RX-3117

• Product NameRX-3117
  CAS No.865838-26-2
  Purity>98%
  Min Quantity
  Price~
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Detailed Description

RX-3117RX-3117(TV-1360; Fluorocyclopentenylcytosine) is novel a cytidine analog; shows anticancer activity in several cancer cell lines, including gemcitabine-resistant variants.

IC50 value: 0.4- >30 nM (15 cancer cell lines) [1]

Target: cytidine analog

in vitro: RX-3117 showed a different sensitivity profile compared to cyclopentenyl-cytosine (CPEC) and azacytidine, substrates for uridine-cytidine-kinase (UCK).RX-3117 was a very poor substrate for cytidine deaminase (66,000-fold less than gemcitabine).

Target:Cathepsin

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