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CAS No 114977-28-5 , Docetaxel

  • Name: Docetaxel
  • Synonyms: Docetaxel;Taxotere; Trihydrate; 114977-28-5; CHEBI:4672; Docetaxel; Taxotere (TN); EmDOC; Taxotere(R); Docetaxel anhydrous;
  • CAS Registry Number:
  • Transport: 1544
  • Melting Point: 232 ºC
  • Density: 1.37 g/cm3
  • Refractive index: 1.618
  • Alpha: -36 º (C=0.74,ETOH)
  • Safety Statements: 26-36/37
  • Hazard Symbols: Xi: Irritant;
  • Molecular Weight: 807.87922
  • InchiKey: ZDZOTLJHXYCWBA-VCVYQWHSSA-N
  • InChI: InChI=1S/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38
    (52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,
    34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,
    26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52)/t26-,27-,28+,30-,31+,
    32+,33-,35-,41+,42-,43+/m0/s1
  • Risk Statements: 36/37/38
  • Molecular Formula: C43H53NO14
  • Molecular Structure:CAS No:114977-28-5 Docetaxel
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114977-28-5 Docetaxel

  • Product Name: Docetaxel Synonyms: TAXOTERE;n-debenzoyl-n-tert-butoxycarbonyl-10-deacetyl taxol;)benz(1,2-b)oxet-9-ylester,(2ar-(2a-alpha,4-beta,4a-beta,6-beta,9-alpha(alph;-,12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydr;...
  • Min. Order: 1
  • FOB Price: USDfalse - false /
  • China Tocopharm Co., Ltd. [Manufacturer]
  • Tel: 86-021-31608287
  • Address: RM506,No.80 Yichuan Rd., Shanghai,ShanghaiChina
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114977-28-5 Docetaxel (Taxotere)

  • Docetaxel (Taxotere) can inhibit microtubule disassembly with IC50 of a range of 0.31-100 nM. More information please visit the website: http://www.creative-enzymes.com/product/Docetaxel-Taxotere-_2231.html
  • Min. Order: 10
  • United States Creative Enzymes [Manufacturer]
  • Tel: 1-516-6698109
  • Fax: 1-631-9388127
  • Address: 45-1 Ramsey Road, Shirley New York,New YorkUnited States
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114977-28-5 Docetaxel

  • Name Docetaxel n-debenzoyl-n-tert-butoxycarbonyl-10-deacetyl taxol Cas No. 114977-28-5 Formula C43H53NO14 MW807.88
  • China Taizhou Bolon Pharmchem CO.,Ltd [Manufacturer]
  • Tel: 86-576-88702853
  • Address: Huangyan Jiangkou taizhou,ZhejiangChina
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114977-28-5 Anti-Cancer Powder Docetaxel 99% CAS 114977-28-5

  • Product Name: Docetaxel Synonyms: docetaxel; N-debenzoyl-N-tert-butoxycarbonyl-10-deacetyl taxol; Docetaxel Anhydrous; (2alpha,5beta,7beta,10beta,13alpha)-4-(acetyloxy)-13-({(3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7,10-...
  • Min. Order: 0.001
  • FOB Price: USDfalse - false /
  • China Shenzhen Simeiquan Biotechnology Co., Ltd. [Manufacturer]
  • Tel: 86-180-38176803
  • Fax: 86-180-38176803
  • Address: #2 New Area Road, Minzhi Street, Longhua New District, Shenzhen, Guangdong,?China Shenzhen,GuangdongChina
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114977-28-5 white crystalline Docetaxel

  • White to off white crystalline Docetaxel for the treatment of breast and non-small cell lung cancer. Skyp : Hormonepowder chen winnie@chembj.com Keywords Docetaxel benzenepropanoicacid,beta-(((1,1-dimethylethoxy)carbonyl)amino)-alpha-hydroxy;beta-s*)...
  • China Shenzhen Simeiquan Biotechnology Co., Ltd. [Manufacturer]
  • Tel: 86-27-50756083
  • Address: New Area Road, Minzhi Street, Longhua New Area, Shenzhen shenzhen,GuangdongChina
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114977-28-5 Docetaxel

