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CAS No 117399-94-7 , Endothelin 1

  • Name: Endothelin 1
  • Synonyms: 45187_FLUKA;Endothelin I; 123626-67-5; 117399-94-7; E7764_SIGMA;Endothelin 1;
  • CAS Registry Number:
  • Safety Statements:
    WGK Germany 3
    RTECS KE9446500
    F 3-10
  • Molecular Weight: 2491.90206
  • InchiKey: ZUBDGKVDJUIMQQ-ZTNLKOGPSA-N
  • InChI: InChI=1S/C109H159N25O32S5/c1-12-56(9)87(107(163)125-76(109(165)166)39-
    60-43-113-65-24-18-17-23-63(60)65)134-108(164)88(57(10)13-2)133-99(155)
    75(42-85(143)144)123-94(150)70(36-54(5)6)118-97(153)73(40-61-44-112-52-
    114-61)121-103(159)80-49-169-168-48-64(111)89(145)126-77(45-135)102(158)
    131-81-50-170-171-51-82(105(161)132-86(55(7)8)106(162)124-72(38-59-26-
    28-62(138)29-27-59)95(151)120-71(96(152)130-80)37-58-21-15-14-16-22-58)
    129-91(147)67(30-31-83(139)140)116-90(146)66(25-19-20-33-110)115-98(154)
    74(41-84(141)142)122-92(148)68(32-34-167-11)117-93(149)69(35-53(3)4)119-
    100(156)78(46-136)127-101(157)79(47-137)128-104(81)160/h14-18,21-24,
    26-29,43-44,52-57,64,66-82,86-88,113,135-138H,12-13,19-20,25,30-42,
    45-51,110-111H2,1-11H3,(H,112,114)(H,115,154)(H,116,146)(H,117,149)(H,
    118,153)(H,119,156)(H,120,151)(H,121,159)(H,122,148)(H,123,150)(H,124,
    162)(H,125,163)(H,126,145)(H,127,157)(H,128,160)(H,129,147)(H,130,
    152)(H,131,158)(H,132,161)(H,133,155)(H,134,164)(H,139,140)(H,141,
    142)(H,143,144)(H,165,166)/t56-,57-,64-,66-,67-,68-,69-,70-,71-,72-,73-,
    74-,75-,76-,77-,78-,79-,80-,81-,82-,86-,87-,88-/m0/s1
  • Molecular Formula: C109H159N25O32S5
  • Molecular Structure:CAS No:117399-94-7 Endothelin 1

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  • Endothelin-1, a 21-amino acid peptide from vascular endothelial cells of different mammalian species, is one of the most potent vasoconstrictors. ET-1 exerts a wide variety of effects on both vascular and non-vascular (e.g. heart, lung, brain) tissue...
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117399-94-7 endothelin 1

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117399-94-7 Endothelin 1 (human, porcine)

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117399-94-7 ENDOTHELIN-1 (HUMAN, PORCINE)

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  • China Xilin Chemical Group Co., Ltd null
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117399-94-7 IN-1, HUMAN

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References of Endothelin 1
Title: Endothelin
CAS Registry Number: 117399-94-7
Synonyms: Endothelin-1; ET-1
Literature References: Potent vasoconstrictor peptide produced by mammalian vascular endothelial cells; present in low concentrations in normal serum. Composed of 21 amino acid residues; mol wt ~2500 Da. Isoln, characterization and cloning of porcine endothelin: M. Yanagisawa et al., Nature 332, 411 (1988). Structural identity of porcine and human endothelin: Y. Itoh et al., FEBS Lett. 231, 440 (1988). Structural similarity with the snake venom toxins, sarafotoxins S6: C. Y. Lee, V. A. Chiappinelli, Nature 335, 303 (1988); C. Takasaki et al., ibid. 303. Identification in serum by radioimmunoassay: K. Ando et al., FEBS Lett. 245, 164 (1989). Two additional isoforms, known as endothelin-2 and endothelin-3, have been identified. Structures and comparative pharmacology of human endothelin isopeptides: A. Inoue et al., Proc. Natl. Acad. Sci. USA 86, 2863 (1989). Mechanism of action study: Y. Hirata et al., Biochem. Biophys. Res. Commun. 154, 868 (1988). Possible role in acute renal failure: J. D. Firth et al., Lancet 2, 1179 (1988). In vivo effects on pulmonary and systemic hemodynamics: H. L. Lippton et al., J. Appl. Physiol. 66, 1008 (1989). Review: T. Masaki, J. Cardiovasc. Pharmacol. 13, Suppl. 5, S1-S4 (1989).