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CAS No 915-30-0 , ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylate

  • Name: ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylate
  • Synonyms: Lomotil; Difenoxilato;ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylate;Difenossilato [DCIT]; Diphenoxalate; Difenoxilato [INN-Spanish]; Diphenoxylatum [INN-Latin]; Diphenoxylatum;
  • CAS Registry Number:
  • Melting Point: 220 - 225
  • Density: 1.123 g/cm3
  • EINECS: 213-020-1
  • Molecular Weight: 452.58728
  • InchiKey: HYPPXZBJBPSRLK-UHFFFAOYSA-N
  • InChI: InChI=1S/C30H32N2O2/c1-2-34-28(33)29(25-12-6-3-7-13-25)18-21-32(22-19-
    29)23-20-30(24-31,26-14-8-4-9-15-26)27-16-10-5-11-17-27/h3-17H,2,
    18-23H2,1H3
  • Molecular Formula: C30H32N2O2
  • Molecular Structure:CAS No:915-30-0 ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylate
References of ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylate
Title: Diphenoxylate
CAS Registry Number: 915-30-0
CAS Name: 1-(3-Cyano-3,3-diphenylpropyl)-4-phenyl-4-piperidinecarboxylic acid ethyl ester
Synonyms: 1-(3-cyano-3,3-diphenylpropyl)-4-phenylisonipecotic acid ethyl ester; ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylisonipecotate; ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-4-piperidinecarboxylate; 2,2-diphenyl-4-(4-carbethoxy-4-phenylpiperidino)butyronitrile
Manufacturers' Codes: R-1132
Molecular Formula: C30H32N2O2
Molecular Weight: 452.59
Percent Composition: C 79.61%, H 7.13%, N 6.19%, O 7.07%
Literature References: Prepn: Janssen, US 2898340 (1959). Pharmacokinetics and metabolism: Karim et al., J. Pharmacol. Exp. Ther. 177, 546 (1971); Clin. Pharmacol. Ther. 13, 407 (1972). See also Difenoxin, the active metabolite of diphenoxylate. Comprehensive description: D. D. Hung, Anal. Profiles Drug Subs. 7, 149-169 (1978).
 
Derivative Type: Hydrochloride
CAS Registry Number: 3810-80-8
Molecular Formula: C30H32N2O2.HCl
Molecular Weight: 489.05
Percent Composition: C 73.68%, H 6.80%, N 5.73%, O 6.54%, Cl 7.25%
Properties: Crystals, mp 220.5-222°. uv max (methanol): 252, 258, 264 nm. Soly in mg/ml at 25°: acetic acid 500; DMF 500; chloroform 360; methanol >50; ethanol 3; water 0.8; hexane 0.5.
Melting point: mp 220.5-222°
Absorption maximum: uv max (methanol): 252, 258, 264 nm
 
Derivative Type: Mixture of hydrochloride with atropine sulfate
Trademarks: Lomotil (Searle); Diarsed (Sanofi Winthrop); Reasec (Janssen)
 
NOTE: This is a controlled substance (opiate): 21 CFR, 1308.12.
Therap-Cat: Antiperistaltic; antidiarrheal.
Keywords: Antidiarrheal.