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CAS No 106685-40-9 , 6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalene-2-carboxylic acid

  • Name: 6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalene-2-carboxylic acid
  • Synonyms: Differine; Adaferin; Adapaleno [INN-Spanish];6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalene-2-carboxylic acid;Differin; Adapalenum [INN-Latin]; Adapalenum; 106685-40-9; Adapaleno;
  • CAS Registry Number:
  • Density: 1.233 g/cm3
  • Refractive index: 1.654
  • Molecular Weight: 412.52012
  • InchiKey: LZCDAPDGXCYOEH-UHFFFAOYSA-N
  • InChI: InChI=1S/C28H28O3/c1-31-26-7-6-23(21-2-3-22-12-24(27(29)30)5-4-20(22)11-
    21)13-25(26)28-14-17-8-18(15-28)10-19(9-17)16-28/h2-7,11-13,17-19H,8-10,
    14-16H2,1H3,(H,29,30)
  • Molecular Formula: C28H28O3
  • Molecular Structure:CAS No:106685-40-9 6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalene-2-carboxylic acid
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106685-40-9 Adapalene

  • China Kouting Chemical Co.,Ltd [Importer/Exporter]
  • Tel: +86-(21)-58116473
  • Fax: +86-(21)-61094103
  • Address: Hunan Road, Pudong New District, Shanghai, Shanghai 201318, shanghai,shanghaiChina
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106685-40-9 Adapalene

  • China Ningbo Inno Pharmchem Co., Ltd. [Manufacturers]
  • Tel: +86-(574)-87319282
  • Fax: +86-(574)-56877908
  • Address: 5F, Building 4, 1035 Guangxian Rd., Ningbo Hi-Tech Park, Ningbo, Zhejiang 315040, Ningbo,ZhejiangChina
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106685-40-9 Adapalene

  • India Shreeji Pharma International [Manufacturers]
  • Tel: +91-265-3019110
  • Fax: +91-265-2465036
  • Address: FF/10, Narsinghdham Complex, Sangam Chararasta, Harni Road, Vadodara, Gujarat 390018, Vadodara,GujaratIndia
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106685-40-9 Adapalene

  • Adapalene, USP28
  • China Alway Chem, China [Manufacturer]
  • Tel: +86-532-8586-4000, 8586-5000
  • Fax: +86-532-8666-0350
  • Address: NO.51, TAIPING ROAD, QINGDAO, CHINA. 266001 null,SHANDONGChina
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106685-40-9 Adapalene

  • AdapaleneAdapalene, 99%
  • China Beijing HuameiHuli Biochem Ltd [Manufacturers]
  • Tel: 010-86181995
  • Fax: 010-86860610
  • Address: Beijing TongZhou District Beijing,BeijingChina
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106685-40-9 Adefovir Dipivoxil, 99%

  • Adefovir Dipivoxil, 99%
  • China Pleapharma Co.,Ltd [Manufacturer]
  • Tel: 86 23 67030808
  • Fax: 86 23 67030809
  • Address: 22F,Jingxin center,No.70 Xingguang Road,Yubei Zone,Chongqing402232 chongqingCHINA chongqing,nullChina
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106685-40-9 Adapalene

  • China Hangzhou Starshine Pharmaceutical Co., LTD [Manufacturers]
  • Tel: +86-571-89939756 85122191
  • Fax: +86-571-85122157
  • Address: ROOM A, 20 TH FLOOR, WEST BUILDING, INTERNATIONAL GARDEN, NO.160 TIANMUSHAN ROAD, HANGZHOU, CHINA null,ZhejiangChina
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106685-40-9 Adapalene

  • China Ningbo Huajia Chemical Co., Ltd. null
  • Fax: 86-574-87065629
  • Address: 10th Floor, Lishi Building, No.787 Baizhang East Road, Ningbo, Zhejiang, China null,nullChina
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106685-40-9 Adapalene

  • China Pharmasi Chemicals Co.,Ltd null
  • Fax: +86-21-57819315
  • Address: Room 205, Renlesancun50-29,songjiang,shanghai,China null,nullChina
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106685-40-9 Adapalene

  • Adapalene Molecular Formula 锛?28H28O3 cas no. 106685-40-9 molecular weight : 412.52 Purity:98.00%
  • China Wuhan Entai Technology Co., Ltd [Manufacturer, Other]
  • Tel: 86-027-82330560
  • Address: null null,nullChina
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References of 6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalene-2-carboxylic acid
Title: Adapalene
CAS Registry Number: 106685-40-9
CAS Name: 6-(4-Methoxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid
Synonyms: 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid
Manufacturers' Codes: CD-271
Trademarks: Differin (Galderma)
Molecular Formula: C28H28O3
Molecular Weight: 412.52
Percent Composition: C 81.52%, H 6.84%, O 11.64%
Literature References: Retinoid selective for retinoic acid receptor (RAR) subtypes b and g. Prepn: B. Shroot et al., EP 199636; eidem, US 4717720 (1986, 1988 both to Cent. Int. Recher. Dermatol.); and structure-activity study: B. Charpentier et al., J. Med. Chem. 38, 4993 (1995). Pilot-scale synthesis: Z. Liu, J. Xiang, Org. Process Res. Dev. 10, 285 (2006). HPLC determn in plasma and tissue: R. Ruhl, H. Nau, Chromatographia 45, 269 (1997). Clinical pharmacology: C. E. M. Griffiths et al., J. Invest. Dermatol. 101, 325 (1993). Clinical trial in acne: A. Shalita et al., J. Am. Acad. Dermatol. 34, 482 (1996). Reviews of pharmacology and clinical potential: B. A. Bernard, Skin Pharmacol. 6, Suppl. 1, 61-69 (1993); R. N. Brogden, K. L. Goa, Drugs 53, 511-519 (1997); of clinical use in acne vulgaris: J. Waugh et al., Drugs 64, 1465-1478 (2004).
Properties: White crystals from THF and ethyl acetate, mp 319-322°. pK 4.2. Stable to light.
Melting point: mp 319-322°
pKa: pK 4.2
Therap-Cat: Antiacne.
Keywords: Antiacne.