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CAS No 9041-93-4 , Bleomycin sulfate Search by region : India

  • Name: Bleomycin sulfate
  • Synonyms: 3-[[2-[2-[2-[2-[4-[2-[6-Amino-2-[1-(2-amino-2-carbamoyl-ethyl)amino-2-carbamoyl-ethyl]-5-methyl-pyrimidin-4-yl]carbonylamino-3-[3-[4-carbamoyloxy-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-3-(3H-imidazol-4-yl)propanoyl]amino-3-hydroxy-2-methyl-pentanoyl]amino-3-hydroxy-butanoyl]aminoethyl]-1,3-thiazol-4-yl]-1,3-thiazol-4-yl]carbonylamino]propyl-dimethyl-sulfonium hydrogen sulfate;bleomycin sulfate from streptomyces verticillus;Bleomycin sulfate;
  • CAS Registry Number:
  • Melting Point: 197 deg C (dec)
  • Water Solubility: 20 mg/mL in water
  • Safety Statements: 53-36/37-45-36-26
  • Hazard Symbols: T: Toxic;Xi: Irritant;
  • EINECS: 232-925-2
  • Molecular Weight: 1512.62
  • InChI: InChI=1/C55H83N17O21S3.H2O4S/c1-20-33(69-46(72-44(20)58)25(12-31(57)76)64-13-24(56)45(59)82)50(86)71-35(41(26-14-61-19-65-26)91-54-43(39(80)37(78)29(15-73)90-54)92-53-40(81)42(93-55(60)88)38(79)30(16-74)89-53)51(87)66-22(3)36(77)21(2)47(83)70-34(23(4)75)49(85)63-10-8-32-67-28(18-94-32)52-68-27(17-95-52)48(84)62-9-7-11-96(5)6;1-5(2,3)4/h14,17-19,21-25,29-30,34-43,53-54,64,73-75,77-81H,7-13,15-16,56H2,1-6H3,(H13-,57,58,59,60,61,62,63,65,66,69,70,71,72,76,82,83,84,85,86,87,88);(H2,1,2,3,4)/t21?,22?,23?,24?,25?,29-,30+,34?,35?,36?,37+,38+,39-,40-,41?,42-,43-,53+,54-;/m0./s1
  • Risk Statements: 46-40-36/37/38
  • Molecular Formula: C55H84N17O21S3.HSO4
  • Molecular Structure:CAS No:9041-93-4 Bleomycin sulfate

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9041-93-4 Bleomycin Sulfate

  • India Manus Aktteva null
  • Tel: +91-(79)-65123395
  • Fax: +91-(79)-26463395
  • Address: 303, 3rd Floor, Royale Manor, Law Garden, Dhulia Kot Road, Ellisbridge, Ahmedabad, Gujarat 380006, null,nullIndia
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9041-93-4 Bleomycin Sulphate

  • Bleomycin Sulphate
  • India J.INC. [Manufacturer]
  • Tel: +91 79 30071152, 30071190, 30071175, 30071153
  • Fax: +91 79 30071176, 26574630
  • Address: # 95, Rangwala Towers, Law garden, Ellisbridge, Ahmedabad 380006, Gujarat State, India. 380006 AhmedabadINDIA Ahmedabad,nullIndia
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References of Bleomycin sulfate
Title: Bleomycins
Manufacturers' Codes: NSC-125066
Literature References: A group of related glycopeptide antibiotics. Variations in the terminal amine account for differing activities. Isolated from Streptomyces verticillus: Umezawa, Antimicrob. Agents Chemother. 1965, 1079. Purification and separation into bleomycins A and B and their components: Umezawa et al., J. Antibiot. 19, 200, 210 (1966); T. Takita et al., ibid. 21, 79 (1968); 22, 237 (1969). Bleomycin A2 is the main component of the bleomycin employed clinically. Total structure elucidation: T. Takita et al., ibid. 25, 755 (1972). Revised structure: eidem, ibid. 31, 801 (1978). Terminal amines: Fujii et al., ibid. 26, 398 (1973). Synthesis of new bleomycins: T. Takita et al., ibid. 254. Total synthesis of bleomycin A2: eidem, Tetrahedron Lett. 23, 521 (1982). Improved total synthesis: S. Saito et al., J. Antibiot. 36, 92 (1983). Biosynthesis: Fujii et al., ibid. 27, 73 (1974). Bleomycins are believed to react with DNA and cause strand scission; they have also been shown to have a type of oxygen transferase activity. Mechanism of action studies: R. M. Burger et al., Life Sci. 28, 715 (1981); N. Marugesan et al., J. Biol. Chem. 257, 8600 (1982). Coordination chemistry: J. C. Dabrowiak, J. Inorg. Biochem. 13, 317 (1980). Clinical pharmacology: S. T. Crooke, Cancer Chemother. 3, 343 (1981). Characterization of analogs: N. J. Oppenheimer et al., J. Biol. Chem. 257, 1606 (1982). Reviews: H. Umezawa, Pure Appl. Chem. 28, 665-680 (1971); C. W. Haidle, R. S. Lloyd, Antibiotics vol. 5(pt. 2), F. E. Hahn, Ed. (Springer-Verlag, New York, 1979) pp 124-154; H. Umezawa, Anticancer Agents Based on Natural Product Models, J. M. Cassady, J. D. Douros, Eds. (Academic Press, New York, 1980) pp 147-166.
Properties: Colorless or yellowish powder which becomes bluish depending on Cu content. Very sol in water, methanol; slightly sol in ethanol. Practically insol in acetone, ethyl acetate, butyl acetate, ether. uv max: 244-248, 289-294 nm (E1%1cm 121-148, 102-121.5).
Absorption maximum: uv max: 244-248, 289-294 nm (E1%1cm 121-148, 102-121.5)
 
Derivative Type: Sulfate
CAS Registry Number: 9041-93-4
Trademarks: Blenoxane (BMS); Bleo (Nippon Kayaku)
 
Derivative Type: Bleomycin A2
CAS Registry Number: 11116-31-7
Synonyms: N1-[3-(Dimethylsulfonio)propyl]bleomycinamide
Molecular Formula: C55H84N17O21S3
Molecular Weight: 1415.55
Percent Composition: C 46.67%, H 5.98%, N 16.82%, O 23.74%, S 6.80%
 
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Antibiotics and Analogs.