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CAS No 111753-73-2 , 4-cyano-5,5-bis(4-methoxyphenyl)pent-4-enoic acid

  • Name: 4-cyano-5,5-bis(4-methoxyphenyl)pent-4-enoic acid
  • Synonyms: E-5510; 4-Cyano-5,5-bis(4-methoxyphenyl)-4-pentenoic acid;4-cyano-5,5-bis(4-methoxyphenyl)pent-4-enoic acid; E 5510;CCRIS 7283; 4-cyano-5,5-bis(4-methoxyphenyl)pent-4-enoic acid; E5510;
  • CAS Registry Number:
  • Flash Point: 305.6°C
  • Boiling Point: 581.6°Cat760mmHg
  • Density: 1.195g/cm3
  • Refractive index: 1.578
  • Flash Point: 305.6°C
  • Molecular Weight: 337.36916
  • InchiKey: GRVCTHTXJDYIHB-UHFFFAOYSA-N
  • InChI: InChI=1S/C20H19NO4/c1-24-17-8-3-14(4-9-17)20(16(13-21)7-12-19(22)23)15-
    5-10-18(25-2)11-6-15/h3-6,8-11H,7,12H2,1-2H3,(H,22,23)
  • Molecular Formula: C20H19NO4
  • Molecular Structure:CAS No:111753-73-2 4-cyano-5,5-bis(4-methoxyphenyl)pent-4-enoic acid

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111753-73-2 SATIGREL

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111753-73-2 SATIGREL

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References of 4-cyano-5,5-bis(4-methoxyphenyl)pent-4-enoic acid
Title: Satigrel
CAS Registry Number: 111753-73-2
CAS Name: 4-Cyano-5,5-bis(4-methoxyphenyl)-4-pentenoic acid
Manufacturers' Codes: E-5510
Molecular Formula: C20H19NO4
Molecular Weight: 337.37
Percent Composition: C 71.20%, H 5.68%, N 4.15%, O 18.97%
Literature References: Platelet aggregation inhibitor; inhibits phosphodiesterases and cyclooxygenase-1. Prepn: Y. Yamagishi et al., EP 238973; eidem, US 4978767 (1987, 1990 both to Eisai). Pharmacology: T. Fujimori et al., Arzneim.-Forsch. 37, 1143 (1987); eidem, Cardiovasc. Drug Rev. 9, 264 (1991). Selectivity for cyclooxygenase and phosphodiesterase isoforms: N. Nagakura et al., Biol. Pharm. Bull. 19, 828 (1996). GC-MS determn in plasma: Y. Yamano et al., J. Chromatogr. 528, 199 (1990). Clinical trial to prevent transient ischemic attacks: S. Maruyama et al., Angiology 46, 999 (1995).
Properties: Crystals from ethyl acetate/hexane, mp 124-125°.
Melting point: mp 124-125°
Therap-Cat: Antithrombotic.
Keywords: Antithrombotic; Phosphodiesterase Inhibitor.