Title: Hetastarch
CAS Registry Number: 9004-62-0
CAS Name: Starch 2-hydroxyethyl ether
Synonyms: hydroxyethyl starch; HES
Trademarks: 6-H.E.S. (Morishita); Hespan (BMS); Hespander (Kyorin); Hestar (Pisa); Plasmasteril (Fresenius)
Literature References: A starch derivative of undetermined exact composition. Comprised of more than 90% amylopectin and etherified to the extent that an average of 7 to 8 of the OH groups present in every ten D-glucopyranose units of the polymer have been converted to OCH2CH2OH groups. Preparation by treating starch with pyridine and ethylene chlorohydrin: Mima, Yokoyama,
JP 70 6556 (1970 to Green Cross),
C.A. 73, 36822r (1970). Structure evaluation studies: Banks
et al., Br. J. Pharmacol. 47, 172 (1973). Physicochemical and biological properties: Tamada
et al., Chem. Pharm. Bull. 19, 286 (1971); Banks
et al., Staerke 24, 181 (1972). Pharmacology: Irikura
et al., Oyo Yakuri 6, 985 sqq (1972). Metabolism: Bogan
et al., Toxicol. Appl. Pharmacol. 15, 206 (1969); Ryan
et al., Xenobiotica 2, 141 (1972). Toxicity studies: Irikura
et al., Oyo Yakuri 6, 1023 (1972). Introduction as a plasma expander: Wiedersheim,
Arch. Int. Pharmacodyn. 111, 353 (1957). Review of production and uses: Hjermstad,
Starch Chem. Technol. 2, 423-432 (1967).
Properties: White powder. Very sol in water. Insol in alcohol.
Derivative Type: Amylopectin derivative
Properties: The sequence is frequently interrupted by a unit in which R￠ is the residue of an additional
O-hydroxyethylated a-D-glucopyranosyl moiety that constitutes the first unit in a branch or sub-branch of the polymer.
Use: Cryoprotective agent for erythrocytes.
Therap-Cat: Plasma volume expander.
Therap-Cat-Vet: Plasma volume expander.
Keywords: Plasma Volume Expander.
