Home > Name List By other > (4S,4aS,5aR,12aR)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3, 12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide

CAS No 10118-90-8 , (4S,4aS,5aR,12aR)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,
12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide

  • Name: (4S,4aS,5aR,12aR)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,
    12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide
  • Synonyms: Minociclina [INN-Spanish]; Dynacin;(4S,4aS,5aR,12aR)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,
    12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide; Minocyclinum [INN-Latin]; minociclinum; Minocyclinum; Minociclina; Minocin;Minocyclin;
  • CAS Registry Number:
  • Density: 1.553 g/cm3
  • Refractive index: 1.717
  • Safety Statements: Poison by intraperitoneal, intravenous, and intracerebral routes. Moderately toxic by ingestion. Human systemic effects by ingestion: interstitial nephritis, proteinuris and hematuris. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
  • EINECS: 237-099-7
  • Molecular Weight: 457.47638
  • InchiKey: FFTVPQUHLQBXQZ-KVUCHLLUSA-N
  • InChI: InChI=1S/C23H27N3O7/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19
    (29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28/h5-6,9,11,17,27-28,
    31,33H,7-8H2,1-4H3,(H2,24,32)/t9-,11-,17-,23-/m0/s1
  • Molecular Formula: C23H27N3O7
  • Molecular Structure:CAS No:10118-90-8 (4S,4aS,5aR,12aR)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,<br />12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide

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References of (4S,4aS,5aR,12aR)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,
12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide
Title: Minocycline
CAS Registry Number: 10118-90-8
CAS Name: [4S-(4a,4aa,5aa,12aa)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide
Synonyms: 7-dimethylamino-6-demethyl-6-deoxytetracycline
Molecular Formula: C23H27N3O7
Molecular Weight: 457.48
Percent Composition: C 60.38%, H 5.95%, N 9.19%, O 24.48%
Literature References: Second generation tetracycline antibiotic. Prepn: J. Petisi, J. H. Boothe, US 3226436 (1965 to Am. Cyanamid); M. J. Martell, J. H. Boothe, J. Med. Chem. 10, 44 (1967); R. F. R. Church et al., J. Org. Chem. 36, 723 (1971). HPLC determn in tissue and serum: W. R. Wrightson et al., J. Chromatogr. B 706, 358 (1998). Comprehensive description: V. Zbinovsky, G. P. Chrekian, Anal. Profiles Drug Subs. 6, 323-339 (1977). Series of articles on toxicology and metabolism: Toxicol. Appl. Pharmacol. 11, 128-183 (1967). Review of antibacterial activity and pharmacology: M. Jonas, B. A. Cunha, Ther. Drug Monit. 4, 137-145 (1982); of clinical safety and efficacy in acne: K. Freeman, Br. J. Clin. Pract. 43, 112-115 (1989). Clinical evaluation in periodontal disease: R. J. Oringer et al., J. Periodontol. 73, 835 (2002).
Properties: Bright yellow-orange amorphous solid. [a]D25 -166° (c = 0.524). uv max (0.1N HCl): 352, 263 nm (log e 4.16, 4.23); (0.1N NaOH): 380, 243 nm (log e 4.30, 4.38).
Optical Rotation: [a]D25 -166° (c = 0.524)
Absorption maximum: uv max (0.1N HCl): 352, 263 nm (log e 4.16, 4.23); (0.1N NaOH): 380, 243 nm (log e 4.30, 4.38)
 
Derivative Type: Hydrochloride
CAS Registry Number: 13614-98-7
Trademarks: Arestin (OroPharma); Dynacin (Medicis); Klinomycin (Valeant); Minocin (Wyeth); Vectrin (Medicis)
Molecular Formula: C23H27N3O7.HCl
Molecular Weight: 493.94
Percent Composition: C 55.93%, H 5.71%, N 8.51%, O 22.67%, Cl 7.18%
Properties: Yellow crystalline powder. Slightly hygroscopic; sensitive to light and to surface oxidation.
 
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); Tetracyclines.