Home > Name List By 4 > 4-amino-1-[(2R,4R,5R)-3, 3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one China

CAS No 95058-81-4 , 4-amino-1-[(2R,4R,5R)-3,
3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one Search by region : China

  • Name: 4-amino-1-[(2R,4R,5R)-3,
    3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
  • Synonyms: Gemtro; Gemcitabinum [INN-Latin]; 2',2'-Difluorodeoxycytidine;dFdC; DDFC; Gemcitabina [INN-Spanish]; 95058-81-4; Gemcin;4-amino-1-[(2R,4R,5R)-3,
    3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;
  • CAS Registry Number:
  • Density: 1.84 g/cm3
  • Refractive index: 1.652
  • Safety Statements: 25-26-36/37-53
  • Hazard Symbols: Xn: Harmful;Xi: Irritant;
  • Molecular Weight: 263.198146
  • InchiKey: SDUQYLNIPVEERB-QPPQHZFASA-N
  • InChI: InChI=1S/C9H11F2N3O4/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17/
    h1-2,4,6-7,15-16H,3H2,(H2,12,13,17)/t4-,6-,7-/m1/s1
  • Risk Statements: 21-36/38-46-62-63
  • Molecular Formula: C9H11F2N3O4
  • Molecular Structure:CAS No:95058-81-4 4-amino-1-[(2R,4R,5R)-3,<br />3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

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95058-81-4 Gemcitabine

  • Gemcitabine English Synonyms: 2'-DEOXY-2',2'-DIFLUOROCYTIDINE;4-amino-1-[3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;GEMCITABINE;GEMCITABINE HCL USP;2'-Deoxy-2',2'-difluro cytidine Hydrochloride;2'-Deoxy-2',2'-difluoro-D-cytid...
  • Min. Order: 100
  • FOB Price: USD1 - 10 /
  • China Hubei Yuancheng Chemical Co.,Ltd [Manufacturer]
  • Tel: 86-27-68886667
  • Fax: 86-27-88048077
  • Address: NO866, Ziyang Road Wuhan,HubeiChina
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95058-81-4 Gemcitabine

  • Product Name: 2'-DEOXY-2',2'-DIFLUOROCYTIDINE;4-amino-1-[3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;GEMCITABINE;GEMCITABINE HCL USP;2'-Deoxy-2',2'-difluro cytidine Hydrochloride;2'-Deoxy-2',2'-difluoro-D-cytidine;2''-DEOXY-2'...
  • China Shanghai Send Pharmaceutical Technology Co., Ltd [Manufacturer]
  • Tel: 86-21-50266790
  • Fax: 86-21-50266790
  • Address: No.300 Chuantu Road Pudong District Shanghai,China Shanghai,ShanghaiChina
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95058-81-4 Gemcitabine

  • China Taiyuan RHF CO., ltd. [Manufacturers]
  • Tel: 0351-7436719
  • Fax: +86-351-7436719
  • Address: Shuangta South Alley 46,2-1, YingZe Area,Taiyuan, ShanXi null,ShanXiChina
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95058-81-4 2-Deoxy-2,2-difluoro-3,5-o-dibenzoylribose mesylate

  • 2-Deoxy-2,2-difluoro-3,5-o-dibenzoylribose mesylate, 99,00%
  • China Zeniview Chemistry Technology Co., Ltd. [Manufacturer]
  • Tel: +86-25-86088590
  • Fax: +86-25-85612276
  • Address: No.05,No.01 Hangzhongmen Dajie, Nanjing, China 210016 Nanjing CHINA 210016 NanjingCHINA Nanjing,nullChina
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95058-81-4 Gemcitabine

  • China Watson International Ltd. null
  • Tel: +86-(512)-55117610
  • Fax: +86-(512)-55117630
  • Address: Room 1209, Asia Pacific Plaza, Huaqiao International Business Park, Kunshan, Jiangsu 215332, null,nullChina
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95058-81-4 2'-Desoxy-2',2'-difluorcytidine

  • 2'-Desoxy-2',2'-difluorcytidine Gemcitabine 2,5-Dimethoxy-4-iodophenethylamine hydrochloride Gemcitabine hydrochloride Gemcitabine HCl GemcitabineHCl 2'-Deoxy-2',2'-Difluoro Cytidine(Gemcitabine) 2'-Deoxy-2',2'-difluorocytidine 2,5-Dimethoxy-4-iodoph...
  • China Suzhou Rovathin Foreign Trade Co.,Ltd [Manufacturer]
  • Tel: 86-512-65816829/ 86-512-61978430
  • Fax: 86-512-65816839
  • Address: Suzhou Rovathin Foreign Trade Co.,Ltd
    (Sales Company of Affiliated Plant in China)
    Room 603, 327 of ShiZi Street,
    Suzhou, Jiangsu, China 215006 null,nullChina
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95058-81-4 2-deoxy-2,2-difluoro-d-erythro-pentoFuranose-3,5-dibenzoate-1-methanesulfonate