  • Docetaxel English Synonyms: TAXOTERE;n-debenzoyl-n-tert-butoxycarbonyl-10-deacetyl taxol;)benz(1,2-b)oxet-9-ylester,(2ar-(2a-alpha,4-beta,4a-beta,6-beta,9-alpha(alph;-,12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydr;benzen...
  • Min. Order: 100
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  • China Hubei Yuancheng Chemical Co.,Ltd [Manufacturer]
  • Tel: 86-27-68886667
  • Fax: 86-27-88048077
  • Address: NO866, Ziyang Road Wuhan,HubeiChina
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114977-28-5 Docetaxel

  • Docetaxel
  • Germany chemcube UG [Manufacturer]
  • Tel: +49 (22 08) 7 75 04 06
  • Fax: +49 (22 08) 7 75 02 30 /
    +49 (32 12) 1 00 74 76
  • Address: chemcube UG
    Salierweg 1
    53859 Niederkassel
    Germany ,Germany
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114977-28-5 DOCETAXEL

  • Germany Cfm Oskar Tropitzsch [Manufacturer]
  • Tel: +49-9231-9619-0
  • Fax: +49-9231-9619-60
  • Address: Cfm Oskar Tropitzsch
    Waldershofer Str. 49-51
    95615 Marktredwitz
    Germany ,Germany
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114977-28-5 Taxotere

  • China Xilin Chemical Group Co., Ltd []
  • Tel: +86-(0)-15527136576
  • Fax: +86-(27)-83820093
  • Address: 16# Luojiashan, Wuchang District, Wuhan, Hubei 430071, ,China
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114977-28-5 Taxotere

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References of Docetaxel
Title: Docetaxel
CAS Registry Number: 114977-28-5
CAS Name: (aR,bS)-b-[[(1,1-Dimethylethoxy)carbonyl]amino]-a-hydroxybenzenepropanoic acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester
Synonyms: N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol
Manufacturers' Codes: NSC-628503; RP-56976
Trademarks: Taxotere (Aventis)
Molecular Formula: C43H53NO14
Molecular Weight: 807.88
Percent Composition: C 63.93%, H 6.61%, N 1.73%, O 27.73%
Literature References: Semisynthetic derivative of paclitaxel, q.v., prepd using a natural precursor, 10-deacetylbaccatin III, extracted from the needles of the European yew tree, Taxus baccata L., Taxaceae. Antimitotic agent that promotes the assembly of microtubules and inhibits their depolymerization to free tubulin. Prepn: M. Colin et al., EP 253738; eidem, US 4814470 (1988, 1989 both to Rh?ne-Poulenc Sante); L. Mangatal et al., Tetrahedron 45, 4177 (1989). Synthesis of the side chain: J.-N. Denis et al., J. Org. Chem. 56, 6939 (1991). Structure-activity study: F. Guéritte-Voegelein et al., J. Med. Chem. 34, 992 (1991). Cytotoxic activity and mechanism of action: I. Ringel, S. B. Horwitz, J. Natl. Cancer Inst. 83, 288 (1991). In vivo antitumor activity: M.-C. Bissery et al., Cancer Res. 51, 4845 (1991). HPLC determn: J. C. Vergniol et al., J. Chromatogr. 582, 273 (1992). Clinical pharmacokinetics and toxicology: J.-M. Extra et al., Cancer Res. 53, 1037 (1993). Clinical trials in prostate cancer: I. F. Tannock et al., N. Engl. J. Med. 351, 1502 (2004); D. P. Petrylak et al., ibid. 1513. Symposium on clinical experience: Semin. Oncol. 27, Suppl. 3, 1-29 (2000). Review of mechanism of action and combination therapies: R. S. Herbst, F. R. Khuri, Cancer Treat. Rev. 29, 407-415 (2003); of clinical studies in non-small cell lung cancer: A. M. Davies et al., Expert Opin. Pharmacother. 4, 553-565 (2003).
Properties: mp 232°. [a]D -36° (c = 0.74 in ethanol). uv max: 230, 275, 283 nm (e 14800, 1730, 1670).
Melting point: mp 232°
Optical Rotation: [a]D -36° (c = 0.74 in ethanol)
Absorption maximum: uv max: 230, 275, 283 nm (e 14800, 1730, 1670)
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Alkaloids/Natural Products; Taxanes.