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CAS No 95975-55-6 , (Z)-Guggulsterone Search by region : India

  • Name: (Z)-Guggulsterone
  • Synonyms: (Z)-Guggulsterone;(17Z)-Pregna-4,17(20)-diene-3,16-dione;
  • CAS Registry Number:
  • Density: 1.1 g/cm3
  • Refractive index: 1.557
  • Water Solubility: DMSO: 5 mg/mL
  • Safety Statements: R37
  • Hazard Symbols: Xi: Irritant;
  • Molecular Weight: 312.45
  • InChI: InChI=1S/C14H12Cl2O/c15-12-5-1-10(2-6-12)14(9-17)11-3-7-13(16)8-4-11/h1-8,14,17H,9H2
  • Risk Statements: S36
  • Molecular Formula: C21H28O2
  • Molecular Structure:CAS No:95975-55-6 (Z)-Guggulsterone

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95975-55-6 Guggulsterones

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95975-55-6 Guggulsterones

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References of (Z)-Guggulsterone
Title: Guggulsterone
CAS Registry Number: 95975-55-6
CAS Name: Pregna-4,17(20)-diene-3,16-dione
Molecular Formula: C21H28O2
Molecular Weight: 312.45
Percent Composition: C 80.72%, H 9.03%, O 10.24%
Literature References: Bioactive component in guggulu, q.v., the gum resin of the Ayurvedic medicinal plant, Commiphora mukul, Burseraceae, used in treatment of lipid disorders. Both the E- and Z- isomers are naturally occurring and bioactive. Synthesis and stereochemistry: W. R. Benn, R. M. Dodson, J. Org. Chem. 29, 1142 (1964). Isoln from guggulu: V. D. Patil et al., Tetrahedron 28, 2341 (1972). HPLC determn of isomers in serum: N. Verma et al., J. Chromatogr. B 708, 243 (1998). LC determn of isomers in commercial guggulu formulations: M. Nagarajan et al., J. AOAC Int. 84, 24 (2001). Inhibition of the bile acid receptor FXR and cholesterol lowering activity: N. L. Urizar et al., Science 296, 1703 (2002). Brief review of proposed mechanism of action: C. J. Sinal, F. J. Gonzalez, Trends Endocrinol. Metab. 13, 275-276 (2002).
 
Derivative Type: E-Form
CAS Registry Number: 39025-24-6
Properties: Prisms from aq methanol, mp 170-171.5°. [a]D26 -30° (c = 1 in chloroform). uv max (methanol): 241 nm (e 27600).
Melting point: mp 170-171.5°
Optical Rotation: [a]D26 -30° (c = 1 in chloroform)
Absorption maximum: uv max (methanol): 241 nm (e 27600)
 
Derivative Type: Z-Form
CAS Registry Number: 39025-23-5
Properties: Crystals from aq methanol, mp 188-190°. [a]D26 -61° (c = 1 in chloroform). uv max (methanol): 241 nm (e 25000).
Melting point: mp 188-190°
Optical Rotation: [a]D26 -61° (c = 1 in chloroform)
Absorption maximum: uv max (methanol): 241 nm (e 25000)