Home > Name List By 1 > 1-ethyl-6, 8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid

CAS No 98079-51-7 , 1-ethyl-6,
8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid

  • Name: 1-ethyl-6,
    8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
  • Synonyms: 98079-51-7; Lomefloxacine [French]; Lomefloxacinum; Lomefloxacino; Lomefloxacino [Spanish];Lomefloxacine; LFLX;1-ethyl-6,
    8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid; Lomefloxacinum [Latin];
  • CAS Registry Number:
  • Transport: 25kgs
  • Melting Point: 239-240 C
  • Density: 1.342 g/cm3
  • Refractive index: 1.547
  • Water Solubility: Insoluble
  • Safety Statements: S26;S36;
  • Hazard Symbols: UN NO.
  • Molecular Weight: 351.347866
  • InchiKey: ZEKZLJVOYLTDKK-UHFFFAOYSA-N
  • InChI: InChI=1S/C17H19F2N3O3/c1-3-21-8-11(17(24)25)16(23)10-6-12(18)15(13(19)14
    (10)21)22-5-4-20-9(2)7-22/h6,8-9,20H,3-5,7H2,1-2H3,(H,24,25)
  • Risk Statements: 22-36/37/38
  • Molecular Formula: C17H19F2N3O3
  • Molecular Structure:CAS No:98079-51-7 1-ethyl-6,<br />8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
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98079-51-7 Lomefloxacin

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98079-51-7 lomefloxacin

  • China Taiyuan RHF CO., ltd. [Manufacturers]
  • Tel: 0351-7436719
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  • Address: Shuangta South Alley 46,2-1, YingZe Area,Taiyuan, ShanXi null,ShanXiChina
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98079-51-7 lomefloxacin

  • China Syntechem Co.,Ltd [Manufacturer]
  • Tel: +86-519-89882658
  • Fax: +86-519-8512 5369
  • Address: Syntechem Co.,Ltd
    18 South Zhulin Rd.
    Tianning district,Changzhou
    Jiangsu China 213022 null,nullChina
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98079-51-7 lomefloxacin

  • China Boronsyn Co.,Ltd [Manufacturer]
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  • Address: 1213 JunMin Road,Pudong,China null,nullChina
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98079-51-7 LOMEFLOXACIN

  • China ORICHEM INTERNATIONAL LTD. [Manufacturer, Trading Company]
  • Tel: 86-0571-85270505
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98079-51-7 LOMEFLOXACIN HYDROCHLORIDE

  • Germany BIOTREND Chemikalien GmbH [Manufacturer]
  • Tel: ++49 (0)2 21 9 49 83 20
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  • Address: BIOTREND Chemikalien GmbH
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    Germany null,nullGermany
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98079-51-7 Lomefloxacin Hydrochloride

  • United States Tecoland Corporation null
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  • Address: 100 Menlo Park Drive, Suite 316, Edison, New Jersey 08837-2428, null,nullUnited States
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98079-51-7 LOMEFLOXACIN HYDROCHLORIDE

  • Switzerland BIOTREND Chemicals AG [Manufacturer]
  • Tel: +41 44 805 76 76
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  • Address: BIOTREND Chemicals AG
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98079-51-7 Lomefloxacin Hydrochloride

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References of 1-ethyl-6,
8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
Title: Lomefloxacin
CAS Registry Number: 98079-51-7
CAS Name: 1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid
Molecular Formula: C17H19F2N3O3
Molecular Weight: 351.35
Percent Composition: C 58.11%, H 5.45%, F 10.81%, N 11.96%, O 13.66%
Literature References: Fluorinated quinolone antibacterial. DNA gyrase antagonist. Prepn: Y. Itoh et al., DE 3433924; eidem, US 4528287 (both 1985 to Hokuriku Pharm.). In vitro and in vivo activity: T. Hirose et al., Antimicrob. Agents Chemother. 31, 854 (1987). Comparative antibacterial spectrum in vitro: R. Wise et al., ibid. 32, 617 (1988). HPLC determn in urine and bile and preliminary pharmacokinetics in rats: A. Saito et al., ibid. 156. Photochemistry study: E. Fasani et al., Eur. J. Org. Chem.2004, 5075. Supplement on antibacterial spectrum, pharmacokinetics and clinical efficacy: Chemotherapy (Tokyo) 36, Suppl. 2, 1-1418 (1988). Comprehensive description: Y. D. Sanzgiri et al., Anal. Profiles Drug Subs. Excip. 23, 321-369 (1994).
Properties: Colorless needles from ethanol, mp 239-240.5°. Soly at 25° (mg/ml): 1.03 at ionic strength 0.15 M NaCl. uv max (0.15 M acetate buffer, pH 5): 226, 288, 320 nm (aM ′ 10-3 15.5, 36.7, 13.5); uv max (0.05 M phosphate buffer, pH 7): 282, 326 nm (aM ′ 10-3 31.5, 13.3); uv max (0.15 M borate buffer, m = 0.15 M with NaCl, pH 9): 282, 328 nm (aM ′ 10-3 29.3, 13.2). LD50 in mice (mg/kg): 245.6 i.v.; >4000 orally (Itoh).
Melting point: mp 239-240.5°
Absorption maximum: uv max (0.15 M acetate buffer, pH 5): 226, 288, 320 nm (aM ′ 10-3 15.5, 36.7, 13.5); uv max (0.05 M phosphate buffer, pH 7): 282, 326 nm (aM ′ 10-3 31.5, 13.3); uv max (0.15 M borate buffer, m = 0.15 M with NaCl, pH 9): 282, 328 nm (aM ′ 10-3 29.3, 13.2)
Toxicity data: LD50 in mice (mg/kg): 245.6 i.v.; >4000 orally (Itoh)
 
Derivative Type: Monohydrochloride
CAS Registry Number: 98079-52-8
Manufacturers' Codes: NY-198; SC-47111
Trademarks: Bareon (Hokuriku); Chimono (Lusofarmaco); Lomebact (Shionogi); Maxaquin (Pharmacia); Okacin (Novartis); Okacyn (Novartis)
Molecular Formula: C17H19F2N3O3.HCl
Molecular Weight: 387.81
Percent Composition: C 52.65%, H 5.20%, F 9.80%, N 10.84%, O 12.38%, Cl 9.14%
Properties: Colorless needles from water, mp 290-300° (dec).
Melting point: mp 290-300° (dec)
 
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Synthetic); Quinolones and Analogs.