Home > Name List By other > (6R,7R)-7-[[(2Z)-2-(2-amino-1, 3-thiazol-4-yl)-2-hydroxyiminoacetyl]amino]-3-ethenyl-8-oxo-5-thia-1- azabicyclo[4.2.0]oct-2-e... China

CAS No 91832-40-5 , (6R,7R)-7-[[(2Z)-2-(2-amino-1,
3-thiazol-4-yl)-2-hydroxyiminoacetyl]amino]-3-ethenyl-8-oxo-5-thia-1-
azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Search by region : China

  • Name: (6R,7R)-7-[[(2Z)-2-(2-amino-1,
    3-thiazol-4-yl)-2-hydroxyiminoacetyl]amino]-3-ethenyl-8-oxo-5-thia-1-
    azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • Synonyms: CI-983; Cefdinirum;Omnicef;(6R,7R)-7-[[(2Z)-2-(2-amino-1,
    3-thiazol-4-yl)-2-hydroxyiminoacetyl]amino]-3-ethenyl-8-oxo-5-thia-1-
    azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; FK-482; Cefdirnir; 91832-40-5; CFDN; Cefzon; Cefdinyl;
  • CAS Registry Number:
  • Density: 1.89 g/cm3
  • Refractive index: 1.861
  • Molecular Weight: 395.41352
  • InchiKey: RTXOFQZKPXMALH-GHXIOONMSA-N
  • InChI: InChI=1S/C14H13N5O5S2/c1-2-5-3-25-12-8(11(21)19(12)9(5)13(22)23)17-10
    (20)7(18-24)6-4-26-14(15)16-6/h2,4,8,12,24H,1,3H2,(H2,15,16)(H,17,20)(H,
    22,23)/b18-7-/t8-,12-/m1/s1
  • Molecular Formula: C14H13N5O5S2
  • Molecular Structure:CAS No:91832-40-5 (6R,7R)-7-[[(2Z)-2-(2-amino-1,<br />3-thiazol-4-yl)-2-hydroxyiminoacetyl]amino]-3-ethenyl-8-oxo-5-thia-1-<br />azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

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References of (6R,7R)-7-[[(2Z)-2-(2-amino-1,
3-thiazol-4-yl)-2-hydroxyiminoacetyl]amino]-3-ethenyl-8-oxo-5-thia-1-
azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Title: Cefdinir
CAS Registry Number: 91832-40-5
CAS Name: (6R,7R)-7-[[(2Z)-(2-Amino-4-thiazolyl)(hydroxyimino)acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Synonyms: syn-7-[2-(2-amino-4-thiazolyl)-2-hydroxyiminoacetamido]-3-vinyl-3-cephem-4-carboxylic acid
Manufacturers' Codes: FK-482; BMY-28488
Trademarks: Omnicef (Abbott)
Molecular Formula: C14H13N5O5S2
Molecular Weight: 395.41
Percent Composition: C 42.53%, H 3.31%, N 17.71%, O 20.23%, S 16.22%
Literature References: Cephalosporin antibiotic structurally similar to cefixime, q.v. Prepn: T. Takaya et al., BE 897864; eidem, US 4559334 (1984, 1985 both to Fujisawa); Y. Inamoto et al., J. Antibiot. 41, 828 (1988); H. Kamachi et al., ibid. 1602. Improved prepn: M. González et al., Farmaco 58, 409 (2003). Clinical trial in children with acute otitis media: S. L. Block et al., Pediatr. Infect. Dis. J. 23, 834 (2004). Review of pharmacokinetics and in vitro antimicrobial activity: D. R. P. Guay, ibid. 19, S141-S146 (2000); of antibacterial activity, pharmacology and clinical efficacy: C. M. Perry, L. J. Scott, Drugs 64, 1433-1464 (2004).
Properties: White to slightly brownish-yellow solid, mp 170° (dec). uv max (pH 7 phosphate buffer): 223, 286 nm (e 17400, 19700). pKa 9.70. Slightly sol in dilute HCl; sparingly sol in 0.1 M pH 7.0 phosphate buffer.
Melting point: White to slightly brownish-yellow solid, mp 170° (dec)
pKa: pKa 9.70
Absorption maximum: uv max (pH 7 phosphate buffer): 223, 286 nm (e 17400, 19700)
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); ?Lactams; Cephalosporins.