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CAS No 115956-12-2 , Dolasteron

  • Name: Dolasteron
  • Synonyms: (2alpha,6alpha,8alpha,9abeta)-Octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl-1H-indole-3-carboxylate;Dolasteron;
  • CAS Registry Number:
  • Melting Point: 278 ºC
  • Density: 1.37 g/cm3
  • Refractive index: 1.76
  • Molecular Weight: 324.37
  • InChI: InChI=1/C19H20N2O3/c22-17-10-21-13-5-12(17)6-14(21)8-15(7-13)24-19(23)18-16-4-2-1-3-11(16)9-20-18/h1-4,12-15H,5-10H2
  • Molecular Formula: C19H20N2O3
  • Molecular Structure:CAS No:115956-12-2 Dolasteron
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115956-12-2 1H-Indole-3-carboxylicacid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, stereoisomer

  • China Syntechem Co.,Ltd [Manufacturer]
  • Tel: +86-519-89882658
  • Fax: +86-519-8512 5369
  • Address: Syntechem Co.,Ltd
    18 South Zhulin Rd.
    Tianning district,Changzhou
    Jiangsu China 213022 ,China
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115956-12-2 LTS00548 DOLASETRON

  • Hong kong Lotus chemical (HK) Limited [Manufacturer]
  • Tel: +86 23 86092822 (China)/ +852 29738324 (Hong Kong)
  • Fax: +86 23 86092822
  • Address: Lotus Chemical Limited,. (China office)
    Address: 602 Room, 172#, Gaoyan Road, Yubei District, Chongqing, China
    Postcode: 401120 ,Hong kong
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115956-12-2 DOLASETRON

  • United States Kingchem LLC [Manufacturer]
  • Tel: 201-825-9988
  • Fax: 201-825-9148
  • Address: Kingchem LLC
    5 Pearl Ct
    Allendale Park
    Allendale, NJ 07401 ,United States
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115956-12-2 Dolasteron

  • Dolasteron
  • China Sunkingchem Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-28-88007744
  • Fax: +86-28-85193812
  • Address: A-703, Gaofa Building, Jiuxing Road 6#, Hi-Tech Zone 610041, Chengdu, Sichuan, China.610041 ChengduCHINA Chengdu,China
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115956-12-2 Dolasteron

  • Dolasteron dolasetron (2a,6a,8a,9ab)-Hexahydro-8-Hydroxy-2,6-Methano-2h-Quinolizin-3(4h)-One Endo-hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3-(4H)-one Endo-hexahydro-hydroxy-2,6-methano-2H-quinolizin-3-(4H)-one (2a,6a,8a,9ab)-Hexahydro-8-hydroxy-...
  • China Zeniview Chemistry Technology Co., Ltd. [Manufacturer]
  • Tel: +86-25-86088590
  • Fax: +86-25-85612276
  • Address: No.05,No.01 Hangzhongmen Dajie, Nanjing, China 210016 Nanjing CHINA 210016 NanjingCHINA Nanjing,China
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115956-12-2 Dolasetron

  • Dolasetron, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,China
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115956-12-2 (2alpha,6alpha,8alpha,9alpha,beta)-Hexahydro-8-hydroxy-2,6-methano-2H-quinolizine-3(4H)-one

  • (2alpha,6alpha,8alpha,9alpha,beta)-Hexahydro-8-hydroxy-2,6-methano-2H-quinolizine-3(4H)-one, 99%
  • China henglidahuagong co,.Ltd [Manufacturer]
  • Tel: 13996793719
  • Fax: 86+(0535?2260023
  • Address: NO 238,CANAN ROAD NORTH OF WENCANG,LAIZHOU CITY,SHANGDONG,CHINA LAIZHOU CITYCHINA LAIZHOU CITY,China
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115956-12-2 Dolasetron

  • Dolasetron, 99%UP
  • China Facus Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-(0)574-62378411
  • Fax: +86-(0)574-62378410
  • Address: 24Fl,Yuanjing Building,Beilun District, Zhejiang 315800 NingboCHINA Ningbo,China
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115956-12-2 dolasteron

  • dolasteron
  • China sales@credimate.com [Manufacturer]
  • Tel: +86 21 51872179
  • Fax: +86 21 51872179
  • Address: Room 2110, Tower 1, Changan Mansion, No. 1001 Changan Road200070 ShanghaiCHINA Shanghai,China
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115956-12-2 DOLASETRON

  • Canada Synth?se AptoChem Inc. [Manufacturer]
  • Tel: 514-496-4252
  • Fax: 514-496-4253
  • Address: Synth?se AptoChem Inc.
    6100 Royalmount Ave
    Montreal, QC
    Canada
    H4P 2R2 ,Canada
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References of Dolasteron
Title: Dolasetron
CAS Registry Number: 115956-12-2
CAS Name: 1H-Indole-3-carboxylic acid (2a,6a,8a,9ab)-octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester
Synonyms: endo-hexahydro-8-(3-indolylcarbonyloxy)-2,6-methano-2H-quinolizin-3(4H)-one
Manufacturers' Codes: MDL-73147
Molecular Formula: C19H20N2O3
Molecular Weight: 324.37
Percent Composition: C 70.35%, H 6.21%, N 8.64%, O 14.80%
Literature References: Bridged pseudopelletierine derivative; specific serotonin (5HT3) receptor antagonist. Prepn: M. W. Gittos, EP 266730; idem et al., US 4906755 (1988, 1990 both to Merrell Dow). Binding study: P. H. Boeijinga et al., Eur. J. Pharmacol. 219, 9 (1992). Pharmacology: R. C. Miller et al., Drug Dev. Res. 28, 87 (1993). Clinical pharmacokinetics: H. Boxenbaum et al., Biopharm. Drug Dispos. 13, 693 (1992); eidem, ibid. 14, 131 (1993). GC-MS and LC determn in plasma: T. A. Gillespie et al., J. Pharm. Biomed. Anal. 11, 955 (1993). Clinical trial in emetogenic chemotherapy: A. A. Fauser et al., Eur. J. Cancer 32A, 1523 (1996); for prevention of postoperative nausea: S. G. Graczyk et al., Anesth. Analg. 84, 325 (1997).
 
Derivative Type: Methanesulfonate
CAS Registry Number: 115956-13-3
Synonyms: Dolasetron mesylate
Manufacturers' Codes: MDL-73147EF
Trademarks: Anzemet (Aventis)
Molecular Formula: C19H20N2O3.CH3SO3H
Molecular Weight: 420.48
Percent Composition: C 57.13%, H 5.75%, N 6.66%, O 22.83%, S 7.63%
Properties: Crystalline solid, mp 278°.
Melting point: mp 278°
 
Therap-Cat: Antiemetic.
Keywords: Antiemetic; Antimigraine; Serotonin Receptor Antagonist.