Title: Iron Dextran
CAS Registry Number: 9004-66-4
Synonyms: Dextran iron complex
Trademarks: DexFerrum (American Regent); Imferon (Fisons); INFeD (Watson)
Literature References: Complex of ferric hydroxide with dextran,
q.q.v. Prepn: E. London, G. D. Twigg,
US 2820740 (1958 to Benger);
US RE 24642 (1959); J. R. Herb,
US 2885393 (1959 to Laros). Use in treatment of iron-deficiency anemia: I. M. Baird, D. A. Podmore,
Lancet 264, 942 (1954). Acute toxicity: R. P. Beliles,
Toxicol. Appl. Pharmacol. 23, 537 (1972). Comparison of different formulations: R. Lawrence,
PDA J. Pharm. Sci. Technol. 52, 190 (1998). M?ssbauer spectroscopy and x-ray diffraction study: B. Knight
et al., J. Inorg. Biochem. 73, 227 (1999). Use as an iron supplement for anemic piglets: A. K. Egeli, T. Framstad,
Res. Vet. Sci. 66, 179 (1999). Clinical evaluation in iron deficiency: J. C. Barton
et al., Am. J. Med. 109, 27 (2000). Review of carcinogenicity studies:
IARC Monographs 2, 161-178 (1973); of clinical experience: D. L. Burns
et al., Nutrition 11, 163-168 (1995); of toxicity profile: D. L. Burns, J. J. Pomposelli,
Kidney Int. 55, S119-S124 (1999).
Properties: Commercial product is a dark brown, slightly viscous soln. Very sol in water, DMSO. Dec in 95% ethanol and acetone. LD50 i.v. in mice: 2240 mg Fe/kg (Beliles).
Toxicity data: LD50 i.v. in mice: 2240 mg Fe/kg (Beliles)
CAUTION: This substance is reasonably anticipated to be a human carcinogen:
Report on Carcinogens, Eleventh Edition (PB2005-104914, 2004) p III-155.
Therap-Cat: Hematinic.
Therap-Cat-Vet: Nutritional factor (parenteral). Used in iron deficiency anemia, chiefly in pigs.
Keywords: Hematinic.
