Home > Name List By other > [(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl] (2S)-2-formamido-4-methylpentanoate India

CAS No 96829-58-2 , [(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl]
(2S)-2-formamido-4-methylpentanoate Search by region : India

  • Name: [(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl]
    (2S)-2-formamido-4-methylpentanoate
  • Synonyms: (-)-Tetrahydrolipstatin; Tetrahydrolipstatin;[(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl]
    (2S)-2-formamido-4-methylpentanoate; Alli; Orlipastatum [INN-Latin]; Orlipastat; THLP;Xenical; 96829-58-2;
  • CAS Registry Number:
  • Melting Point: <50 °C
  • Flash Point: 326.3 ºC
  • Boiling Point: 615.9 ºC at 760 mmHg
  • Density: 0.976 g/cm3
  • Refractive index: 1.469
  • Water Solubility: DMSO: 19 mg/mL in water
  • Flash Point: 326.3 ºC
  • Molecular Weight: 495.73482
  • InchiKey: AHLBNYSZXLDEJQ-FWEHEUNISA-N
  • InChI: InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-
    31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,
    (H,30,31)/t24-,25-,26-,27-/m0/s1
  • Molecular Formula: C29H53NO5
  • Molecular Structure:CAS No:96829-58-2 [(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl]<br />(2S)-2-formamido-4-methylpentanoate

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96829-58-2 ORLISTAT

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96829-58-2 Orlistat

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96829-58-2 Orlistat

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References of [(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl]
(2S)-2-formamido-4-methylpentanoate
Title: Orlistat
CAS Registry Number: 96829-58-2
CAS Name: N-Formyl-L-leucine (1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester
Synonyms: N-formyl-L-leucine ester with (3S,4S)-3-hexyl-4-[(2S)-2-hydroxytridecyl]-2-oxetanone; (-)-tetrahydrolipstatin; orlipastat
Manufacturers' Codes: Ro-18-0647
Trademarks: Xenical (Hoffmann-La Roche)
Molecular Formula: C29H53NO5
Molecular Weight: 495.73
Percent Composition: C 70.26%, H 10.78%, N 2.83%, O 16.14%
Literature References: Pancreatic lipase inhibitor. Isoln from fermentation broth of Streptomyces toxytricini: P. Hadvary et al., EP 129748; eidem, US 4598089 (1985, 1986 both to Hoffmann-LaRoche). Structural elucidation: E. Hochuli et al., J. Antibiot. 40, 1086 (1987). Synthesis and absolute configuration: P. Barbier, F. Schneider, Helv. Chim. Acta 70, 196 (1987). Total synthesis: S. Hanessian et al., J. Org. Chem. 58, 7768 (1993). Mechanism of action: B. Borgstr?m, Biochim. Biophys. Acta 962, 308 (1988). Clinical pharmacology: J. B. Hauptman et al., Am. J. Clin. Nutr. 55, 309S (1992). Clinical trial: M. H. Davidson et al., J. Am. Med. Assoc. 281, 235 (1999). Review of pharmacology and clinical efficacy in treatment of obesity: W. McNeely, P. Benfield, Drugs 56, 241-249 (1998). Evaluation of long-term efficacy and tolerability: J. Hauptman et al., Arch. Fam. Med. 9, 160 (2000).
Properties: Crystals, mp 43°. [a]D20 -32.0° (c = 1 in chloroform).
Melting point: mp 43°
Optical Rotation: [a]D20 -32.0° (c = 1 in chloroform)
Therap-Cat: Antiobesity agent.
Keywords: Antiobesity Agent.