Home > Name List By 6 > 6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalene-2-carboxylic acid

CAS No 106685-40-9 , 6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalene-2-carboxylic acid

  • Name: 6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalene-2-carboxylic acid
  • Synonyms: Differine; Adaferin; Adapaleno [INN-Spanish];6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalene-2-carboxylic acid;Differin; Adapalenum [INN-Latin]; Adapalenum; 106685-40-9; Adapaleno;
  • CAS Registry Number:
  • Density: 1.233 g/cm3
  • Refractive index: 1.654
  • Molecular Weight: 412.52012
  • InchiKey: LZCDAPDGXCYOEH-UHFFFAOYSA-N
  • InChI: InChI=1S/C28H28O3/c1-31-26-7-6-23(21-2-3-22-12-24(27(29)30)5-4-20(22)11-
    21)13-25(26)28-14-17-8-18(15-28)10-19(9-17)16-28/h2-7,11-13,17-19H,8-10,
    14-16H2,1H3,(H,29,30)
  • Molecular Formula: C28H28O3
  • Molecular Structure:CAS No:106685-40-9 6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalene-2-carboxylic acid
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106685-40-9 Adapalene

  • China Haihang Industry Co., Ltd. null
  • Tel: +86-(531)-88032799
  • Fax: +86-(531)-85821093
  • Address: 2/F, East Tower, Bldg 12, No. 2 Qilihe Road, Jinan 250100, null,nullChina
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106685-40-9 Adapalene

  • Adapalene
  • United States RIA International [Manufacturer]
  • Tel: 19735811282
  • Fax: 19735811283
  • Address: 11 Melanie Lane #17 East Hanover 07936 NJ UNITED STATES NJ,nullUnited States
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106685-40-9 ADAPALENE

  • China Hangzhou Hysen Pharma Co., Ltd [Manufacturer]
  • Tel: 86-571-89937383
  • Fax: 86-571-89937386
  • Address: Hangzhou Hysen Pharma Co., Ltd
    NO. 391, WEN'ER ROAD
    HANGZHOU CHINA null,nullChina
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106685-40-9 Adapalene

  • China Beijing Mediking Biopharm Co., Ltd [Manufacturer]
  • Tel: +86-10-81769620/ +86-10-81769521
  • Fax: +86-10-81769652
  • Address: Hongxianghong Incubator, Beiqijia Town,
    Changping District
    Beijing China null,nullChina
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106685-40-9 Adapalene

  • China Shanghai Xunxin Chemical Co., Ltd [Manufacturers]
  • Tel: +86-(21)-38218795
  • Fax: +86-(21)-38218795
  • Address: 580 Lane, Kanghong Road, Pudong New District, Shanghai 201315, Shanghai,ShanghaiChina
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106685-40-9 Adapalene

  • China YiPeng Chemical [Manufacturers]
  • Tel: 571 85376369
  • Fax: 571 88233092
  • Address: Building 4,High-tech Industrial Park,No. 588 Feijiatang Road,Xiacheng District, Hangzhou, China null,ZheJiangChina
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106685-40-9 Adapalene

  • China suchem pharma co.,limited [Manufacturers]
  • Tel: 86-57781172668
  • Fax: 8657785505511
  • Address: wenzhou, China Wenzhou,ZhejiangChina
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106685-40-9 Adapalene

  • China Laiwu Hehui Chemical Co.,Ltd. null
  • Tel: +86-(531)-88772589
  • Fax: +86-(531)-88772589
  • Address: Huashan Rd., Jinan City, Shandong 250000, null,nullChina
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106685-40-9 Adefovir Dipivolix

  • Adefovir Dipivolix
  • Germany Paragos [Manufacturer]
  • Tel: +49 69 41 09 21 91
  • Fax: +49 69 42 69 45 85
  • Address: Alt Fechenheim 3460386 Frankfurt/MainGERMANY Frankfurt/Main,nullGermany
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106685-40-9 Adapalene

  • China Boronsyn Co.,Ltd [Manufacturer]
  • Tel: +86-21-58407925
  • Fax: +86-21-58408291
  • Address: 1213 JunMin Road,Pudong,China null,nullChina
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References of 6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalene-2-carboxylic acid
Title: Adapalene
CAS Registry Number: 106685-40-9
CAS Name: 6-(4-Methoxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid
Synonyms: 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid
Manufacturers' Codes: CD-271
Trademarks: Differin (Galderma)
Molecular Formula: C28H28O3
Molecular Weight: 412.52
Percent Composition: C 81.52%, H 6.84%, O 11.64%
Literature References: Retinoid selective for retinoic acid receptor (RAR) subtypes b and g. Prepn: B. Shroot et al., EP 199636; eidem, US 4717720 (1986, 1988 both to Cent. Int. Recher. Dermatol.); and structure-activity study: B. Charpentier et al., J. Med. Chem. 38, 4993 (1995). Pilot-scale synthesis: Z. Liu, J. Xiang, Org. Process Res. Dev. 10, 285 (2006). HPLC determn in plasma and tissue: R. Ruhl, H. Nau, Chromatographia 45, 269 (1997). Clinical pharmacology: C. E. M. Griffiths et al., J. Invest. Dermatol. 101, 325 (1993). Clinical trial in acne: A. Shalita et al., J. Am. Acad. Dermatol. 34, 482 (1996). Reviews of pharmacology and clinical potential: B. A. Bernard, Skin Pharmacol. 6, Suppl. 1, 61-69 (1993); R. N. Brogden, K. L. Goa, Drugs 53, 511-519 (1997); of clinical use in acne vulgaris: J. Waugh et al., Drugs 64, 1465-1478 (2004).
Properties: White crystals from THF and ethyl acetate, mp 319-322°. pK 4.2. Stable to light.
Melting point: mp 319-322°
pKa: pK 4.2
Therap-Cat: Antiacne.
Keywords: Antiacne.