
  • Synonyms: Mesalazine; mesalamine; Canasa; Pentasa;5-amino-2-hydroxybenzoic acid; 5-Amino-2-hydroxybenzoic acid;5-Aminosalicylic acid; Asacol; Salofalk; Claversal; Rowasa;
  • CAS Registry Number:
  • Melting Point: 280 ºC
  • Flash Point: 403.9ºC at 760 mmHg
  • Boiling Point: 403.9ºC at 760 mmHg
  • Density: 1.491 g/cm3
  • Water Solubility: <0.1 G/100 ML AT 21 ºC
  • Safety Statements: S24/25
  • Hazard Symbols: Xi
  • HS Code: 29225000
  • Flash Point: 403.9ºC at 760 mmHg
  • EINECS: 201-919-1
  • Molecular Weight: 153.13538
  • InchiKey: KBOPZPXVLCULAV-UHFFFAOYSA-N
  • InChI: InChI=1S/C7H7NO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9H,8H2,(H,10,11)
  • Risk Statements: S24/25
  • Molecular Formula: C7H7NO3
  • Molecular Structure:CAS No:89-57-6 5-amino-2-hydroxybenzoic acid

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89-57-6 5-AMINOSALICYLIC ACID USP

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89-57-6 Mesalazine

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89-57-6 5-Aminosalicylic acid

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89-57-6 5-Aminosalicylic acid

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89-57-6 Mesalazine

  • Mesalazine, 99,5%
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89-57-6 5-Amino salicylic Acid

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89-57-6 MESALAMINE

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References of 5-amino-2-hydroxybenzoic acid
Title: Mesalamine
CAS Registry Number: 89-57-6
CAS Name: 5-Amino-2-hydroxybenzoic acid
Synonyms: 5-aminosalicylic acid; 5-amino-2-hydroxybenzene-1-carboxylic acid; m-aminosalicylic acid; fisalamine; mesalazine; 5-ASA
Trademarks: Asacol (Tillotts); Asacolitin (Tillotts); Claversal (Merckle); Lixacol (Schering-Plough); Mesasal (Sanofi-Synthelabo); Pentasa (Ferring); Rowasa (Solvay); Salofalk (Falk)
Molecular Formula: C7H7NO3
Molecular Weight: 153.14
Percent Composition: C 54.90%, H 4.61%, N 9.15%, O 31.34%
Literature References: Prepn by reduction of m-nitrobenzoic acid with Zn dust and HCl: H. Weil et al., Ber. 55B, 2664 (1922); by electrolytic reduction: Le Guyader, Peltier, Compt. Rend. 253, 2544 (1961). Use in manufacture of dyes: GB 751386 (1956 to J. R. Geigy). Identification as active metabolite of sulfasalazine, q.v.: A. K. Azad Khan et al., Lancet 2, 892 (1977); P. A. M. Van Hees et al., Gut 21, 632 (1980). HPLC determn in serum: E. Brendel et al., J. Chromatogr. 385, 299 (1987). Bioavailability, plasma level and excretion: S. N. Rasmussen et al., Gastroenterology 83, 1062 (1982). Clinical evaluation in Crohn's disease: eidem, ibid. 85, 1350 (1983). Clinical trials in ulcerative colitis: M. Campieri et al., Lancet 2, 270 (1981); L. S. Friedman et al., Am. J. Gastroenterol. 81, 412 (1986); in comparison with olsalazine, q.v.: S. S. Rao et al., Scand. J. Gastroenterol. 22, 332 (1987). Brief review: G. Friedman, Am. J. Gastroenterol. 81, 141-144 (1986). Review of clinical efficacy in colonic diverticulosis: A. Tursi, Expert Opin. Pharmacother. 6, 69-74 (2005).
Properties: White to pinkish crystals, dec ~280°. Slightly sol in cold water, alc; more sol in hot water; sol in HCl.
Use: In manuf of light-sensitive paper, azo and sulfur dyes.
Therap-Cat: Anti-inflammatory (gastrointestinal).
Keywords: Anti-inflammatory (Gastrointestinal); Anti-inflammatory (Nonsteroidal); Salicylic Acid Derivatives.