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CAS No 113-53-1 , 1-Propanamine,3-dibenzo[b,e]thiepin-11(6H)-ylidene-N,N-dimethyl- Search by region : India

  • Name: 1-Propanamine,3-dibenzo[b,e]thiepin-11(6H)-ylidene-N,N-dimethyl-
  • Synonyms: Dibenzo[b,e]thiepin-D11(6H),g-propylamine, N,N-dimethyl-(7CI,8CI); Dosulepine; Prothiaden; Dibenzo[b,e]thiepin, 1-propanamine deriv.; IZ 914;Dothep; Dothiepin; Dosulepin;1-Propanamine,3-dibenzo[b,e]thiepin-11(6H)-ylidene-N,N-dimethyl-; Prothiadene;
  • CAS Registry Number:
  • Transport: 3249
  • Melting Point: 55-57
  • Density: 1.148 g/cm3
  • Safety Statements: Human systemic effects by ingestion: central nervous system including coma, and cardiac arrhythmia. Mutation data reported. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and SOx.
  • EINECS: 204-031-2
  • Molecular Weight: 295.47
  • InChI: InChI=1/C19H21NS/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19/h3-6,8-12H,7,13-14H2,1-2H3/b17-11-
  • Molecular Formula: C19H21 N S
  • Molecular Structure:CAS No:113-53-1 1-Propanamine,3-dibenzo[b,e]thiepin-11(6H)-ylidene-N,N-dimethyl-

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113-53-1 dothiepin

  • IUPAC NAME-E,Z)-3-(dibenzo[b,e]thiepin-11(6H)-ylidene)-N,N-dimethylpropan-1-amine MOLECULAR FORMULA-C19H21NS MOLAR MASS-295.45 g/mol Dosulepin is used for low-level anxiety, depression and similar disorders, as well as the treatment of chronic and on...
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References of 1-Propanamine,3-dibenzo[b,e]thiepin-11(6H)-ylidene-N,N-dimethyl-
Title: Dothiepin
CAS Registry Number: 113-53-1
CAS Name: 3-Dibenzo[b,e]thiepin-11(6H)-ylidene-N,N-dimethyl-1-propanamine
Synonyms: N,N-dimethyldibenzo[b,e]thiepin-D11(6H),g-propylamine; 11-(3-dimethylaminopropylidene)-6,11-dihydrodibenzo[b,e]thiepin; dosulepin
Molecular Formula: C19H21NS
Molecular Weight: 295.44
Percent Composition: C 77.24%, H 7.16%, N 4.74%, S 10.85%
Literature References: Tricyclic antidepressant. Prepn: M. Protiva et al., Experientia 18, 326 (1962); BE 618591; M. Protiva et al., US 3527766 (1962, 1970 both to SPOFA); M. Rajsner, M. Protiva, Cesk. Farm. 11, 404 (1962), C.A. 59, 2772g (1963). Synthesis of isomers: M. Rajsner et al., Collect. Czech. Chem. Commun. 34, 1963 (1969). Pharmacology: J. Metysova et al., Arzneim.-Forsch. 13, 1039 (1963). Clinical pharmacokinetics and metabolism: K. P. Maguire et al., Br. J. Clin. Pharmacol. 12, 405 (1981). HPLC determn in plasma: P. J. Taylor et al., J. Chromatogr. 581, 152 (1992). Review of clinical experience in depression: S. Donovan et al., Prog. Neuro-Psychopharmacol. Biol. Psychiatry 18, 1143-1162 (1994).
Properties: bp0.05 171-172°. mp 55-57°.
Melting point: mp 55-57°
Boiling point: bp0.05 171-172°
 
Derivative Type: Hydrochloride
CAS Registry Number: 897-15-4
Trademarks: Prothiaden (Knoll)
Molecular Formula: C19H21NS.HCl
Molecular Weight: 331.90
Percent Composition: C 68.76%, H 6.68%, N 4.22%, S 9.66%, Cl 10.68%
Properties: Crystals from ethanol-ether, mp 218-221°. uv max (methanol): 232, 260, 309 nm (log e 4.41, 3.97, 3.53).
Melting point: mp 218-221°
Absorption maximum: uv max (methanol): 232, 260, 309 nm (log e 4.41, 3.97, 3.53)
 
Therap-Cat: Antidepressant.
Keywords: Antidepressant; Tricyclics.