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CAS No 911-45-5 , Clomifene Search by region : India

  • Name: Clomifene
  • Synonyms: 2-(4-[2-Chloro-1,2-diphenylethenyl]phenoxy)-N,N-diethylethanamine;Clomifene;
  • CAS Registry Number:
  • Flash Point: 261.6°C
  • Boiling Point: 509°Cat760mmHg
  • Density: 1.104g/cm3
  • Refractive index: 1.588
  • Safety Statements: Poison by intraperitoneal route. Moderately toxic by ingestion. Experimental teratogenic data. Human systemic effects by ingestion: dermatitis. Human reproductive effects by unspecified routes: death of fetus, stillbirth, and poor viability. Human teratogenic effects by unspecified routes include developmental abnormalities of the central nervous system, cardiovascular system, gastrointestinal system, and urogenital system. Other experimental teratogenic and reproductive effects. Questionable human carcinogen producing spinal cord and skin tumors. When heated to decomposition it emits very toxic fumes of Cl− and NOx.
  • Flash Point: 261.6°C
  • EINECS: 213-008-6
  • Molecular Weight: 405.96
  • InChI: InChI=1/C26H28ClNO/c1-3-28(4-2)19-20-29-24-17-15-22(16-18-24)25(21-11-7-5-8-12-21)26(27)23-13-9-6-10-14-23/h5-18H,3-4,19-20H2,1-2H3/b26-25-
  • Molecular Formula: C26H28ClNO
  • Molecular Structure:CAS No:911-45-5 Clomifene

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911-45-5 Clomifene

  • IUPAC NAME-(E,Z)-2-(4-(2-chloro-1,2-diphenylethenyl) phenoxy)-N,N-diethyl-ethanamine MOLECULAR FORMULA-C26H28ClNO MOLAR MASS-406 or 598.10 (with citrate) It is used mainly in female infertility, in turn mainly as ovulation induction to reverse oligoo...
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References of Clomifene
Title: Clomiphene
CAS Registry Number: 911-45-5
CAS Name: 2-[4-(2-Chloro-1,2-diphenylethenyl)phenoxy]-N,N-diethylethanamine
Synonyms: 2-[p-(2-chloro-1,2-diphenylvinyl)phenoxy]triethylamine; 2-[p-(b-chloro-a-phenylstyryl)phenoxy]triethylamine; 1-[p-(b-diethylaminoethoxy)phenyl]-1,2-diphenylchloroethylene; clomifene; chloramiphene
Manufacturers' Codes: MRL-41; WSM-5008
Molecular Formula: C26H28ClNO
Molecular Weight: 405.96
Percent Composition: C 76.92%, H 6.95%, Cl 8.73%, N 3.45%, O 3.94%
Literature References: Synthetic estrogen agonist-antagonist. Prepn: R. E. Allen et al., US 2914563 (1959 to Merrell); F. P. Palopoli et al., J. Med. Chem. 10, 84 (1967). Stereochemistry of the geometric isomers: Ernst et al., J. Pharm. Sci. 65, 148 (1976). Induction of ovulation: R. B. Greenblatt, Fertil. Steril. 12, 402 (1961). Clinical trial in anovulatory women: J. Garcia et al., ibid. 28, 707 (1977). Use in male infertility: P. J. Sorbie, R. Perez-Marrero, J. Urol. 131, 425 (1984). HPLC determn of isomers in human plasma: C. L. Baustian, T. J. Mikkelson, J. Pharm. Biomed. Anal. 4, 237 (1986). Review of development, pharmacology and clinical experience: R. P. Dickey, D. E. Holtkamp, Hum. Reprod. Update 2, 483-506 (1996).
 
Derivative Type: Citrate
CAS Registry Number: 50-41-9
Trademarks: Clomid (Aventis); Clostilbegyt (Egis); Pergotime (Serono); Serofene (Serono); Serophene (Serono)
Molecular Formula: C26H28ClNO.C6H8O7
Molecular Weight: 598.08
Percent Composition: C 64.26%, H 6.07%, Cl 5.93%, N 2.34%, O 21.40%
Properties: Crystals, mp 116.5-118°. Slightly sol in water, chloroform; freely sol in methanol; sparingly sol in alcohol. Insol in ether.
Melting point: mp 116.5-118°
 
Derivative Type: cis-Form
CAS Registry Number: 15690-55-8
Synonyms: Zuclomiphene
Properties: Hydrochloride salt mp 156.5-158.0°. uv max (methanol): 230, 291 nm (e 20500, 12700).
Melting point: mp 156.5-158.0°
Absorption maximum: uv max (methanol): 230, 291 nm (e 20500, 12700)
 
Derivative Type: trans-Form
CAS Registry Number: 15690-57-0
Synonyms: Enclomiphene
Properties: Hydrochloride salt mp 149.0-150.5°. uv max (methanol): 239, 297 nm (e 22100, 11600).
Melting point: mp 149.0-150.5°
Absorption maximum: uv max (methanol): 239, 297 nm (e 22100, 11600)
 
Therap-Cat: Gonad-stimulating principle.
Keywords: Gonad-Stimulating Principle.