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CAS No 99464-64-9 , ethyl
1-[[2-methyl-1,1-dioxo-3-(pyridin-2-ylcarbamoyl)-1λ

  • Name: ethyl
    1-[[2-methyl-1,1-dioxo-3-(pyridin-2-ylcarbamoyl)-1λ
  • Synonyms: Ampiroxicamum [Latin];ethyl
    1-[[2-methyl-1,1-dioxo-3-(pyridin-2-ylcarbamoyl)-1λ CP 65703;Flucam; Ampiroxicamum; 99464-64-9;6,
    2-benzothiazin-4-yl]oxy]ethyl carbonate; CP-65703;
  • CAS Registry Number:
  • Density: 1.44 g/cm3
  • Refractive index: 1.629
  • Molecular Weight: 447.46164
  • InchiKey: LSNWBKACGXCGAJ-UHFFFAOYSA-N
  • InChI: InChI=1S/C20H21N3O7S/c1-4-28-20(25)30-13(2)29-18-14-9-5-6-10-15(14)31
    (26,27)23(3)17(18)19(24)22-16-11-7-8-12-21-16/h5-13H,4H2,1-3H3,(H,21,22,
    24)
  • Molecular Formula: C20H21N3O7S
  • Molecular Structure:CAS No:99464-64-9 ethyl<br />1-[[2-methyl-1,1-dioxo-3-(pyridin-2-ylcarbamoyl)-1λ

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References of ethyl
1-[[2-methyl-1,1-dioxo-3-(pyridin-2-ylcarbamoyl)-1λ
Title: Ampiroxicam
CAS Registry Number: 99464-64-9
CAS Name: Carbonic acid ethyl 1-[[2-methyl-3-[(2-pyridinylamino)carbonyl]-2H-1,2-benzothiazin-4-yl]oxy]ethyl ester S,S-dioxide
Synonyms: (±)-4-(1-hydroxyethoxy)-2-methyl-N-2-pyridyl-2H-1,2-benzothiazine-3-carboxamide ethyl carbonate (ester) 1,1-dioxide; 4-[1-(ethoxycarbonyloxy)ethoxy]-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
Manufacturers' Codes: CP-65703
Trademarks: Flucam (Pfizer)
Molecular Formula: C20H21N3O7S
Molecular Weight: 447.46
Percent Composition: C 53.68%, H 4.73%, N 9.39%, O 25.03%, S 7.17%
Literature References: Prodrug of piroxicam, q.v. Prepn: A. Marfat, EP 147177; idem, US 4551452 (both 1985 to Pfizer). Clinical pharmacokinetics: F. C. Falkner et al., Xenobiotica 20, 645 (1990). Toxicity study: M. Iijima et al., Oyo Yakuri 43, 1 (1992); C.A. 116, 187689k (1992). Pharmacology: T. J. Carty et al., Agents Actions 39, 157 (1993). Clinical trial in oral postoperative pain: K. Kurita et al., Oral. Ther. Pharmacol. 10, 138 (1991); in rheumatoid arthritis: S. Irimajiri et al., Jpn. J. Inflammation 12, 81 (1992).
Properties: White crystals from toluene, mp 159-161°. LD50 orally in male, female rats: 1798, 747 mg/kg (Iijima).
Melting point: mp 159-161°
Toxicity data: LD50 orally in male, female rats: 1798, 747 mg/kg (Iijima)
Therap-Cat: Anti-inflammatory.
Keywords: Anti-inflammatory (Nonsteroidal); Thiazinecarboxamides.