  • 2-deoxy-2,2-difluoro-d-erythro-pentoFuranose-3,5-dibenzoate-1-methanesulfonate
  • China sales@credimate.com [Manufacturer]
  • Tel: +86 21 51872179
  • Fax: +86 21 51872179
  • Address: Room 2110, Tower 1, Changan Mansion, No. 1001 Changan Road200070 ShanghaiCHINA Shanghai,nullChina
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95058-81-4 Gemcitabine

  • China ORCHID CHEMICAL SUPPLIES LTD (OCS) [Importer/Exporter]
  • Tel: +86-571-85395792
  • Fax: +86-571-85420103
  • Address: 607, North Zhongshan Road, Hangzhou 310000 China null,ZhejiangChina
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95058-81-4 4-Iodo-2,5-dimethoxyphenethylamine

  • 4-Iodo-2,5-dimethoxyphenethylamine, 99%
  • China henglidahuagong co,.Ltd [Manufacturer]
  • Tel: 13996793719
  • Fax: 86+(0535?2260023
  • Address: NO 238,CANAN ROAD NORTH OF WENCANG,LAIZHOU CITY,SHANGDONG,CHINA LAIZHOU CITYCHINA LAIZHOU CITY,nullChina
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95058-81-4 Gemcitabine

  • China Ningbo Inno Pharmchem Co., Ltd. [Manufacturers]
  • Tel: +86-(574)-87319282
  • Fax: +86-(574)-56877908
  • Address: 5F, Building 4, 1035 Guangxian Rd., Ningbo Hi-Tech Park, Ningbo, Zhejiang 315040, Ningbo,ZhejiangChina
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References of 4-amino-1-[(2R,4R,5R)-3,
3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
Title: Gemcitabine
CAS Registry Number: 95058-81-4
CAS Name: 2¢-Deoxy-2¢,2¢-difluorocytidine
Synonyms: 1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose; dFdC; dFdCyd
Manufacturers' Codes: LY-188011
Trademarks: Gemzar (Lilly)
Molecular Formula: C9H11F2N3O4
Molecular Weight: 263.20
Percent Composition: C 41.07%, H 4.21%, F 14.44%, N 15.97%, O 24.32%
Literature References: Prepn: L. W. Hertel, GB 2136425; idem, US 4808614 (1984, 1989 both to Lilly); L. W. Hertel et al., J. Org. Chem. 53, 2406 (1988); T. S. Chou et al., Synthesis 1992, 565. Antitumor activity: L. W. Hertel et al., Cancer Res. 50, 4417 (1990). Mode of action study: V. W. T. Ruiz et al., Biochem. Pharmacol. 46, 762 (1993). Clinical pharmacokinetics and toxicity: J. L. Abbruzzese et al., J. Clin. Oncol. 9, 491 (1991). Review of clinical studies: B. Lund et al., Cancer Treat. Rev. 19, 45-55 (1993).
Properties: Crystals from water, pH 8.5. [a]365 +425.36°; [a]D +71.51° (c = 0.96 in methanol). uv max (ethanol): 234, 268 (e 7810, 8560). LD10 i.v. in rats: 200 mg/m2 (Abbruzzese).
Optical Rotation: [a]365 +425.36°; [a]D +71.51°
Absorption maximum: uv max (ethanol): 234, 268 (e 7810, 8560)
Toxicity data: LD10 i.v. in rats: 200 mg/m2 (Abbruzzese)
 
Derivative Type: Hydrochloride
CAS Registry Number: 122111-03-9
Molecular Formula: C9H11F2N3O4.HCl
Molecular Weight: 299.66
Percent Composition: C 36.07%, H 4.04%, F 12.68%, N 14.02%, O 21.36%, Cl 11.83%
Properties: Crystals from water-acetone, mp 287-292° (dec). [a]D +48°; [a]365 +257.9° (c = 1.0 in deuterated water). uv max (water): 232, 268 nm (e 7960, 9360).
Melting point: mp 287-292° (dec)
Optical Rotation: [a]D +48°; [a]365 +257.9° (c = 1.0 in deuterated water)
Absorption maximum: uv max (water): 232, 268 nm (e 7960, 9360)
 
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Antimetabolites; Pyrimidine Analogs.