Home > Name List By other > (2S)-2-[[2-[(2S,3S)-7-carboxy-3-(2-carboxyethyl)-17-ethenyl-12-ethyl-2, 8,13,18-tetramethyl-2,3,23, 24-tetrahydroporphyrin-5-...

CAS No 110230-98-3 , (2S)-2-[[2-[(2S,3S)-7-carboxy-3-(2-carboxyethyl)-17-ethenyl-12-ethyl-2,
8,13,18-tetramethyl-2,3,23,
24-tetrahydroporphyrin-5-yl]acetyl]amino]butanedioic acid

  • Name: (2S)-2-[[2-[(2S,3S)-7-carboxy-3-(2-carboxyethyl)-17-ethenyl-12-ethyl-2,
    8,13,18-tetramethyl-2,3,23,
    24-tetrahydroporphyrin-5-yl]acetyl]amino]butanedioic acid
  • Synonyms: Talaporfin [INN];(2S)-2-[[2-[(2S,3S)-7-carboxy-3-(2-carboxyethyl)-17-ethenyl-12-ethyl-2,
    8,13,18-tetramethyl-2,3,23,
    24-tetrahydroporphyrin-5-yl]acetyl]amino]butanedioic acid; N-Aspartyl chlorin e6; Monoaspartyl chlorin;Aspartyl chlorin; monoaspartyl chlorin e6; N-Aspartylchlorin e6;
  • CAS Registry Number:
  • Flash Point: 664.7°C
  • Boiling Point: 1175.5°Cat760mmHg
  • Density: 1.359
  • Refractive index: 1.64
  • Flash Point: 664.7°C
  • Molecular Weight: 711.76024
  • InchiKey: SIEXFRDYNDREBM-BRXYURPTSA-N
  • InChI: InChI=1S/C38H41N5O9/c1-7-20-16(3)24-12-26-18(5)22(9-10-32(45)46)35(42-
    26)23(11-31(44)41-30(37(49)50)15-33(47)48)36-34(38(51)52)19(6)27(43-36)
    14-29-21(8-2)17(4)25(40-29)13-28(20)39-24/h7,12-14,18,22,30,39-40H,1,
    8-11,15H2,2-6H3,(H,41,44)(H,45,46)(H,47,48)(H,49,50)(H,51,52)/t18-,22-,
    30-/m0/s1
  • Molecular Formula: C38H41N5O9
  • Molecular Structure:CAS No:110230-98-3 (2S)-2-[[2-[(2S,3S)-7-carboxy-3-(2-carboxyethyl)-17-ethenyl-12-ethyl-2,<br />8,13,18-tetramethyl-2,3,23,<br />24-tetrahydroporphyrin-5-yl]acetyl]amino]butanedioic acid

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110230-98-3 L-Aspartic acid,N-[2-[(7S,8S)-3-carboxy-7-(2-carboxyethyl)-13-ethenyl-18-ethyl-7,8-dihydro-2,8,12,17-tetramethyl-21H,23H-porphin-5-yl]acetyl]-

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References of (2S)-2-[[2-[(2S,3S)-7-carboxy-3-(2-carboxyethyl)-17-ethenyl-12-ethyl-2,
8,13,18-tetramethyl-2,3,23,
24-tetrahydroporphyrin-5-yl]acetyl]amino]butanedioic acid
Title: Talaporfin
CAS Registry Number: 110230-98-3
CAS Name: N-[[(7S,8S)-3-Carboxy-7-(2-carboxyethyl)-13-ethenyl-18-ethyl-7,8-dihydro-2,8,12,17-tetramethyl-21H,23H-porphin-5-yl]acetyl]-L-aspartic acid
Synonyms: (2S,3S)-18-carboxy-20-[N-(S)-1,2-dicarboxyethyl]carbamoylmethyl-13-ethyl-3,7,12,17-tetramethyl-8-vinylchlorin-2-propanoic acid; mono-L-aspartyl chlorin e6; NPe6
Molecular Formula: C38H41N5O9
Molecular Weight: 711.76
Percent Composition: C 64.12%, H 5.81%, N 9.84%, O 20.23%
Literature References: Semisynthetic derivative of chlorin e6, q.v. Photosensitizer activated at 664 nm by laser or light-emitting diode-based light infusion device. Causes irreversible tumor blood vessel closure. Prepn: J. C. Bommer, B. F. Burnham, EP 168831; eidem, US 4675338 (1986, 1987 both to Nippon Petrochemicals). Photophysical properties: J. D. Spikes, J. C. Bommer, J. Photochem. Photobiol. B 17, 135 (1993); L. Li et al., ibid. 67, 51 (2002). Chemical and NMR structural studies: S. Gomi et al., Heterocycles 48, 2231 (1998). Safety assessment in treatment of refractory solid tumors: R. A. Lustig et al., Cancer 98, 1767 (2003). Clinical evaluation in lung cancer: H. Kato et al., Lung Cancer 42, 103 (2003).
Properties: Dark blue-green powder. Sol in water. Absorption max (phosphate buffer, pH 7.4): 400, 654 nm (e 180000, 40000). Absorption max (p-dioxane): 401.7, 663.5 nm (EmM 111, 38). Hygroscopic and light sensitive. Store under vacuum; protect from light.
Absorption maximum: Absorption max (phosphate buffer, pH 7.4): 400, 654 nm (e 180000, 40000); Absorption max (p-dioxane): 401.7, 663.5 nm (EmM 111, 38)
 
Derivative Type: Tetrasodium salt
CAS Registry Number: 220201-34-3
Synonyms: Talaporfin sodium
Manufacturers' Codes: LS-11; ME-2906
Trademarks: Laserphyrin (Meiji)
Molecular Formula: C38H37N5Na4O9
Molecular Weight: 799.69
Percent Composition: C 57.07%, H 4.66%, N 8.76%, Na 11.50%, O 18.01%
 
Therap-Cat: Antineoplastic (photosensitizer).
Keywords: Antineoplastic (Photosensitizer).