Home > Name List By 5 > 5-methyl-6,6-dioxo-3-pyridin-2-yl-[1,3]oxazino[5,6-c][1, 2]benzothiazine-2,4-dione Germany

CAS No 90101-16-9 , 5-methyl-6,6-dioxo-3-pyridin-2-yl-[1,3]oxazino[5,6-c][1,
2]benzothiazine-2,4-dione Search by region : Germany

  • Name: 5-methyl-6,6-dioxo-3-pyridin-2-yl-[1,3]oxazino[5,6-c][1,
    2]benzothiazine-2,4-dione
  • Synonyms: E 318; BRN 6006252; Droxicam [INN];Droxicamum [Latin]; 90101-16-9; E-3128;5-methyl-6,6-dioxo-3-pyridin-2-yl-[1,3]oxazino[5,6-c][1,
    2]benzothiazine-2,4-dione; Droxicam (INN);
  • CAS Registry Number:
  • Flash Point: 289.3°C
  • Boiling Point: 554.7°Cat760mmHg
  • Density: 1.68g/cm3
  • Refractive index: 1.747
  • Flash Point: 289.3°C
  • Molecular Weight: 357.34064
  • InchiKey: OEHFRZLKGRKFAS-UHFFFAOYSA-N
  • InChI: InChI=1S/C16H11N3O5S/c1-18-13-14(10-6-2-3-7-11(10)25(18,
    22)23)24-16(21)19(15(13)20)12-8-4-5-9-17-12/h2-9H,1H3
  • Molecular Formula: C16H11N3O5S
  • Molecular Structure:CAS No:90101-16-9 5-methyl-6,6-dioxo-3-pyridin-2-yl-[1,3]oxazino[5,6-c][1,<br />2]benzothiazine-2,4-dione

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References of 5-methyl-6,6-dioxo-3-pyridin-2-yl-[1,3]oxazino[5,6-c][1,
2]benzothiazine-2,4-dione
Title: Droxicam
CAS Registry Number: 90101-16-9
CAS Name: 5-Methyl-3-(2-pyridinyl)-2H,5H-1,3-oxazino[5,6-c][1,2]benzothiazine-2,4(3H)-dione 6,6-dioxide
Manufacturers' Codes: E-3128
Trademarks: Dobenam (Angelini); Droxar (Upjohn); Ombolan (Esteve)
Molecular Formula: C16H11N3O5S
Molecular Weight: 357.34
Percent Composition: C 53.78%, H 3.10%, N 11.76%, O 22.39%, S 8.97%
Literature References: Prodrug of piroxicam. Prepn: J. E. Soler, FR 2528433; idem, US 4563452 (1983, 1986 both to Provesan SA). Spectroscopic structural analysis: J. Frigola, J. Chem. Soc. Perkin Trans. 2 1988, 241. Pharmacology: A. J. Farré et al., Methods Find. Exp. Clin. Pharmacol. 8, 407 (1986). Metabolism and pharmacokinetics in animals: A. Esteve et al., ibid. 423. Inhibition of platelet aggregation: J. Esteve et al., ibid. 9, 209 (1987). Evaluation of ulcerogenic effects in comparison with piroxicam: G. Palacios et al., ibid. 353. Clinical pharmacology: L. Martinez et al., ibid. 10, 729 (1988). Brief review of pharmacology: J. Esteve et al., Gen. Pharmacol. 19, 49-54 (1988).
Properties: Crystals from acetone. mp 259-261°. LD50 orally in male, female mice, and male, female rats: 6192, 8841, 1434, 1994 mg/kg (Soler, 1986).
Melting point: mp 259-261°
Toxicity data: LD50 orally in male, female mice, and male, female rats: 6192, 8841, 1434, 1994 mg/kg (Soler, 1986)
Therap-Cat: Anti-inflammatory.
Keywords: Anti-inflammatory (Nonsteroidal); Thiazinecarboxamides.
 
 
Status: This monograph has been retired and is no longer subject to revision or update.