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CAS No 114977-28-5 , Docetaxel

  • Name: Docetaxel
  • Synonyms: Docetaxel;Taxotere; Trihydrate; 114977-28-5; CHEBI:4672; Docetaxel; Taxotere (TN); EmDOC; Taxotere(R); Docetaxel anhydrous;
  • CAS Registry Number:
  • Transport: 1544
  • Melting Point: 232 ºC
  • Density: 1.37 g/cm3
  • Refractive index: 1.618
  • Alpha: -36 º (C=0.74,ETOH)
  • Safety Statements: 26-36/37
  • Hazard Symbols: Xi: Irritant;
  • Molecular Weight: 807.87922
  • InchiKey: ZDZOTLJHXYCWBA-VCVYQWHSSA-N
  • InChI: InChI=1S/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38
    (52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,
    34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,
    26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52)/t26-,27-,28+,30-,31+,
    32+,33-,35-,41+,42-,43+/m0/s1
  • Risk Statements: 36/37/38
  • Molecular Formula: C43H53NO14
  • Molecular Structure:CAS No:114977-28-5 Docetaxel
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114977-28-5 Docetaxel

  • Docetaxel, 98%
  • China Suzhou Rovathin Foreign Trade Co.,Ltd [Manufacturer]
  • Tel: 86-512-65816829/ 86-512-61978430
  • Fax: 86-512-65816839
  • Address: Suzhou Rovathin Foreign Trade Co.,Ltd
    (Sales Company of Affiliated Plant in China)
    Room 603, 327 of ShiZi Street,
    Suzhou, Jiangsu, China 215006 ,China
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114977-28-5 DOCETAXEL

  • DOCETAXEL, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,China
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114977-28-5 DOCETAXEL

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114977-28-5 Taxotere

  • China YiPeng Chemical [Manufacturers]
  • Tel: 571 85376369
  • Fax: 571 88233092
  • Address: Building 4,High-tech Industrial Park,No. 588 Feijiatang Road,Xiacheng District, Hangzhou, China ,ZheJiangChina
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114977-28-5 DOCETAXEL

  • China HANGZHOU THINK CHEMICAL CO. [Manufacturer]
  • Tel: +86-571-81956191/ +86-571-81956192
  • Fax: +86-571-81956190
  • Address: 425 MOGAN HILL ROAD ,
    HANGZHOU, 310011 CHINA ,China
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114977-28-5 Docetaxel

  • China Goly Chemical Co., Ltd. [Manufacturers]
  • Tel: +86-(632)-6163187
  • Fax: +86-(632)-5100028
  • Address: Room No.6.Building21 LongXingBeiLi,ShiZhong, ZaoZhua, ShanDong 277102, ZaoZhuang,ShanDongChina
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114977-28-5 Docetaxel

  • Docetaxel
  • United States RIA International [Manufacturer]
  • Tel: 19735811282
  • Fax: 19735811283
  • Address: 11 Melanie Lane #17 East Hanover 07936 NJ UNITED STATES NJ,United States
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114977-28-5 Docetaxel Anhydrous

  • Docetaxel Anhydrous, 99%min
  • China Shanghai Everchem Co.,Ltd. [Manufacturer]
  • Tel: +86-21-5192-3949
  • Fax: +86-21-5192-3940
  • Address: No.277 Zheqiao Road,
    Shanghai 201206 China ,China
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114977-28-5 DOCETAXEL

  • China Xingcheng Chempharm Co., Ltd [Manufacturer]
  • Tel: +86-576-88525005/ +86-576-88886292
  • Fax: +86-576-88225056
  • Address: B Area, 10F, Yaoda Mansion, 289, Shifu Road, Taizhou, Zhejiang, China 318000 ,China
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114977-28-5 DOCETAXEL

  • Canada TLC PharmaChem., Inc. [Manufacturer]
  • Tel: 905-760-1098
  • Fax: 905-760-2098
  • Address: TLC PharmaChem., Inc.
    5-150 Connie Crescent
    Concord, Ontario
    L4K 1L9, Canada ,Canada
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References of Docetaxel
Title: Docetaxel
CAS Registry Number: 114977-28-5
CAS Name: (aR,bS)-b-[[(1,1-Dimethylethoxy)carbonyl]amino]-a-hydroxybenzenepropanoic acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester
Synonyms: N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol
Manufacturers' Codes: NSC-628503; RP-56976
Trademarks: Taxotere (Aventis)
Molecular Formula: C43H53NO14
Molecular Weight: 807.88
Percent Composition: C 63.93%, H 6.61%, N 1.73%, O 27.73%
Literature References: Semisynthetic derivative of paclitaxel, q.v., prepd using a natural precursor, 10-deacetylbaccatin III, extracted from the needles of the European yew tree, Taxus baccata L., Taxaceae. Antimitotic agent that promotes the assembly of microtubules and inhibits their depolymerization to free tubulin. Prepn: M. Colin et al., EP 253738; eidem, US 4814470 (1988, 1989 both to Rh?ne-Poulenc Sante); L. Mangatal et al., Tetrahedron 45, 4177 (1989). Synthesis of the side chain: J.-N. Denis et al., J. Org. Chem. 56, 6939 (1991). Structure-activity study: F. Guéritte-Voegelein et al., J. Med. Chem. 34, 992 (1991). Cytotoxic activity and mechanism of action: I. Ringel, S. B. Horwitz, J. Natl. Cancer Inst. 83, 288 (1991). In vivo antitumor activity: M.-C. Bissery et al., Cancer Res. 51, 4845 (1991). HPLC determn: J. C. Vergniol et al., J. Chromatogr. 582, 273 (1992). Clinical pharmacokinetics and toxicology: J.-M. Extra et al., Cancer Res. 53, 1037 (1993). Clinical trials in prostate cancer: I. F. Tannock et al., N. Engl. J. Med. 351, 1502 (2004); D. P. Petrylak et al., ibid. 1513. Symposium on clinical experience: Semin. Oncol. 27, Suppl. 3, 1-29 (2000). Review of mechanism of action and combination therapies: R. S. Herbst, F. R. Khuri, Cancer Treat. Rev. 29, 407-415 (2003); of clinical studies in non-small cell lung cancer: A. M. Davies et al., Expert Opin. Pharmacother. 4, 553-565 (2003).
Properties: mp 232°. [a]D -36° (c = 0.74 in ethanol). uv max: 230, 275, 283 nm (e 14800, 1730, 1670).
Melting point: mp 232°
Optical Rotation: [a]D -36° (c = 0.74 in ethanol)
Absorption maximum: uv max: 230, 275, 283 nm (e 14800, 1730, 1670)
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Alkaloids/Natural Products; Taxanes.