Home > Name List By other > (4S)-3-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl] -1-methyl-2-oxoimidazolidine-4-carboxylic acid

CAS No 89371-37-9 , (4S)-3-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]
-1-methyl-2-oxoimidazolidine-4-carboxylic acid

  • Name: (4S)-3-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]
    -1-methyl-2-oxoimidazolidine-4-carboxylic acid
  • Synonyms: Imidaprilum [INN-Latin]; (S)-3-(N-((S)-1-Ethoxycarbonyl-3-phenylpropyl)-L-alanyl)-1-methyl-2-oxoimidazoline-4-carboxylic acid; 89371-37-9;(4S)-3-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]
    -1-methyl-2-oxoimidazolidine-4-carboxylic acid;
  • CAS Registry Number:
  • Melting Point: 195-197ºC
  • Flash Point: 302.8ºC
  • Boiling Point: 577ºC at 760 mmHg
  • Density: 1.266 g/cm3
  • Flash Point: 302.8ºC
  • Molecular Weight: 405.44488
  • InchiKey: KLZWOWYOHUKJIG-BPUTZDHNSA-N
  • InChI: InChI=1S/C20H27N3O6/c1-4-29-19(27)15(11-10-14-8-6-5-7-9-14)21-13(2)17
    (24)23-16(18(25)26)12-22(3)20(23)28/h5-9,13,15-16,21H,4,10-12H2,1-3H3,
    (H,25,26)/t13-,15-,16-/m0/s1
  • Molecular Formula: C20H27N3O6
  • Molecular Structure:CAS No:89371-37-9 (4S)-3-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]<br />-1-methyl-2-oxoimidazolidine-4-carboxylic acid

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References of (4S)-3-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]
-1-methyl-2-oxoimidazolidine-4-carboxylic acid
Title: Imidapril
CAS Registry Number: 89371-37-9
CAS Name: (4S)-3-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-4-imidazolidinecarboxylic acid
Synonyms: (4S)-3-[(2S)-2-[N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]propionyl]-1-methyl-2-oxoimidazolidine-4-carboxylic acid
Molecular Formula: C20H27N3O6
Molecular Weight: 405.44
Percent Composition: C 59.25%, H 6.71%, N 10.36%, O 23.68%
Literature References: Angiotensin converting enzyme (ACE) inhibitor. Prepn: N. Yoneda et al., EP 95163; eidem, US 4508727 (1983, 1985 both to Tanabe Seiyaku); K. Hayashi et al., J. Med. Chem. 32, 289 (1989). Series of articles on pharmacology, pharmacokinetics and metabolism in animals: Arzneim.-Forsch. 42, 446-512 (1992). HPLC determn in plasma and urine: K. Tagawa et al., J. Chromatogr. 617, 95 (1993). Clinical pharmacology: P. Démolis et al., Fundam. Clin. Pharmacol. 8, 80 (1994). Clinical trial in hypertension: M. J. Vandenburg et al., Br. J. Clin. Pharmacol. 37, 265 (1994).
Properties: Colorless crystals from ethyl acetate + n-hexane, mp 139-140°. [a]D20 -71.7° (c = 0.5 in ethanol).
Melting point: mp 139-140°
Optical Rotation: [a]D20 -71.7° (c = 0.5 in ethanol)
 
Derivative Type: Monohydrochloride
CAS Registry Number: 89396-94-1
Manufacturers' Codes: TA-6366
Trademarks: Novaloc (Schering AG); Tanatril (Tanabe)
Molecular Formula: C20H27N3O6.HCl
Molecular Weight: 441.91
Percent Composition: C 54.36%, H 6.39%, N 9.51%, O 21.72%, Cl 8.02%
Properties: Colorless crystals, mp 214-216° (dec). [a]D20 -64.1° (c = 0.5 in ethanol).
Melting point: mp 214-216° (dec)
Optical Rotation: [a]D20 -64.1° (c = 0.5 in ethanol)
 
Derivative Type: Diacid
CAS Registry Number: 89371-44-8
Synonyms: Imidaprilat
Molecular Formula: C18H23N3O6
Molecular Weight: 377.39
Percent Composition: C 57.29%, H 6.14%, N 11.13%, O 25.44%
Properties: Crystals, mp 239-241° (dec). [a]D19 -88.4° (c = 1 in 5% NaHCO3).
Melting point: mp 239-241° (dec)
Optical Rotation: [a]D19 -88.4° (c = 1 in 5% NaHCO3)
 
Therap-Cat: Antihypertensive.
Keywords: ACE-Inhibitor; Antihypertensive; N-Carboxyalkyl (peptide/lactam) Derivatives.