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CAS No 98769-81-4 , Reboxetine Search by region : China

  • Name: Reboxetine
  • Synonyms: (2R)-2-[(R)-(2-Ethoxyphenoxy)phenylmethyl]morpholine;Reboxetine;
  • CAS Registry Number:
  • Molecular Weight: 313.40
  • InChI: InChI=1S/C19H23NO3/c1-2-21-16-10-6-7-11-17(16)23-19(15-8-4-3-5-9-15)18-14-20-12-13-22-18/h3-11,18-20H,2,12-14H2,1H3/t18-,19-/m1/s1
  • Molecular Formula: C19H23NO3
  • Molecular Structure:CAS No:98769-81-4 Reboxetine

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References of Reboxetine
Title: Reboxetine
CAS Registry Number: 98769-81-4
CAS Name: (2R)-rel-2-[(R)-(2-Ethoxyphenoxy)phenylmethyl]morpholine
Synonyms: (±)-(2R*)-2-[(aR*)-a-(o-ethoxyphenoxy)benzyl]morpholine
Molecular Formula: C19H23NO3
Molecular Weight: 313.39
Percent Composition: C 72.82%, H 7.40%, N 4.47%, O 15.32%
Literature References: Selective noradrenaline reuptake inhibitor. Prepn: P. Melloni et al., DE 2901032; eidem, US 4229449 (1979, 1980 both to Farmitalia Carlo Erba); eidem et al., Eur. J. Med. Chem. - Chim. Ther. 19, 235 (1984). Configuration: P. Melloni et al., Tetrahedron 41, 1393 (1985). HPLC determn of enantiomers in plasma: E. Frigerio et al., J. Chromatogr. A 660, 351 (1994). Metabolism: G. Cocchiara et al., Eur. J. Drug Metab. Pharmacokinet. 16, 231 (1991). Stereoselective kinetics: M. S. Benedetti et al., Chirality 7, 285 (1995). Clinical pharmacokinetics: C. Pellizzoni et al., Biopharm. Drug Dispos. 17, 623 (1996). Clinical trial in depression and social phobia: S. A. Montgomery, J. Psychopharmacol. 11, Suppl., S9 (1997); A. Dubini et al., ibid. S17.
Properties: mp 170-171°.
Melting point: mp 170-171°
 
Derivative Type: Methanesulfonate
CAS Registry Number: 98769-82-5
Synonyms: Reboxetine mesylate
Manufacturers' Codes: FCE-20124
Trademarks: Edronax (Pharmacia & Upjohn); Prolift (Pfizer); Vestra (Pharmacia & Upjohn)
Molecular Formula: C19H23NO3.CH3SO3H
Molecular Weight: 409.50
Percent Composition: C 58.66%, H 6.65%, N 3.42%, O 23.44%, S 7.83%
Properties: mp 145-146°.
Melting point: mp 145-146°
 
Therap-Cat: Antidepressant.
Keywords: Antidepressant.