Title: Batroxobin
CAS Registry Number: 9039-61-6
CAS Name: Bothrops atrox serine proteinase
Synonyms: Bothrops venom proteinase
Trademarks: Botropase (Ravizza); Defibrase (Gerot)
Literature References: Thrombin-like enzyme from the venom of
Bothrops atrox (Linn.), a pit viper found in several varieties in Southern and Central America. Prepn of conc extract from
B. jararaca venom and coagulative properties: D. von Klobusitzky,
Arch. Exp. Pathol. Pharmakol. 179, 204 (1935). The enzyme from
B. atrox venom is hemostatic at low doses and acts as a blood anti-coagulant at higher doses. Composition and manuf: E. E. Percs
et al., DE 2201993;
eidem, US 3849252 (1972, 1974 both to Pentapharm). Studies on the subunit structure of fibrin produced by batroxobin: P. Mattock, M. P. Esnouf,
Nature New Biol. 233, 277 (1971).
In vitro blood-clotting activity: K. O. Wik
et al., Br. J. Haematol. 23, 37 (1972). Electron microscopic study: S. Ishimaru
et al., Thromb. Haemostasis 45, 276 (1981). Clinical pharmacology: K. Fukutake
et al., Nippon Ketsueki Gakkai Zasshi 44, 1178 (1981),
C.A. 96, 62775x (1982). Review of characterization, properties: K. G. Stocker, G. H. Barlow,
Aktuel. Probl. Angiol. 26, 45-62 (1975).
Properties: Rectangular crystals. Sol in physiological saline. Practically insol in distilled water. Forms complexes with phenol and phenol derivs that are practically insol in water.
Derivative Type: Mixture with factor-X activator
Synonyms: Hemocoagulase
Trademarks: Reptilase (Knoll)
Therap-Cat: Hemostatic.
Keywords: Hemostatic.
